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An ANOCEF genomic and transcriptomic microarray study of the response to radiotherapy or to alkylating first-line chemotherapy in glioblastoma patients
BackgroundThe molecular characteristics associated with the response to treatment in glioblastomas (GBMs) remain largely unknown. We performed a...
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Genetics and cardiac channelopathies
Abstract: Sudden cardiac death is a major contributor to mortality in industrialized nations; in fact, it is the cause of more deaths than acquired...
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Nitric Oxide and Life or Death of Human Leukemia Cells
Nitric oxide (NO) has many actions that affect physiologic and pathologic processes. These effects are important in maintenance of appropriate smooth...
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Myofibril-Inducing RNA (MIR) is essential for tropomyosin expression and myofibrillogenesis in axolotl hearts
The Mexican axolotl, Ambystoma mexicanum , carries the naturally-occurring recessive mutant gene 'c' that results in a failure of homozygous (c/c)...
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HERG1 channelopathies
Human ether a go-go-related gene type 1 (hERG1) K + channels conduct the rapid delayed rectifier K + current and mediate action potential...
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Molecular genetics of cardiomyopathies and myocarditis
Cardiomyopathies are major causes of morbidity and mortality and over the past 20 years, limited improvements in outcome have been reported [1—3]....
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Cardiac sodium channelopathies
Cardiac sodium channel are protein complexes that are expressed in the sarcolemma of cardiomyocytes to carry a large inward depolarizing current (I Na )...
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Networking of differentially expressed genes in human cancer cells resistant to methotrexate
BackgroundThe need for an integrated view of data obtained from high-throughput technologies gave rise to network analyses. These are especially...
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Dysbindin-1 and Its Protein Family
Variation in the gene encoding dysbindin-1 (i.e., dystrobrevin-binding protein 1: DTNBP1) has frequently been associated with schizophrenia. Several...
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Role of Aquaporin-4 in Cerebral Edema and Stroke
Cerebral edema plays a central role in the pathophysiology of many diseases of the central nervous system (CNS) including ischemia, trauma, tumors,...
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Olfactomedin Domain-Containing Proteins: Possible Mechanisms of Action and Functions in Normal Development and Pathology
A family of olfactomedin domain-containing proteins consists of at least 13 members in mammals. Although the first protein belonging to this family,...
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The HTLV-1 Tax interactome
The Tax1 oncoprotein encoded by Human T-lymphotropic virus type I is a major determinant of viral persistence and pathogenesis. Tax1 affects a wide...
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Plasma Membrane Calcium ATPase
To function properly, cells must maintain a very low cytosolic free Ca2+ concentration (50–200 nM) in the face of an extracellular concentration,...
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Dp71f Modulates GSK3-β Recruitment to the β1-Integrin Adhesion Complex
Previously, it was shown that Dp71f binds to the β1-integrin adhesion complex to modulate PC12 cell adhesion. The absence of Dp71f led to a failure...
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Approaching a new age in Duchenne muscular dystrophy treatment
Duchenne muscular dystrophy is the most common and severe form of muscular dystrophy. The cornerstones of current treatment include corticosteroids...
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Brain endothelial cells and the glio-vascular complex
We present and discuss the role of endothelial and astroglial cells in managing the blood-brain barrier (BBB) and aspects of pathological alterations...
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Transcriptional patterns, biomarkers and pathways characterizing nasopharyngeal carcinoma of Southern China
BackgroundThe pathogenesis of nasopharyngeal carcinoma (NPC) is a complicated process involving genetic predisposition, Epstein-Bar Virus infection,...
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Stromal gene expression predicts clinical outcome in breast cancer
Although it is increasingly evident that cancer is influenced by signals emanating from tumor stroma, little is known regarding how changes in...
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Animal Models for Genetic Neuromuscular Diseases
The neuromuscular disorders are a heterogeneous group of genetic diseases, caused by mutations in genes coding sarcolemmal, sarcomeric, and citosolic...
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Molecular Organization of the Postsynaptic Membrane at Inhibitory Synapses
The majority of fast inhibitory neurotransmission in the mammalian central nervous system (CNS) is mediated by γ-aminobutyric acid type A receptors...