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OVX836 a recombinant nucleoprotein vaccine inducing cellular responses and protective efficacy against multiple influenza A subtypes
Inactivated influenza vaccines (IIVs) lack broad efficacy. Cellular immunity to a conserved internal antigen, the nucleoprotein (NP), has been...
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Transplant Tolerance: Current Insights and Strategies for Long-Term Survival of Xenografts
Xenotransplantation is an attractive solution to the problem of allograft shortage. However, transplants across discordant species barriers are...
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Biological links between traumatic brain injury and Parkinson’s disease
Parkinson’s Disease (PD) is a progressive neurodegenerative disorder with no cure. Clinical presentation is characterized by postural instability,...
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Application of Support Vector Machines in Viral Biology
Novel experimental and sequencing techniques have led to an exponential explosion and spiraling of data in viral genomics. To analyse such data,...
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The deubiquitinase OTUB1 augments NF-κB-dependent immune responses in dendritic cells in infection and inflammation by stabilizing UBC13
Dendritic cells (DCs) are indispensable for defense against pathogens but may also contribute to immunopathology. Activation of DCs upon the sensing...
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Tissue-enhanced plasma proteomic analysis for disease stratification in amyotrophic lateral sclerosis
BackgroundIt is unclear to what extent pre-clinical studies in genetically homogeneous animal models of amyotrophic lateral sclerosis (ALS), an...
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PA-X: a key regulator of influenza A virus pathogenicity and host immune responses
PA-X, a fusion protein belonging to influenza A viruses (IAVs), integrating the N-terminal 191 amino acids of PA gene and the ribosomal...
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Prediction and in vitro verification of potential CTL epitopes conserved among PRRSV-2 strains
Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) is the causative agent of one of the most important porcine diseases with a high impact...
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Genetically Engineered Large Animals in Biomedicine
Major progress in genetic engineering and genome editing of livestock species has extended their use to biomedical applications, the most notable...
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Vaccine-induced autoimmunity: the role of molecular mimicry and immune crossreaction
Since the early 1800s vaccines have saved numerous lives by preventing lethal infections. However, during the past two decades, there has been...
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Cross-circulation for extracorporeal support and recovery of the lung
The shortage of transplantable donor organs has profound consequences, especially for patients with end-stage lung disease, for which transplantation...
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Immunoregulatory effects triggered by immunobiotic Lactobacillus jensenii TL2937 strain involve efficient phagocytosis in porcine antigen presenting cells
BackgroundImmunobiotic Lactobacillus jensenii TL2937 modulates porcine mononuclear phagocytes from Peyer’s patches (PPMPs) and induces a...
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Therapeutic application of T regulatory cells in composite tissue allotransplantation
With growing number of cases in recent years, composite tissue allotransplantation (CTA) has been improving the quality of life of patient who seeks...
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Preferred SLA class I/class II haplotype combinations in German Landrace pigs
Major histocompatibility complex (MHC) molecules are responsible for the antigen presentation to T lymphocytes. High recombination rates in the MHC...
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Recognizing conserved non-canonical localization patterns of toll-like receptors in tissues and across species
Toll-like receptors (TLR) 1, 2, 4, 5 and 6 were originally characterized as exclusively expressed on the cell surface and TLR 3, 7, 8 and 9 were said...
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HLA-DRB1 the notorious gene in the mosaic of autoimmunity
The major histocompatibility complex system is the most polymorphic gene cluster of the mammal genome. In humans, this is a genomic locus known as...
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Introduction to RNA Vaccines
RNA vaccines are attractive, because they exhibit characteristics of subunit vaccines and live-attenuated vectors, including flexible production and...
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A modern approach for epitope prediction: identification of foot-and-mouth disease virus peptides binding bovine leukocyte antigen (BoLA) class I molecules
Major histocompatibility complex (MHC) class I molecules regulate adaptive immune responses through the presentation of antigenic peptides to CD8+ T...
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Aujeszky’s Disease
Aujeszky’s disease (AD) or pseudorabies (PR), also referred as “mad itch,” is a highly contagious, economically significant disease of pigs caused by...
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The orthologs of HLA-DQ and -DP genes display abundant levels of variability in macaque species
The human major histocompatibility complex (MHC) region encodes three types of class II molecules designated HLA-DR, -DQ, and -DP. Both the HLA-DQ ...
