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Postoperative hyperprogression disease of pancreatic ductal adenocarcinoma after curative resection: a retrospective cohort study
BackgroundPrognosis for patients recurred rapidly after resection of pancreatic ductal adenocarcinoma (PDAC) was extremely poor. We proposed the...
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Progress of Nanotechnology-Based Detection and Treatment of Alzheimer’s Disease Biomarkers
Alzheimer’s disease (AD), responsible for memory loss, language, and learning problems, may lead to a patient’s death. Many biomarkers have been...
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Size matters: the impact of nucleus size on results from spatial transcriptomics
BackgroundVisium Spatial Gene Expression (ST) is a method combining histological spatial information with transcriptomics profiles directly from...
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Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer’s disease
Alzheimer’s disease (AD) is characterized by synaptic loss, which can result from dysfunctional microglial phagocytosis and...
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Development of Humanized Mouse Models for Studying Human NK Cells in Health and Disease
Humanized mice, which we define as immunodeficient mice that have been reconstituted with a human immune system, represent promising preclinical...
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Phenotypic heterogeneity in human genetic diseases: ultrasensitivity-mediated threshold effects as a unifying molecular mechanism
Phenotypic heterogeneity is very common in genetic systems and in human diseases and has important consequences for disease diagnosis and treatment....
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Insulin Deficiency Increases Sirt2 Level in Streptozotocin-Treated Alzheimer’s Disease-Like Mouse Model: Increased Sirt2 Induces Tau Phosphorylation Through ERK Activation
Accumulating evidence suggests that insulin deficiency is a risk factor for Alzheimer’s disease (AD); however, the underlying molecular mechanisms...
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Targeting oxidative stress as a preventive and therapeutic approach for cardiovascular disease
Cardiovascular diseases (CVDs) continue to exert a significant impact on global mortality rates, encompassing conditions like pulmonary arterial...
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Eliminating vascular interference from the Spot Sign contributes to predicting hematoma expansion in individuals with spontaneous cerebral hemorrhages
The computed tomography angiography (CTA) Spot Sign is an effective means of predicting hematoma expansion (HE) in the context of spontaneous...
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In utero origin of myelofibrosis presenting in adult monozygotic twins
The latency between acquisition of an initiating somatic driver mutation by a single-cell and clinical presentation with cancer is largely unknown....
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A Type 3 Gaucher-Like Disease Due To Saposin C Deficiency in Two Emirati Families Caused by a Novel Splice Site Variant in the PSAP Gene
Gaucher disease is caused by glucocerebroside accumulation in different tissues due to beta-glucocerebrosidase enzyme deficiency. Genetic defects in...
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Molecular characterization of a novel cytorhabdovirus infecting Plumbago indica L.
In 2021, Plumbago indica plants with necrotic spots on their leaves were observed in Bei**g, China. Through high-throughput sequencing, we...
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Anti-inflammatory Action of BT75, a Novel RARα Agonist, in Cultured Microglia and in an Experimental Mouse Model of Alzheimer’s Disease
BT75, a boron-containing retinoid, is a novel retinoic acid receptor (RAR)α agonist synthesized by our group. Previous studies indicated that...
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Metabolomics: A Promising Tool to Study Disease Biomarkers and Host-Pathogen Interactions
Metabolomics is a comprehensive analysis of small-molecule metabolite profiles of cellular processes using mass spectrometry combined with advanced...
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Super-resolution microscopy: a closer look at synaptic dysfunction in Alzheimer disease
The synapse has emerged as a critical neuronal structure in the degenerative process of Alzheimer disease (AD), in which the pathogenic signals of...
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Novel Compounds Identified by Structure-Based Prion Disease Drug Discovery Using In Silico Screening Delay the Progression of an Illness in Prion-Infected Mice
The accumulation of abnormal prion protein (PrP Sc ) produced by the structure conversion of PrP (PrP C ) in the brain induces prion disease. Although...
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Cinnamaldehyde Regulates Insulin and Caspase-3 Signaling Pathways in the Sporadic Alzheimer’s Disease Model: Involvement of Hippocampal Function via IRS-1, Akt, and GSK-3β Phosphorylation
Insulin signaling disruption and caspase-3 cleavage play a pathologic role in Alzheimer’s disease (AD). Evidence suggested that cinnamaldehyde (Cin),...
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Multilocus disease-causing genomic variations for Mendelian disorders: role of systematic phenoty** and implications on genetic counselling
Multilocus disease-causing genomic variations (MGVs) and multiple genetic diagnoses (MGDs) are increasingly being recognised in individuals and...
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Recent Advances in Imaging of Preclinical, Sporadic, and Autosomal Dominant Alzheimer’s Disease
Observing Alzheimer’s disease (AD) pathological changes in vivo with neuroimaging provides invaluable opportunities to understand and predict the...