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Neurovascular dysfunction in GRN-associated frontotemporal dementia identified by single-nucleus RNA sequencing of human cerebral cortex
Frontotemporal dementia (FTD) is the second most prevalent form of early-onset dementia, affecting predominantly frontal and temporal cerebral lobes....
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Using single-nucleus RNA-sequencing to interrogate transcriptomic profiles of archived human pancreatic islets
BackgroundHuman pancreatic islets are a central focus of research in metabolic studies. Transcriptomics is frequently used to interrogate alterations...
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Optogenetic Inhibition of Glutamatergic Neurons in the Dysgranular Posterior Insular Cortex Modulates Trigeminal Neuropathic Pain in CCI-ION Rat
In individuals with chronic neuropathic pain, the posterior insular cortex (PIC) has been found to exhibit increased glutamatergic activity, and the...
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Spatially restricted drivers and transitional cell populations cooperate with the microenvironment in untreated and chemo-resistant pancreatic cancer
Pancreatic ductal adenocarcinoma is a lethal disease with limited treatment options and poor survival. We studied 83 spatial samples from 31 patients...
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Single-nucleus multiregion transcriptomic analysis of brain vasculature in Alzheimer’s disease
Cerebrovascular dysregulation is a hallmark of Alzheimer’s disease (AD), but the changes that occur in specific cell types have not been fully...
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Where is Waldo? or find the platelet
Platelets evolved from nucleated thrombocytes that exhibit both coagulation and immune function. The essential role of platelets in coagulation is...
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Map** the genetic architecture of human traits to cell types in the kidney identifies mechanisms of disease and potential treatments
The functional interpretation of genome-wide association studies (GWAS) is challenging due to the cell-type-dependent influences of genetic variants....
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Spatial and cell type transcriptional landscape of human cerebellar development
The human neonatal cerebellum is one-fourth of its adult size yet contains the blueprint required to integrate environmental cues with develo**...
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Decoding molecular and cellular heterogeneity of mouse nucleus accumbens
The nucleus accumbens (NAc) plays an important role in regulating multiple behaviors, and its dysfunction has been linked to many neural disorders....
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Linking unfolded protein response to ovarian cancer cell fusion
BackgroundPolyploid giant cancer cells (PGCCs) have been observed in epithelial ovarian tumors. They can resist antimitotic drugs, thus participating...
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Germ plasm and the origin of the primordial germ cells in the oriental river prawn Macrobrachium nipponense
Germ plasm is a special cytoplasmic component containing special RNAs and proteins, and is located in specific regions of oocytes and embryos. Only...
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Engineering Approaches in Ovarian Cancer Cell Culture
Determination of the frequency of somatic mutations, copy number variations, and the composition of single-nucleus transcriptomes in epithelial...
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Candelabrum cells are ubiquitous cerebellar cortex interneurons with specialized circuit properties
To understand how the cerebellar cortex transforms mossy fiber (MF) inputs into Purkinje cell (PC) outputs, it is vital to delineate the elements of...
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Morphological evidence for multiple distinct channels of corticogeniculate feedback originating in mid-level extrastriate visual areas of the ferret
Complementary reciprocal feedforward and feedback circuits connecting the visual thalamus with the visual cortex are essential for visual perception....
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Functionally distinct POMC-expressing neuron subpopulations in hypothalamus revealed by intersectional targeting
Pro-opiomelanocortin (POMC)-expressing neurons in the arcuate nucleus of the hypothalamus represent key regulators of metabolic homeostasis....
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Parthenogenetic mosaicism: generation via second polar body retention and unmasking of a likely causative PER2 variant for hypersomnia
BackgroundParthenogenetic mosaicism is an extremely rare condition identified only in five subjects to date. The previous studies indicate that this...
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Role of Reactive Astrocytes in Alzheimer’s Disease
Astrocytes respond to any pathological stimulus to the central nervous system including in Alzheimer’s disease (AD). They undergo dramatic remodeling...
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Single-cell deconvolution algorithms analysis unveils autocrine IL11-mediated resistance to docetaxel in prostate cancer via activation of the JAK1/STAT4 pathway
BackgroundDocetaxel resistance represents a significant obstacle in the treatment of prostate cancer. The intricate interplay between cytokine...
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Single-cell transcriptomic analysis of the adult mouse spinal cord reveals molecular diversity of autonomic and skeletal motor neurons
The spinal cord is a fascinating structure that is responsible for coordinating movement in vertebrates. Spinal motor neurons control muscle activity...
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Chromothripsis as an on-target consequence of CRISPR–Cas9 genome editing
Genome editing has therapeutic potential for treating genetic diseases and cancer. However, the currently most practicable approaches rely on the...
