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Cell survival after DNA damage in the comet assay
The comet assay is widely used in basic research, genotoxicity testing, and human biomonitoring. However, interpretation of the comet assay data...
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Developmental Neurotoxicity of Fipronil and Rotenone on a Human Neuronal In Vitro Test System
Pesticide exposure during in utero and early postnatal development can cause a wide range of neurological defects. However, relatively few...
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LINE-1 Methylation Index Correlates with Sister Chromatid Exchanges and Chromatid but Not Chromosome Aberrations in Personnel from a Nuclear Chemical Facility with Incorporated Plutonium-239
AbstractThe level of chromosomal abnormalities in the somatic cells of adult individuals is characterized by significant interindividual variability,...
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Understanding the Heterogeneity in Mast Cell Role in Host Defence During Leishmaniasis
Mast cells (MCs) are involved in clearing invading pathogens at the skin surface and play an important role in innate and adaptive defences. Their...
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Albumin-Embellished Arsenic Trioxide-Loaded Polymeric Nanoparticles Enhance Tumor Accumulation and Anticancer Efficacy via Transcytosis for Hepatocellular Carcinoma Therapy
Arsenic trioxide (ATO) has efficient anticancer effect on hepatocellular carcinoma (HCC) in clinical trials, but its off-target distribution and side...
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Kallikrein 8-Dependent and Independent Synaptic Tagging and Modulation of Long-Term Potentiation: A Quest for the Associated Signaling Pathway(s)
Synaptic tagging is a plausible hypothesis to explain relational memory. However, why and how the tagged synapses can be distinguished from other...
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Determining the toxicological effects of indoor air pollution on both a healthy and an inflammatory-comprised model of the alveolar epithelial barrier in vitro
Exposure to indoor air pollutants (IAP) has increased recently, with people spending more time indoors ( i.e. homes, offices, schools and...
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γδ T cells suppress Plasmodium falciparum blood-stage infection by direct killing and phagocytosis
Activated Vγ9Vδ2 (γδ2) T lymphocytes that sense parasite-produced phosphoantigens are expanded in Plasmodium falciparum– infected patients. Although...
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Endosomes and Microtubles are Required for Productive Infection in Aquareovirus
Grass carp reovirus (GCRV), the genus Aquareovirus in family Reoviridae , is viewed as the most pathogenic aquareovirus. To understand the molecular...
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Measuring Adaptive Responses Following Chronic and Low Dose Exposure in Amphibians
Adaptive responses can be used as biological indicators of chronic low dose exposure to ionizing radiation. The micronucleus assay has been used to...
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Mitochondrial transfer in tunneling nanotubes—a new target for cancer therapy
A century ago, the Warburg effect was first proposed, revealing that cancer cells predominantly rely on glycolysis during the process of...
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BMS794833 inhibits macrophage efferocytosis by directly binding to MERTK and inhibiting its activity
Myeloid epithelial reproductive proto-oncogene tyrosine kinase (MERTK) plays an essential role in modulating cancer immune tolerance by regulating...
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MMP3 activity rather than cortical stiffness determines NHE1-dependent invasiveness of melanoma cells
BackgroundBoth cell adhesion and matrix metalloproteinase (MMP) activity depend on pH at the cell surface. By regulating extracellular juxtamembrane...
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Synthetic Migrastatic: A New Class of Anticancer Drug
Cancer remains one of the fatal diseases in the last century. The mortality rate of different types of cancer is mainly related to metastasis, where...
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Inter-laboratory automation of the in vitro micronucleus assay using imaging flow cytometry and deep learning
The in vitro micronucleus assay is a globally significant method for DNA damage quantification used for regulatory compound safety testing in...
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Synthetic Migrastatic: A New Class of Anticancer Drug
Cancer remains one of the fatal diseases in the last century. The mortality rate of different types of cancer is mainly related to metastasis, where...
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Chemistry of Coleus forskohlii Briq.
Diterpenoid, forskolin is extracted from the roots of Coleus forskohlii Briq. (Syn. C. barbatus Benth. Lamiaceae). This species is the only source of...
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Indigo enhances wound healing activity of Caco-2 cells via activation of the aryl hydrocarbon receptor
Indigo Naturalis, also known as Qing Dai (QD) is a compound obtained from Indigofera tinctoria, Isatis tinctoria, and Polygonum tinctoria and is...
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Physiology
Effective invasion mechanism aids different worms of parasitic nature to set foot in their host body. Different identifying machineries indicate...