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Effects of Aging and Associated Conditions on Humoral Responses to Respiratory Tract Infections
Aging is associated with increased respiratory tract infections (RTIs) to which immunosenescence and inflammaging, the chronic low-grade systemic...
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COL5A2 is a prognostic-related biomarker and correlated with immune infiltrates in gastric cancer based on transcriptomics and single-cell RNA sequencing
BackgroundThere is still a therapeutic challenge in treating gastric cancer (GC) due to its high incidence and poor prognosis. Collagen type V alpha...
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Identification of novel cell-free RNAs in maternal plasma as preterm biomarkers in combination with placental RNA profiles
BackgroundPreterm birth (PTB) is the main driver of newborn deaths. The identification of pregnancies at risk of PTB remains challenging, as the...
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Patient stratification based on urea cycle metabolism for exploration of combination immunotherapy in colon cancer
BackgroundOwing to the low ratio of patients benefitting from immunotherapy, patient stratification becomes necessary. An accurate patient...
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CHSY3 promotes proliferation and migration in gastric cancer and is associated with immune infiltration
BackgroundThe glycosyltransferase CHSY3 is a CHSY family member, yet its importance in the context of gastric cancer development remains incompletely...
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A novel cuproptosis-related gene model predicts outcomes and treatment responses in pancreatic adenocarcinoma
BackgroundCuproptosis is recently emerging as a hot spot in cancer research. However, its role in pancreatic adenocarcinoma (PAAD) has not yet been...
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Role of oncogenic KRAS in the prognosis, diagnosis and treatment of colorectal cancer
Colorectal cancer (CRC) is a heterogeneous disease at the cellular and molecular levels. Kirsten rat sarcoma ( KRAS ) is a commonly mutated oncogene in...
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Robust machine−learning based prognostic index using cytotoxic T lymphocyte evasion genes highlights potential therapeutic targets in colorectal cancer
BackgroundA minute fraction of patients stands to derive substantial benefits from immunotherapy, primarily attributable to immune evasion. Our...
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Comprehensive characterization of m6A methylation and its impact on prognosis, genome instability, and tumor microenvironment in hepatocellular carcinoma
BackgroundN6-methyladenosine (m6A) RNA regulation was recently reported to be important in carcinogenesis and cancer development. However, the...
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CSPG4 expression in soft tissue sarcomas is associated with poor prognosis and low cytotoxic immune response
BackgroundSoft tissue sarcomas (STS) are heterogeneous and pro-metastatic tumors. Identification of accurate prognostic factors and novel therapeutic...
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Choline metabolism reprogramming mediates an immunosuppressive microenvironment in non-small cell lung cancer (NSCLC) by promoting tumor-associated macrophage functional polarization and endothelial cell proliferation
IntroductionLung cancer is a prevalent malignancy globally, and immunotherapy has revolutionized its treatment. However, resistance to immunotherapy...
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Expression of hub genes of endothelial cells in glioblastoma-A prognostic model for GBM patients integrating single-cell RNA sequencing and bulk RNA sequencing
BackgroundThis study aimed to use single-cell RNA-seq (scRNA-seq) to discover marker genes in endothelial cells (ECs) and construct a prognostic...
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Identification and validation of eight lysosomes-related genes signatures and correlation with immune cell infiltration in lung adenocarcinoma
Lung cancer is the leading cause of cancer-related death. Lysosomes are key degradative compartments that maintain protein homeostasis. In current...
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T-Cell Activation and Differentiation: Role of Signaling and Metabolic Cross-Talk
Different types of T effector cells function centrally in the immune-regulatory network, which acts as a line of defense for the body and elicits...
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Genomic analysis and filtration of novel prognostic biomarkers based on metabolic and immune subtypes in pancreatic cancer
PurposePatients with pancreatic cancer (PC) can be classified into various molecular subtypes and benefit from some precise therapy. Nevertheless,...
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A novel immune checkpoints-based signature to predict prognosis and response to immunotherapy in lung adenocarcinoma
BackgroundExcept for B7-CD28 family members, more novel immune checkpoints are being discovered. They are closely associated with tumor immune...
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A Machine Learning Computational Framework Develops a Multiple Programmed Cell Death Index for Improving Clinical Outcomes in Bladder Cancer
Comprehensive action patterns of programmed cell death (PCD) in bladder cancer (BLCA) have not yet been thoroughly investigated. Here, we collected...
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Necroptosis-related LncRNAs in skin cutaneous melanoma: evaluating prognosis, predicting immunity, and guiding therapy
BackgroundAn increasing amount of research has speculated that necroptosis could be a therapeutic strategy for treating cancer. However,...
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Characterization of genomic instability-related genes predicts survival and therapeutic response in lung adenocarcinoma
BackgroundLung adenocarcinoma (LUAD) is the most common subtype of non-small cell lung cancer (NSCLC) and is the leading cause of cancer death...
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A PfSPZ vaccine immunization regimen equally protective against homologous and heterologous controlled human malaria infection
Immunization with radiation-attenuated Plasmodium falciparum (Pf) sporozoites (SPZ) in PfSPZ Vaccine, has provided better vaccine efficacy (VE)...
