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Grpel2 maintains cardiomyocyte survival in diabetic cardiomyopathy through DLST-mediated mitochondrial dysfunction: a proof-of-concept study
BackgroundDiabetic cardiomyopathy (DCM) has been considered as a major threat to health in individuals with diabetes. GrpE-like 2 (Grpel2), a...
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Comprehensive analysis of miRNA–mRNA regulatory network and potential drugs in chronic chagasic cardiomyopathy across human and mouse
BackgroundChronic chagasic cardiomyopathy (CCC) is the leading cause of heart failure in Latin America and often causes severe inflammation and...
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Systematic in vivo candidate evaluation uncovers therapeutic targets for LMNA dilated cardiomyopathy and risk of Lamin A toxicity
BackgroundDilated cardiomyopathy (DCM) is a severe, non-ischemic heart disease which ultimately results in heart failure (HF). Decades of research on...
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Reverse Takotsubo Cardiomyopathy Precipitated by Chronic Cocaine and Cannabis Use
This case report describes a 31-year-old man with 10 years of cocaine and cannabis dependence who developed reverse Takotsubo cardiomyopathy (rTC), a...
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Modular networks and genomic variation during progression from stable angina pectoris through ischemic cardiomyopathy to chronic heart failure
BackgroundAnalyzing disease–disease relationships plays an important role for understanding etiology, disease classification, and drug repositioning....
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Role of mitochondrial metabolic disorder and immune infiltration in diabetic cardiomyopathy: new insights from bioinformatics analysis
BackgroundDiabetic cardiomyopathy (DCM) is one of the common cardiovascular complications of diabetes and a leading cause of death in diabetic...
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Whole genome sequencing delineates regulatory, copy number, and cryptic splice variants in early onset cardiomyopathy
Cardiomyopathy (CMP) is a heritable disorder. Over 50% of cases are gene-elusive on clinical gene panel testing. The contribution of variants in...
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Patient-Specific Modelling and Parameter Optimisation to Simulate Dilated Cardiomyopathy in Children
PurposeLumped parameter modelling has been widely used to simulate cardiac function and physiological scenarios in cardiovascular research. Whereas...
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Identification and functional characterization of BICD2 as a candidate disease gene in an consanguineous family with dilated cardiomyopathy
BackgroundFamilial dilated cardiomyopathy (DCM) is a genetic cardiomyopathy that is associated with reduced left ventricle function or systolic...
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Circulating circRNA as biomarkers for dilated cardiomyopathy etiology
AbstractDilated cardiomyopathy (DCM) is the third most common cause of heart failure. The multidisciplinary nature of testing — involving genetics,...
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Toward a diagnostic CART model for Ischemic heart disease and idiopathic dilated cardiomyopathy based on heart rate total variability
Diagnosis of etiology in early-stage ischemic heart disease (IHD) and dilated cardiomyopathy (DCM) patients may be challenging. We aimed at...
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HTRA1-driven detachment of type I collagen from endoplasmic reticulum contributes to myocardial fibrosis in dilated cardiomyopathy
BackgroundThe aberrant secretion and excessive deposition of type I collagen (Col1) are important factors in the pathogenesis of myocardial fibrosis...
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On the Mechanism of Cardioprotective Effect of Fabomotizole in Alcoholic Cardiomyopathy
The molecular mechanisms underlying the cardioprotective effect of fabomotizole were studied using the translational rat model of alcoholic...
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A novel likely pathogenic variant in the FBXO32 gene associated with dilated cardiomyopathy according to whole‑exome sequencing
BackgroundFamilial dilated cardiomyopathy (DCM) is a genetic heart disorder characterized by progressive heart failure and sudden cardiac death. Over...
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The association between the clinical severity of heart failure and docosahexaenoic acid accumulation in hypertrophic cardiomyopathy
ObjectiveHypertrophic cardiomyopathy (HCM) is a common genetic disease with diverse morphology, symptoms, and prognosis. Hypertrophied myocardium...
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Extracellular matrix remodeling in animal models of anthracycline-induced cardiomyopathy: a meta-analysis
As in other cardiomyopathies, extracellular matrix (ECM) remodeling plays an important role in anthracycline-induced cardiomyopathy. To understand...
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I536T variant of RBM20 affects splicing of cardiac structural proteins that are causative for develo** dilated cardiomyopathy
AbstractRBM20 is one of the genes predisposing to dilated cardiomyopathy (DCM). Variants in the RS domain have been reported in many DCM patients,...
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A circular network of purine metabolism as coregulators of dilated cardiomyopathy
BackgroundThe crosstalk of purine biosynthesis and metabolism exists to balance the cell energy production, proliferation, survival and cytoplasmic...
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