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Immunotheranostic microbubbles (iMBs) - a modular platform for dendritic cell vaccine delivery applied to breast cancer immunotherapy
BackgroundTherapeutic strategies engaging the immune system against malignant cells have revolutionized the field of oncology. Proficiency of...
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Advanced Vesicular Systems for Antifungal Drug Delivery
Fungal infections are considered one of the most serious conditions as their occurrence has increased lately. Fungi like Candida , Fusarium , and Aspergillus...
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Glucosylated nanoparticles for the oral delivery of antibiotics to the proximal small intestine protect mice from gut dysbiosis
Orally delivered antibiotics can reach the caecum and colon, and induce gut dysbiosis. Here we show that the encapsulation of antibiotics in orally...
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Exploring ITM2A as a new potential target for brain delivery
BackgroundIntegral membrane protein 2A (ITM2A) is a transmembrane protein expressed in a variety of tissues; little is known about its function,...
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Targeting the Inside of Cells with Biologicals: Chemicals as a Delivery Strategy
Delivering macromolecules into the cytosol or nucleus is possible in vitro for DNA, RNA and proteins, but translation for clinical use has been...
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Physiologically Based Pharmacokinetic Model of Brain Delivery of Plasma Protein Bound Drugs
IntroductionA physiologically based pharmacokinetic (PBPK) model is developed that focuses on the kinetic parameters of drug association and...
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Nanoscale, antigen encounter-dependent, IL-12 delivery by CAR T cells plus PD-L1 blockade for cancer treatment
BackgroundChimeric antigen receptor (CAR)-T cell therapies for the treatment of hematological malignancies experienced tremendous progress in the...
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Solid Lipid Nanoparticles-Based Drug and Gene Delivery to Macrophages
The current chapter discusses targeting macrophages with solid lipid nanoparticles (SLNs) loaded with drugs and genetic material. Macrophages are the...
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Thin film hydration versus modified spraying technique to fabricate intranasal spanlastic nanovesicles for rasagiline mesylate brain delivery: Characterization, statistical optimization, and in vivo pharmacokinetic evaluation
Rasagiline mesylate (RM) is a monoamine oxidase inhibitor that is commonly used to alleviate the symptoms of Parkinson’s disease. However, it suffers...
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Recent Synergy of Nanodiamonds: Role in Brain-Targeted Drug Delivery for the Management of Neurological Disorders
The aim of the present review article is to summarize the role of nanodiamonds in various neurological diseases. We have taken related literature of...
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Nanocarriers in Transdermal Drug Delivery
The transdermal route of drug administration is the most widely used route for systemic administration of drugs due to the convenience and...
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One Platform Comparison of Polymeric and Lipidic Nanoparticles for the Delivery of Amphotericin B
Amphotericin B (AmB) is a membrane-acting antibiotic used for the treatment of fungal and protozoal infections. AmB exists in various molecular...
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Marine Collagen: Promising Biomaterial in Delivery of Therapeutics for Cancer Therapy
Collagens are high-molecular-weight complex dominant proteins present in all living organisms. Various organisms have been exploited to extract...
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Exosomes as Carriers for Drug Delivery in Cancer Therapy
Exosomes are extracellular vesicles secreted by cells with a particle size of 30–150 nm in diameter. Exosomes can be used as natural drug carriers....
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Ethosomes as Nanocarriers for the Development of Skin Delivery Formulations
The use of nanotechnology has been extensively explored for develo** efficient drug delivery systems towards topical and transdermal applications....
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Endosomal Escape of Bioactives Deployed via Nanocarriers: Insights Into the Design of Polymeric Micelles
Cytoplasmic delivery of bioactives requires the use of strategies such as active transport, electroporation, or the use of nanocarriers such as...
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MTX-PEG-modified CG/DMMA polymeric micelles for targeted delivery of doxorubicin to induce synergistic autophagic death against triple-negative breast cancer
The chemotherapy of triple-negative breast cancer based on doxorubicin (DOX) regimens suffers from great challenges on toxicity and autophagy raised...
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Systemic Delivery of a Monoclonal Antibody to Immunologically Block Myostatin in the A17 Mouse Model of OPMD
Oculopharyngeal muscular dystrophy (OPMD) is a late-onset rare muscle disease affecting approximately 1 in 80,000 individuals worldwide. However, it...
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In vivo evaluation of biodistribution and toxicity of pH-responsive strontium nanoparticles for gene delivery
PurposeLow efficacy of parenteral administration of naked therapeutic genes is associated with the presence of biological barriers including...
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Recent Advancement in Nanotechnology-Based Drug Delivery System Against Viral Infections
In the last few decades, the exponential rise in the incidence of viral infections sets a global health emergency across the world. The biomimetic...
