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Antiplasmodial natural products: an update
BackgroundMalaria remains a significant public health challenge in regions of the world where it is endemic. An unprecedented decline in malaria...
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Topically Applied Ceramides Interact with the Stratum Corneum Lipid Matrix in Compromised Ex Vivo Skin
PurposeTo determine whether formulations containing ceramides (including a ceramide with a long hydroxyl acyl chain linked to a linoleate, CER EOS)...
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Ceramide and Its Related Neurochemical Networks as Targets for Some Brain Disorder Therapies
Correlational and causal comparative research link ceramide (Cer), the precursor of complex sphingolipids, to some psychiatric (e.g., depression,...
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Lipid and Membrane Structures
Lipids are small hydrophobic or amphipathic molecules that may entirely or in part originate by carbanion-based condensations of thioesters and/or by...
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Exploring the Therapeutic Landscape of Sphingomyelinases
Sphingosine, ceramide, sphingosine-1-phosphate, and other related sphingolipids have emerged as important bioactive molecules involved in a variety...
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MicroRNA-338-3p suppresses cell proliferation and induces apoptosis of non-small-cell lung cancer by targeting sphingosine kinase 2
BackgroundLung cancer is the major cause of cancer-related death worldwide, and 80% patients of lung cancer are non-small-cell lung cancer (NSCLC)...
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Lipid Profiling by Supercritical Fluid Chromatography/Mass Spectrometry
Supercritical fluid chromatography (SFC) is a promising separation technique for comprehensive lipid profiling, or lipidomics. SFC facilitates...
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Exercise increases sphingoid base-1-phosphate levels in human blood and skeletal muscle in a time- and intensity-dependent manner
PurposeSphingosine-1-phosphate (S1P) regulates cardiovascular function and plays an important role in muscle biology. We have previously reported...
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Sphingolipid metabolism potential in fecal microbiome and bronchiolitis in infants: a case–control study
ObjectiveEmerging evidence demonstrated that the structure of fecal microbiome is associated with the likelihood of bronchiolitis in infants....
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Lipid Metabolism, Lipid Signalling and Longevity
Ageing research gains more attention as the aged population increases worldwide and ageing-related diseases become more prevalent. Model organism...
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Biological Effects of Naturally Occurring Sphingolipids, Uncommon Variants, and Their Analogs
Sphingolipids (SPs) comprise a highly diverse class of lipids that serve biological roles both as structural components of cell membranes and as...
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The CD1 family: serving lipid antigens to T cells since the Mesozoic era
Class I-like CD1 molecules are in a family of antigen-presenting molecules that bind lipids and lipopeptides, rather than peptides for immune...
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Cellular Organization of the Gastrointestinal Tract
The gastrointestinal (GI) tract is composed of basic tissue types (epithelia, connective, blood, lymphatic, muscle, and nerve tissue) formed from...
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Advanced Shotgun Lipidomics for Characterization of Altered Lipid Patterns in Neurodegenerative Diseases and Brain Injury
Multi-dimensional mass spectrometry-based shotgun lipidomics (MDMS-SL) is a powerful technology platform among current lipidomics practices due to...
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Stratum Corneum
The stratum corneum, consisting of denucleated keratinocytes, corneocytes that are eventually shed from skin, is a highly-functional outer layer of...
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