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The Role of Inflammation in the Development of Diabetic Polyneuropathy and the Potential for Its Correction
Objectives. To study the efficacy of the drug Cytoflavin in patients with diabetic polyneuropathy (DPN) by assessing the blood tumor necrosis...
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Coexistence of chronic hyperalgesia and multilevel neuroinflammatory responses after experimental SCI: a systematic approach to profiling neuropathic pain
BackgroundPeople with spinal cord injury (SCI) frequently develop neuropathic pain (NP) that worsens disability and diminishes rehabilitation...
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Toll-like receptors and their role in neuropathic pain and migraine
Migraine is a complex neurological disease of unknown etiology involving both genetic and environmental factors. It has previously been reported that...
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Estrogenic impregnation alters pain expression: analysis through functional neuropeptidomics in a surgical rat model of osteoarthritis
PurposeSeveral observational studies suggest that estrogens could bias pain perception. To evaluate the influence of estrogenic impregnation on pain...
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Trans-synaptic spreading of alpha-synuclein pathology through sensory afferents leads to sensory nerve degeneration and neuropathic pain
Pain is a common non-motor symptom of Parkinson’s disease (PD), with current limited knowledge of its pathophysiology. Here, we show that peripheral...
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Inflammatory Mediators, Nociceptors, and Their Interactions in Pain
Inflammation produces pro-inflammatory mediators for the induction of pain. These mediators include inflammatory cytokines and chemokines, lipids,...
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Neuroplasticity related to chronic pain and its modulation by microglia
Neuropathic pain is often chronic and can persist after overt tissue damage heals, suggesting that its underlying mechanism involves the alteration...
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HDAC inhibitors as a potential therapy for chemotherapy-induced neuropathic pain
Cancer, a chronic disease characterized by uncontrolled cell development, kills millions of people globally. The WHO reported over 10 million cancer...
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A Guide to Preclinical Models of Zoster-Associated Pain and Postherpetic Neuralgia
Reactivation of latent varicella-zoster virus (VZV) causes herpes zoster (HZ), which is commonly accompanied by acute pain and pruritus over the time...
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Qualia, Brain Waves, and Spinal Reflexes: The Study of Pain Perception by Means of Subjective Reports, Electroencephalography, and Electromyography
Pain is defined as an inherently conscious multidimensional experience, which is traditionally studied using psychophysical methods. Pain threshold,...
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H
Also known as hafgerdingar effect. Hafgerðingar is Old Norse for ‘sea hedges’ or ‘sea fences’. The term denotes a circular *physical illusion...
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Pharmaceutical perspective of neuropathic pain management for primary care providers
Neuropathic pain (NP) is a chronic condition that affects ~ 1% of the general population globally. Several conditions such as chronic diabetes,...
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Targeting Large-Conductance Calcium-Activated Potassium Channels to Ameliorate Lipopolysaccharide-Induced Depressive-Like Behavior in Mice
Neuroinflammation plays crucial role in the development and progression of depression. Large conductance calcium- and voltage-dependent potassium...
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Chemotherapy-Induced Peripheral Neuropathy: Mechanisms and Therapeutic Avenues
Chemotherapy-induced peripheral neuropathy (CIPN) is a serious and often persistent adverse consequence of certain chemotherapeutic agents. It is a...
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Design and Evaluation of Continentalic Acid Encapsulated Transfersomal Gel and Profiling of its Anti-arthritis Activity
Rheumatoid arthritis restricts the physical ability of patients and increases the disease burden; therefore, research has always been focused on...
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CXCL10/CXCR3 Signaling in the DRG Exacerbates Neuropathic Pain in Mice
Chemokines and receptors have been implicated in the pathogenesis of chronic pain. Here, we report that spinal nerve ligation (SNL) increased CXCR3...
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Pain-induced impulsivity is sexually dimorphic and mu-opioid receptor sensitive in rats
Rationale and objectivesPain sensation can negatively impact cognitive function, including impulsivity. Pain-induced changes in impulsivity can...
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Involvement of P2X7 receptors in chronic pain disorders
Chronic pain is caused by cellular damage with an obligatory inflammatory component. In response to noxious stimuli, high levels of ATP leave...
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The Sigma 2 receptor promotes and the Sigma 1 receptor inhibits mu-opioid receptor-mediated antinociception
The Sigma-1 receptor (σ1R) has emerged as an interesting pharmacological target because it inhibits analgesia mediated by mu-opioid receptors (MOR),...
