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Cynaropicrin disrupts tubulin and c-Myc-related signaling and induces parthanatos-type cell death in multiple myeloma
The majority of blood malignancies is incurable and has unforeseeable remitting-relapsing paths in response to different treatments. Cynaropicrin, a...
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Multi-omics identification of an immunogenic cell death-related signature for clear cell renal cell carcinoma in the context of 3P medicine and based on a 101-combination machine learning computational framework
BackgroundClear cell renal cell carcinoma (ccRCC) is a prevalent urological malignancy associated with a high mortality rate. The lack of a reliable...
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Cell Death Mechanisms in Cerebral Ischemia–Reperfusion Injury
Ischemic stroke is one of the major causes of morbidity and mortality, affecting millions of people worldwide. Inevitably, the interruption of...
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Induction of pyroptotic cell death as a potential tool for cancer treatment
Cancer is a complex pathological disease and the existing strategies for introducing chemotherapeutic agents have restricted potential due to a lack...
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Assessment of Neuronal Cell Death in Caenorhabditis elegans
The nematode Caenorhabditis elegans is a powerful experimental platform for cell biology studies. The molecular mechanisms that mediate cell death...
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Ferroptosis in tumors and its relationship to other programmed cell death: role of non-coding RNAs
Programmed cell death (PCD) plays an important role in many aspects of individual development, maintenance of body homeostasis and pathological...
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Anti-apoptotic Splicing Variant of AIMP2 Recover Mutant SOD1-Induced Neuronal Cell Death
Although a couple of studies have reported that mutant superoxide dismutase 1 (SOD1), one of the causative genes of familial amyotrophic lateral,...
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Cell death of Acanthamoeba castellanii following exposure to antimicrobial agents commonly included in contact lens disinfecting solutions
Several antimicrobial agents are commonly included in contact lens disinfectant solutions including chlorhexidine diacetate (CHX), polyhexamethylene...
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Cerebrolysin reduces excitotoxicity by modulation of cell-death proteins in delayed hours of ischemic reperfusion injury
Recent preclinical and clinical reports suggest that cerebrolysin shows neuroprotective properties similar to endogenous neurotrophic factors in...
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Death receptors 4/5 mediate tumour sensitivity to natural killer cell-mediated cytotoxicity in mismatch repair deficient colorectal cancer
BackgroundIdentifying the target of natural killer (NK) cells in colorectal cancer (CRC) is critical for optimising the clinical use of NK...
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Azaphilones produced by Penicillium maximae with their cell death-inducing activity on Adriamycin-treated cancer cell
BackgroundHeat shock proteins (Hsps) are overexpressed in several tumors and contribute to cell proliferation, metastasis, and anticancer drug...
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ROS-induced lipid peroxidation modulates cell death outcome: mechanisms behind apoptosis, autophagy, and ferroptosis
Reactive oxygen species (ROS) mediate lipid peroxidation and produce 4-hydroxynonenal and other related products, which play an important role in the...
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Biological roles of A-to-I editing: implications in innate immunity, cell death, and cancer immunotherapy
Adenosine-to-inosine (A-to-I) editing, a key RNA modification widely found in eukaryotes, is catalyzed by adenosine deaminases acting on RNA (ADARs)....
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Immunogenic cell stress and death
Dying mammalian cells emit numerous signals that interact with the host to dictate the immunological correlates of cellular stress and death. In the...
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Cell Death: a Molecular Perspective
One of the vital aspects of a cell is cell death to continue their normal cell turnover, propagation, proper development, and the maintenance of the...
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Mechanisms of cancer cell death induction by paclitaxel: an updated review
Chemoresistance of cancer cells is a major problem in treating cancer. Knowledge of how cancer cells may die or resist cancer drugs is critical to...
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The landscape of programmed cell death-related lncRNAs in Alzheimer’s disease and Parkinson’s disease
This study delivers a thorough analysis of long non-coding RNAs (lncRNAs) in regulating programmed cell death (PCD), vital for neurodegenerative...
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Piperlongumine and bortezomib synergically inhibit cholangiocarcinoma via ER stress–induced cell death
Cholangiocarcinoma (CCA) is a lethal malignancy of the cholangiocytes lining the biliary tree. Only 25% of affected patients are eligible for...
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Programmed cell death detection methods: a systematic review and a categorical comparison
Programmed cell death is considered a key player in a variety of cellular processes that helps to regulate tissue growth, embryogenesis, cell...
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Non-apoptotic Cell Death Control of Neutrophil Extracellular Trap Formation
Neutrophil extracellular traps (NETs) are networks of chromatin and microbicidal proteins released by neutrophils in response to infection and tissue...