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DNA damage repair and cancer immunotherapy
Cells are exposed to multiple endogenous and exogenous stresses daily, some of which can induce DNA damage, a major source of genomic instability. To...
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PARP inhibitor and immune checkpoint inhibitor have synergism efficacy in gallbladder cancer
Gallbladder cancer (GBC) is an aggressive cancer with poor prognosis. PARP inhibitors (PARPi) target PARP enzymes and have shown efficacy in patients...
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Protein lipidation in cancer: mechanisms, dysregulation and emerging drug targets
Protein lipidation describes a diverse class of post-translational modifications (PTMs) that is regulated by over 40 enzymes, targeting more than...
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The oncogenic role of NF1 in gallbladder cancer through regulation of YAP1 stability by direct interaction with YAP1
BackgroundGallbladder cancer (GBC) is the most prevalent and invasive biliary tract malignancy. As a GTPase-activating protein, Neurofibromin 1 (NF1)...
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Is prior cancer history a hindrance for non-small cell lung cancer patients to participate in clinical trials?
BackgroundThis study aimed to explore the effect of a prior cancer history on the survivals of resected non-small cell lung cancer (NSCLC) patients.
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Efficacy and safety of FOLFIRINOX as salvage treatment in advanced biliary tract cancer: an open-label, single arm, phase 2 trial
BackgroundNo standard treatment is available for advanced biliary tract cancer (BTC) after first-line therapy with gemcitabine plus cisplatin...
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Tissue of origin prediction for cancer of unknown primary using a targeted methylation sequencing panel
RationaleCancer of unknown primary (CUP) is a group of rare malignancies with poor prognosis and unidentifiable tissue-of-origin. Distinct DNA...
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Risk factors for antibiotic resistance and mortality in patients with bloodstream infection of Escherichia coli
This study aimed to investigate the risk factors for bloodstream infection (BSI) caused by extended-spectrum beta-lactamase (ESBL)–producing Escherichi...
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Signaling pathways in liver cancer: pathogenesis and targeted therapy
Liver cancer remains one of the most prevalent malignancies worldwide with high incidence and mortality rates. Due to its subtle onset, liver cancer...
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Pan-cancer analysis of whole-genome doubling and its association with patient prognosis
BackgroundWhole-genome doubling (WGD) is a common mutation in cancer. Various studies have suggested that WGD is associated with a poor prognosis in...
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Intratumor microbiome in cancer progression: current developments, challenges and future trends
Cancer is a complicated disease attributed to multifactorial changes, which causes difficulties with treatment strategies. Various factors have been...
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Genetic Instability and Cancer
Cancer cells have a high degree of genomic plasticity, a characteristic that endows them with the dangerous ability to adapt to new environmental...
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Risks of second non-breast primaries following breast cancer in women: a systematic review and meta-analysis
BackgroundSecond primary cancer incidence is rising among breast cancer survivors. We examined the risks of non-breast second primaries, in...
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Targeting Reactive Oxygen Species (ROS) for Cancer Therapy
Reactive oxygen species (ROS) are the highly reactive molecules that play vital roles in cancer progression as well as in the regulation of important...
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A deep learning algorithm to predict risk of pancreatic cancer from disease trajectories
Pancreatic cancer is an aggressive disease that typically presents late with poor outcomes, indicating a pronounced need for early detection. In this...
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Aprepitant inhibits the development and metastasis of gallbladder cancer via ROS and MAPK activation
BackgroundAprepitant, as a neurokinin-1 receptor (NK-1R) antagonist, originally applied for curing chemotherapy-induced nausea and vomiting, has been...
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Targeting TIGIT for cancer immunotherapy: recent advances and future directions
As a newly identified checkpoint, T cell immunoreceptor with immunoglobulin and tyrosine-based inhibitory motif (ITIM) domain (TIGIT) is highly...
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Targeting Reactive Oxygen Species (ROS) for Cancer Therapy
Reactive oxygen species (ROS) are the highly reactive molecules that play vital roles in cancer progression as well as in the regulation of important...
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Microsatellite instability is biased in Amsterdam II-defined Lynch-related cancer cases with family history but is rare in other cancers: a summary of 1000 analyses
BackgroundMicrosatellite instability (MSI) is a key marker for predicting the response of immune checkpoint inhibitors (ICIs) and for screening Lynch...