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Pan-transcriptome reveals a large accessory genome contribution to gene expression variation in yeast
Gene expression is an essential step in the translation of genotypes into phenotypes. However, little is known about the transcriptome architecture...
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The mixed liver and kidney transcriptome dataset of Darevskia valentini rock lizard
ObjectivesThis study is performed in the frame of a bigger study dedicated to genomics and transcriptomics of parthenogenesis in vertebrates. Among...
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Sample Preparation and Differential Gene Expression Analysis of Human Cancer Cell Lines by RNA Sequencing
RNA sequencing (RNA-seq) is a method used for the high-throughput quantification of mRNA in a biological sample. It is widely used to investigate...
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The application of long-read sequencing in clinical settings
Long-read DNA sequencing technologies have been rapidly evolving in recent years, and their ability to assess large and complex regions of the genome...
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Single-cell and bulk transcriptome sequencing identifies two epithelial tumor cell states and refines the consensus molecular classification of colorectal cancer
The consensus molecular subtype (CMS) classification of colorectal cancer is based on bulk transcriptomics. The underlying epithelial cell diversity...
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A single-cell transcriptome atlas of human euploid and aneuploid blastocysts
Aneuploidy is frequently detected in early human embryos as a major cause of early pregnancy failure. However, how aneuploidy affects cellular...
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Research progress and application of single-cell sequencing in head and neck malignant tumors
Single-cell sequencing (SCS) is a technology that separates thousands of cells from the organism and accurately analyzes the genetic material...
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Single-cell immune repertoire sequencing of B and T cells in murine models of infection and autoimmunity
Adaptive immune repertoires are composed by the ensemble of B and T-cell receptors within an individual, reflecting both past and current immune...
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Transcriptome analysis of intestine from alk-SMase knockout mice reveals the effect of alk-SMase
ObjectiveIntestinal alkaline sphingomyelinase (alk-SMase) generates ceramide and inactivates platelet-activating factor associated with digestion and...
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Single-Cell RNA-Sequencing in Astrocyte Development, Heterogeneity, and Disease
Astrocytes are the most plentiful cell type in the central nervous system (CNS) and perform complicated functions in health and disease. It is...
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Single-Cell Sequencing Technologies in Precision Oncology
Single-cell sequencing technologies are revolutionizing cancer research and are poised to become the standard for translational cancer studies....
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Integrative analysis of spatial and single-cell transcriptome data from human pancreatic cancer reveals an intermediate cancer cell population associated with poor prognosis
BackgroundRecent studies using single-cell transcriptomic analysis have reported several distinct clusters of neoplastic epithelial cells and...
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Identifying Network Biomarkers for Alzheimer’s Disease Using Single-Cell RNA Sequencing Data
System-level network-based approaches are an emerging field in the biomedical domain since biological networks can be used to analyze complicated...
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Sex differences in the transcriptome of extracellular vesicles secreted by fetal neural stem cells and effects of chronic alcohol exposure
BackgroundPrenatal alcohol (ethanol) exposure (PAE) results in brain growth restriction, in part, by reprogramming self-renewal and maturation of...
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VIsoQLR: an interactive tool for the detection, quantification and fine-tuning of isoforms in selected genes using long-read sequencing
DNA variants altering the pre-mRNA splicing process represent an underestimated cause of human genetic diseases. Their association with disease...
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Transcriptome sequencing reveals a lncRNA–mRNA interaction network in extramammary Paget’s disease
BackgroundExtramammary Paget’s disease (EMPD) is a rare malignant intraepidermal adenocarcinoma that is poorly understood. Regulatory long noncoding...
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Sequencing-based analysis of microbiomes
Microbiomes occupy a range of niches and, in addition to having diverse compositions, they have varied functional roles that have an impact on...
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Clinical applications of metagenomics next-generation sequencing in infectious diseases
Infectious diseases are a great threat to human health. Rapid and accurate detection of pathogens is important in the diagnosis and treatment of...
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Single-cell sequencing technology applied to epigenetics for the study of tumor heterogeneity
BackgroundPrevious studies have traditionally attributed the initiation of cancer cells to genetic mutations, considering them as the fundamental...
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Single-Cell Transcriptome Reveals Cell Type–Specific Molecular Pathology in a 2VO Cerebral Ischemic Mouse Model
Post-ischemia memory impairment is a major sequela in cerebral ischemia patients. However, cell type–specific molecular pathology in the hippocampus...
