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Velocity tracking of cardiac vector loops to identify signs of stress-induced ischaemia
Coronary artery disease (CAD) is among the leading causes of death worldwide. Initial studies require an electrocardiogram stress test often followed...
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Role of Ca2+ in healthy and pathologic cardiac function: from normal excitation–contraction coupling to mutations that cause inherited arrhythmia
Calcium (Ca 2+ ) ions are a key second messenger involved in the rhythmic excitation and contraction of cardiomyocytes throughout the heart. Proper...
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Effects of bepridil on early cardiac development of zebrafish
Bepridil is a commonly used medication for arrhythmia and heart failure. It primarily exerts hemodynamic effects by inhibiting Na + /K + movement and...
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Targeted Activation of HNF4α by AMPK Inhibits Apoptosis and Ameliorates Neurological Injury Caused by Cardiac Arrest in Rats
Previous studies have shown that AMPK plays an important role in cerebral ischemia–reperfusion injury by participating in apoptosis, but the exact...
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Drugs Used in Cardiac Arrhythmias
Cardiac arrhythmias range from the fast-beating tachyarrhythmias–which include atrial fibrillation, ventricular tachycardia, and fibrillation and the...
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The Neuroprotective Effects of Administration of Methylprednisolone in Cardiopulmonary Resuscitation in Experimental Cardiac Arrest Model
Although advances in diagnosis and treatment of cardiac arrest (CA) could improve neurological outcomes after cardiopulmonary resuscitation (CPR),...
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Rhythmic firing of neurons in the medulla of conscious freely behaving rats: rhythmic coupling with baroreceptor input
Recent investigations emphasized the importance of neural control of cardiovascular adjustments in complex behaviors, including stress, exercise,...
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Challenges and solutions to recruitment of neonates and children having cardiac surgery into a study using a novel sampling device
ObjectiveTo narratively describe the challenges and solutions required in delivering a non-commercial study of children undergoing cardiac surgery...
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Muscle metaboreflex activation during hypercapnia modifies nonlinear heart rhythm dynamics, increasing the complexity of the sinus node autonomic regulation in humans
Muscle metaboreflex activation during hypercapnia leads to enhanced pressive effects that are poorly understood while autonomic responses including...
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Gap Junctions and Cardiac Impulse Propagation. New Aspects of Arrhythmogenesis and Antiarrhythmic Agents Targeting Gap Junctions
A basic phenomenon of the heart is its regular beating and a directed propagation of the electrical impulse which, during the plateau phase of the...
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Cardiac Pacemaking Is an Emergent Property of Complex Synchronized Signaling on Multiple Scales
The generation of automaticity in the sinoatrial node is a multiscale process involving the integration of complex biochemical and biophysical...
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Effect of Direct and Mediated through Maternal Organism Activation of the Catecholaminergic System on Heart Rate Parameters in Rat Fetuses
We performed a comparative analysis of direct and mediated through the maternal organism effects of elevated catecholamine concentration on changes...
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Acute self-myofascial release modulates cardiac autonomic function and hemodynamic parameters at rest and reduces cardiovascular stress reaction
PurposeSelf-myofascial release (SMR) is a form of self-massage aiming to release tension, improve blood flow, and alleviate muscle soreness. This...
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How circadian variability of the heart rate and plasma electrolytes concentration influence the cardiac electrophysiology – model-based case study
The circadian rhythm of cardiac electrophysiology is dependent on many physiological and biochemical factors. Provided, that models describing the...
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Alda-1, an Activator of ALDH2, Improves Postresuscitation Cardiac and Neurological Outcomes by Inhibiting Pyroptosis in Swine
Aldehyde dehydrogenase 2 (ALDH2) has been proven to protect the heart and brain against regional ischemia/reperfusion injury, in which the protective...
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Insulin signaling is critical for sinoatrial node maintenance and function
Insulin and insulin-like growth factor 1 (IGF-1) signaling regulate cellular growth and glucose metabolism in the myocardium. However, their...
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Rapid Treatment with Intramuscular Magnesium Sulfate During Cardiopulmonary Resuscitation Does Not Provide Neuroprotection Following Cardiac Arrest
Brain injury is the most common cause of death for patients resuscitated from cardiac arrest. Magnesium is an attractive neuroprotective compound...
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PM2.5 Exposure Lowers Mitochondrial Endurance During Cardiac Recovery in a Rat Model of Myocardial Infarction
Many studies have reported the negative effect of PM 2.5 exposure on heart function which is likely to impair postcardiac surgery rehabilitation that...
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Is high sensitive-troponin I a reliable biomarker for cardiac injury in methadone toxicity? A prospective cross-sectional study
BackgroundMethadone is a synthetic opioid mostly used for detoxification therapy, as its use increases; the possibility for methadone-induced...
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The impact of damaging epilepsy and cardiac genetic variant burden in sudden death in the young
BackgroundSudden unexpected death in children is a tragic event. Understanding the genetics of sudden death in the young (SDY) enables family...
