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ACEIs, ARBs, ibuprofen originally linked to COVID-19: the other side of the mirror
During the COVID-19 pandemic, a correspondence, published at the Lancet Respiratory Medicine, that linked angiotensin-converting enzyme inhibitors,...
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HDL and Diabetes
Diabetes is a worldwide public health issue, with the number of cases expected to reach 642 million by 2040. Patients with diabetes are at a two- to...
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Mitochondrial Dysfunction as a Signaling Target for Therapeutic Intervention in Major Neurodegenerative Disease
Neurodegenerative diseases (NDD) are incurable and the most prevalent cognitive and motor disorders of elderly. Mitochondria are essential for a wide...
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Drug Resistance in Diabetes
The rise in the number of diabetic patients with each passing day give rise to a disturbing situation as serious complications including renal...
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Astaxanthin treatment decreases pro‐inflammatory cytokines and improves reproductive outcomes in patients with polycystic ovary syndrome undergoing assisted reproductive technology: A randomized clinical trial
Research questionIn a randomized, triple-blind, placebo-controlled clinical trial (RCT), we investigated the effect of astaxanthin (AST) on...
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Prioritizing the glucose-lowering medicines for type 2 diabetes by an extended fuzzy decision-making approach with target-based attributes
Different therapeutic classes have been authorized for the treatment of hyperglycemia in type 2 diabetic patients, and even more drug classes are...
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Establishment and evaluation of a novel practical tool for the diagnosis of pre-sarcopenia in young people with diabetes mellitus
ObjectiveSarcopenia has been recognized as a third category of complications in people with diabetes. However, few studies focus on the reduction of...
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Assessment of the α-glucosidase and α-amylase inhibitory potential of Paliurus spina-christi Mill. and its terpenic compounds
Type II diabetes mellitus is a common disease in the world and characterized by hyperglycemia. Prevention of diabetes by reducing hyperglycemia...
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Preventive and Therapeutic Role of Probiotics in Type-2 Diabetes and Its Associated Complications
Our lifestyle and dietary structure have changed significantly due to rapid economic growth and improvement of living standards, accelerating...
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Sex Differences in Glucose Homeostasis
Sexual dimorphism has been demonstrated to have an effect on various physiological functions. In this regard, researchers have investigated its...
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SIRT6 in Regulation of Mitochondrial Damage and Associated Cardiac Dysfunctions: A Possible Therapeutic Target for CVDs
Cardiovascular diseases (CVDs) can be described as a global health emergency imploring possible prevention strategies. Although the pathogenesis of...
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The role of PPARγ in prostate cancer development and progression
Advanced and metastatic prostate cancer is often incurable, but its dependency on certain molecular alterations may provide the basis for targeted...
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Therapeutic Potential of Semaglutide, a Newer GLP-1 Receptor Agonist, in Abating Obesity, Non-Alcoholic Steatohepatitis and Neurodegenerative diseases: A Narrative Review
IntroductionSemaglutide, a peptidic GLP-1 receptor agonist, has been clinically approved for treatment of type 2 diabetes mellitus and is available...
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Insulin Resistance and Diabetes
In this chapter, we will describe the molecular principles of glucose homeostasis and insulin signaling as well as their dysregulation leading to...
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NL-1 Promotes PINK1-Parkin-Mediated Mitophagy Through MitoNEET Inhibition in Subarachnoid Hemorrhage
NL-1 is a mitoNEET ligand known for its antileukemic effects and has recently shown neuroprotective effects in an ischemic stroke model. However, its...
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Sex differences in the association between adipose insulin resistance and non-alcoholic fatty liver disease in Chinese adults
BackgroundAdipose insulin resistance (Adipo-IR) is associated with multiple metabolic diseases, including non-alcoholic fatty liver disease (NAFLD)....
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Type 2 Diabetes (T2DM) and Parkinson’s Disease (PD): a Mechanistic Approach
Growing evidence suggest that there is a connection between Parkinson’s disease (PD) and insulin dysregulation in the brain, whilst the connection...
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Berberine ameliorates glucocorticoid-induced hyperglycemia: an in vitro and in vivo study
Berberine (BBR), a bioactive compound isolated from Coptidis Rhizoma, possesses diverse pharmacological activities including anti-bacterial,...
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Measures of Endothelial Function in Type 2 Diabetes: A Focus on Non-circulatory Methods of Measurement
The endothelium is a vital organ important for regulating vascular homeostasis. Endothelial dysfunction in type 2 diabetes has been linked to the...
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The role of BCAA metabolism in metabolic health and disease
It has long been postulated that dietary restriction is beneficial for ensuring longevity and extending the health span of mammals, including humans....
