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TRPV1 Suppressed NLRP3 Through Regulating Autophagy in Microglia After Ischemia-Reperfusion Injury
The microglia-mediated inflammatory response is one of the main causes of brain tissue damage after stroke. In recent years, it has been reported...
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Expression of Trpa1 and Trpv1 Genes in the Hypothalamus and Blood Pressure in Normotensive and Hypertensive Rats. Effect of Losartan and Captopril
Analysis of the role of genomic regulation of systolic BP (SBP) in normal and hypertensive rats showed the presence of an inverse relationship...
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Models of Diabetes in Rats: A Focus on Diabetic Neuropathy and Biomarkers
The increased prevalence of diabetic neuropathy (DN), as reported by World Health Organization, is seriously alarming. There is an unmet need to...
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Role of TRPM2 in brain tumours and potential as a drug target
Ion channels are ubiquitously expressed in almost all living cells, and are the third-largest category of drug targets, following enzymes and...
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HDAC inhibitors as a potential therapy for chemotherapy-induced neuropathic pain
Cancer, a chronic disease characterized by uncontrolled cell development, kills millions of people globally. The WHO reported over 10 million cancer...
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Structure-activity relationship of pharmacophores and toxicophores: the need for clinical strategy
ObjectivesSometimes clinical efficacy and potential risk of therapeutic and toxic agents are difficult to predict over a long period of time. Hence...
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Cell-specific NFIA upregulation promotes epileptogenesis by TRPV4-mediated astrocyte reactivity
BackgroundThe astrocytes in the central nervous system (CNS) exhibit morphological and functional diversity in brain region-specific pattern....
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Models of Diabetes in Rats: A Focus on Diabetic Neuropathy and Biomarkers
The increased prevalence of diabetic neuropathy (DN), as reported by World Health Organization, is seriously alarming. There is an unmet need to...
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Neural Mechanisms Underlying the Coughing Reflex
Breathing is an intrinsic natural behavior and physiological process that maintains life. The rhythmic exchange of gases regulates the delicate...
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Function and Regulation of the Calcium-Activated Chloride Channel Anoctamin 1 (TMEM16A)
Various human tissues express the calcium-activated chloride channel Anoctamin 1 (ANO1), also known as TMEM16A. ANO1 allows the passive chloride flux...
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Peripheral receptors and neuromediators involved in the antihyperalgesic effects of acupuncture: a state-of-the-art review
The present study aims to describe state-of-the-art of preclinical studies that have investigated peripheral receptors and neuromediators involved in...
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Novel TRPV6 mutations in the spectrum of transient neonatal hyperparathyroidism
Maternal–fetal calcium (Ca 2+ ) transport in the placenta plays a critical role in maintaining fetal bone mineralization. Mutations in the gene...
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Role of macrophage-mediated Toll-like receptor 4–interleukin-1R signaling in ectopic tongue pain associated with tooth pulp inflammation
BackgroundThe existence of referred pain and ectopic paresthesia caused by tooth pulp inflammation may make definitive diagnosis difficult and cause...
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Tigliane and daphnane diterpenoids from Thymelaeaceae family: chemistry, biological activity, and potential in drug discovery
Tigliane and daphnane diterpenoids are characteristically distributed in plants of the Thymelaeaceae family as well as the Euphorbiaceae family and...
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Targeting cardiovascular risk factors with eugenol: an anti-inflammatory perspective
Inflammation is a multifaceted biological reaction to a wide range of stimuli, and it has been linked to the onset and progression of chronic...
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Evolution and challenges of opioids in pain management: Understanding mechanisms and exploring strategies for safer analgesics
Opioids traced back to ancient civilizations, have evolved in their usage for acute and chronic pain treatment. Their interaction with the endogenous...
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Using C. elegans to Study the Effects of Toxins in Sensory Ion Channels In Vivo
Caenorhabditis elegans is a powerful animal model in which transgenesis, behavior, and physiology can be merged to study in vivo the effect of...
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Chemokine CCL2 prevents opioid-induced inhibition of nociceptive synaptic transmission in spinal cord dorsal horn
BackgroundOpioid analgesics remain widely used for pain treatment despite the related serious side effects. Some of those, such as opioid tolerance...
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Therapeutic Molecular Insights into the Active Engagement of Cannabinoids in the Therapy of Parkinson’s Disease: A Novel and Futuristic Approach
Parkinson’s disease is a neurodegenerative disorder which is characterised mostly by loss of dopaminergic nerve cells throughout the nigral area...
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Inflammation-induced TRPV4 channels exacerbate blood–brain barrier dysfunction in multiple sclerosis
BackgroundBlood–brain barrier (BBB) dysfunction and immune cell migration into the central nervous system (CNS) are pathogenic drivers of multiple...
