Search
Search Results
-
Pharmacoproteomics of Brain Barrier Transporters and Substrate Design for the Brain Targeted Drug Delivery
One of the major reasons why central nervous system (CNS)-drug development has been challenging in the past, is the barriers that prevent substances...
-
Transgenic animal models to explore and modulate the blood brain and blood retinal barriers of the CNS
The unique environment of the brain and retina is tightly regulated by blood–brain barrier and the blood-retinal barrier, respectively, to ensure...
-
Brain Pathology in COVID-19: Clinical Manifestations and Potential Mechanisms
Neurological manifestations of coronavirus disease 2019 (COVID-19) are less noticeable than the respiratory symptoms, but they may be associated with...
-
The Role of Gut Microbiota in Blood–Brain Barrier Disruption after Stroke
Growing evidence has proved that alterations in the gut microbiota have been linked to neurological disorders including stroke. Structural and...
-
Anti-malaria drug artesunate prevents development of amyloid-β pathology in mice by upregulating PICALM at the blood-brain barrier
BackgroundPICALM is one of the most significant susceptibility factors for Alzheimer’s disease (AD). In humans and mice, PICALM is highly expressed...
-
Blood-Brain Barrier Function as a Biomarker in Toxicology: Impact of Environmental Toxicants
The blood-brain barrier (BBB) is a semipermeable endothelial barrier that plays a vital role in protecting and maintaining proper function of the...
-
Protective effect of resveratrol on mitochondrial biogenesis during hyperoxia-induced brain injury in neonatal pups
BackgroundNeonatal hyperoxic brain injury is caused by exposure to hyperphysiological oxygen content during the period of incomplete development of...
-
Psychological stress induces depressive-like behavior associated with bone marrow-derived monocyte infiltration into the hippocampus independent of blood–brain barrier disruption
BackgroundPsychological stress is one of the most important factors that trigger emotional disorders, such as depression and anxiety. Emerging...
-
Effects of Ischemic Stroke on Interstitial Fluid Clearance in Mouse Brain: a Bead Study
The clearance of brain interstitial fluid (ISF) is important in maintaining brain homeostasis. ISF clearance impairment leads to toxic material...
-
Brain Energy and Metabolism
All the processes described in this textbook require energy. Ample clinical evidence indicates that the brain is exquisitely sensitive to...
-
Bidirectional Communication Between the Brain and Other Organs: The Role of Extracellular Vesicles
A number of substances released by the brain under physiological and pathological conditions exert effects on other organs. In turn, substances...
-
One Train May Hide Another: Two Cases of Co-Occurring Primary Familial Brain Calcification and Alzheimer’s Disease
Primary familial brain calcification (PFBC) is a rare disorder that can manifest with a wide spectrum of motor, cognitive, and psychiatric symptoms...
-
Activation of aryl hydrocarbon receptor (AhR) in Alzheimer’s disease: role of tryptophan metabolites generated by gut host-microbiota
AbstractGut microbiota in interaction with intestinal host tissues influences many brain functions and microbial dysbiosis has been linked with brain...
-
Multifunctional nanomedicine strategies to manage brain diseases
Brain diseases represent a substantial social and economic burden, currently affecting one in six individuals worldwide. Brain research has been...
-
Application of Organ-on-Chip in Blood Brain Barrier Model
The blood–brain barrier (BBB) is one of the discerning endothelial barriers of the human body because of its selective permeability for the molecules...
-
Changes of blood-brain-barrier function and transfer of amyloid beta in rats with collagen-induced arthritis
BackgroundRheumatoid arthritis (RA) is characterized by synovial inflammation, cartilage damage, and systemic inflammation. RA is also associated...
-
Revolutionizing Stroke Care: Nanotechnology-Based Brain Delivery as a Novel Paradigm for Treatment and Diagnosis
Stroke, a severe medical condition arising from abnormalities in the coagulation-fibrinolysis cycle and metabolic processes, results in brain cell...
-
Recombinant annexin A2 inhibits peripheral leukocyte activation and brain infiltration after traumatic brain injury
BackgroundTraumatic brain injury (TBI) is a significant cause of death and disability worldwide. The TLR4-NFκB signaling cascade is the critical...
-
Mechanisms of Cerebral Angiogenesis in Health and Brain Pathology
This literature review assesses the characteristics of the cerebral microcirculatory system. The development and maturation of the microcirculation...
-
A new insight into the role of pericytes in ischemic stroke
The functional structure of the blood–brain barrier (BBB) deteriorates after stroke by develo** diffuse microvascular and neurovascular dysfunction...
