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Blood-based therapies to combat neurodegenerative diseases
Neurodegeneration, known as the progressive loss of neurons in terms of their structure and function, is the principal pathophysiological change...
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Synthetic-Based Tumor-Infiltrating Lymphocytes (TILs) in Adoptive Cell Therapies
Cancer is a complex microenvironment, characterized by dynamic reciprocal communication between tumor cells, tumor-associated immune cells, and other...
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Human mesenchymal stem cell secretomes: Factors affecting profiling and challenges in clinical application
The promising field of regenerative medicine is thrilling as it can repair and restore organs for various debilitating diseases. Mesenchymal stem...
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A postnatal network of co-hepato/pancreatic stem/progenitors in the biliary trees of pigs and humans
A network of co-hepato/pancreatic stem/progenitors exists in pigs and humans in Brunner’s Glands in the submucosa of the duodenum, in peribiliary...
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Comparison of retinal degeneration treatment with four types of different mesenchymal stem cells, human induced pluripotent stem cells and RPE cells in a rat retinal degeneration model
BackgroundRetinal degeneration (RD) is a group of disorders on irreversible vision loss. Multiple types of stem cells were used in clinical trials...
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Cell and Gene Therapies for Chronic Inflammatory Lung Diseases: Emerging Technological Trends and Advancements in Respiratory Medicine
Inflammatory lung diseases pose a tremendous socioeconomic burden to the families and also the community healthcare system. It was estimated that a...
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Cancer Stem Cell as a Target for Immunotherapeutic Approach
In today’s world, immunotherapy is known as revolutionary in cancer treatment. Until now, many clinical trials tried to find different targets for...
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Stem Cell-Based Products in the Market
There has been considerable attention paid to cutaneous stem cell in the area of regenerative medicineRegenerative medicine as a potential...
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Exploiting in silico modelling to enhance translation of liver cell therapies from bench to bedside
Cell therapies are emerging as promising treatments for a range of liver diseases but translational bottlenecks still remain including: securing and...
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Development of Mesenchymal Stem Cells Therapy for the Treatment of Polyglutamine SCA: From Bench to Bedside
This chapter focuses on the clinical application of mesenchymal stem cells (MSCs) for the treatment of spinocerebellar ataxia (SCA). SCA is a...
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An Overview of Antioxidative Anticancer Therapies with Reference to the Cancer Stem Cells
Reactive species comprise a group of molecules that are generated as byproducts of various eukaryotic metabolic reactions. They are known to regulate...
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Mesenchymal Stem Cells
Tumor microenvironment (TME) is a complex network with a heterogeneous ensemble of cancer cells, mesenchymal stromal/stem cells (MSCs), inflammatory...
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Mesenchymal Stem Cells
Tumor microenvironment (TME) is a complex network with a heterogeneous ensemble of cancer cells, mesenchymal stromal/stem cells (MSCs), inflammatory...
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CAR T cell-based immunotherapy and radiation therapy: potential, promises and risks
CAR T cell-based therapies have revolutionized the treatment of hematological malignancies such as leukemia and lymphoma within the last years. In...
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Stem cell-based therapy for hirschsprung disease, do we have the guts to treat?
Hirschsprung disease (HSCR) is a congenital anomaly of the colon that results from failure of enteric nervous system formation, leading to a...
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Neuroprotection of Stem Cells Against Ischemic Brain Injury: From Bench to Clinic
Neurological injuries can have numerous debilitating effects on functional status including sensorimotor deficits, cognitive impairment, and...
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Retinal Organoids: A Human Model System for Development, Diseases, and Therapies
Inherited retinal degenerations (IRD) encompasses a group of heterogeneous disorders causing debilitating visual diseases and blindness, affecting...
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Adipose-Derived Stem Cells
Adipose-derived stem cells (ADSCs) represent a stem cell population found in adipose tissue, relatively easy to harvest, which have been the focus of...
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Research Advances in Stem Cell Therapy for Erectile Dysfunction
Erectile dysfunction (ED) is a common clinical condition that mainly affects men aged over 40 years. Various causes contribute to the progression of...
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Adipose-Derived Stem Cells
Adipose-derived stem cells (ADSCs) represent a stem cell population found in adipose tissue, relatively easy to harvest, which have been the focus of...