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Association between admission plasma 2-oxoglutarate levels and short-term outcomes in patients with acute heart failure: a prospective cohort study
Background2-oxoglutarate (2OG), an intermediate metabolite in the tricarboxylic acid cycle, has been found to associate with chronic heart failure...
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Effect of a 1-year physical activity intervention on cardiovascular health in long-term childhood cancer survivors—a randomised controlled trial (SURfit)
BackgroundThis randomised controlled trial (RCT) assessed the effect of a 1-year, partially supervised, physical activity (PA) intervention on a...
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Impact of a one-year supervised physical activity program on long-term cancer-related fatigue and mediating effects of the gut microbiota in metastatic testicular cancer patients: protocol of the prospective multicentre, randomized controlled phase-III STARTER trial
BackgroundTesticular germ cell tumours (TGCTs) are the most common malignancy in men aged 15–40 years, with increasing incidence worldwide. About...
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Mitochondrial reprogramming in peripheral blood mononuclear cells of patients with glycogen storage disease type Ia
BackgroundGlycogen storage disease type Ia (GSDIa) is an inborn metabolic disorder caused by the deficiency of glucose-6-phospatase-α (G6Pase-α)...
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Comparison of the effects of empagliflozin and sitagliptin, as add-on to metformin, on serum levels of asprosin and metabolic parameters in patients with type 2 diabetes mellitus
The effect of sitagliptin and empagliflozin on serum levels of asprosin and metabolic parameters in patients with type 2 diabetes mellitus (T2DM) was...
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Impact of the gut microbiota and associated metabolites on cardiometabolic traits, chronic diseases and human longevity: a Mendelian randomization study
Features of the gut microbiota have been associated with several chronic diseases and longevity in preclinical models as well as in observational...
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Biomarkers in Experimental Diabetes: Studies with Syzygium Cumini (L.) and Links with the Sulfonylurea 1 Receptor
Diabetes mellitus (DM) is showing a global rise in its incidence. Pancreatic beta cell dysfunction, insulin resistance, and inflammation contribute...
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Current perspectives in obesity management: unraveling the impact of different therapy approach in real life obesity care
BackgroundThe challenge of addressing obesity persists in healthcare, necessitating nuanced approaches and personalized strategies. This study aims...
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Effect of AMY1 copy number variation and various doses of starch intake on glucose homeostasis: data from a cross-sectional observational study and a crossover meal study
BackgroundCopy number (CN) variation (CNV) of the salivary amylase gene ( AMY1 ) influences the ability to digest starch and may influence glucose...
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Predicting 1-, 3-, 5-, and 8-year all-cause mortality in a community-dwelling older adult cohort: relevance for predictive, preventive, and personalized medicine
BackgroundPopulation aging is a global public health issue involving increased prevalence of age-related diseases, and concomitant burden on medical...
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Circulating free insulin-like growth factor-I and prostate cancer: a case-control study nested in the European prospective investigation into cancer and nutrition
BackgroundCirculating total insulin-like growth factor-I (IGF-I) is an established risk factor for prostate cancer. However, only a small proportion...
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Multiband mucosectomy versus endoscopic submucosal dissection and endoscopic submucosal excavation for GI submucosal tumors: short and long term follow-up
AimsTo evaluate the short- and long-term outcomes of 3 different endoscopic dissection techniques for upper gastrointestinal (GI) submucosal tumours...
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Oligofructose improves small intestinal lipid-sensing mechanisms via alterations to the small intestinal microbiota
BackgroundUpper small intestinal dietary lipids activate a gut-brain axis regulating energy homeostasis. The prebiotic, oligofructose (OFS) improves...
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Predictors of acarbose therapeutic efficacy in newly diagnosed type 2 diabetes mellitus patients in China
BackgroundAcarbose is one of the optimal drugs for patients with the first diagnosis of type 2 diabetes mellitus (T2DM). But what kind of emerging...
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Evaluating the inter-species transmission risk of amyloid beta peptide aggregates via ingestion
BackgroundRecent reports suggest that amyloid beta (Aβ) peptides can exhibit prion-like pathogenic properties. Transmission of Aβ peptide and the...
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CCE and EODF as two distinct non-shivering thermogenesis models inducing weight loss
Increasing energy expenditure and reducing energy intake are considered two classical methods to induce weight loss. Weight loss through physical...
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Long-term use of metformin and Alzheimer’s disease: beneficial or detrimental effects
Alzheimer's disease (AD) is the most common neurodegenerative disease characterized by extracellular deposition of amyloid beta (Aβ) leading to...
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Nutritional strategies cause memory damage and alter biochemical parameters without causing neuroinflammation
Obesity results from an energy imbalance and has been considered an epidemic due to its increasing rates worldwide. It is classified as a low-grade...
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Systemic inflammation and insulin resistance-related indicator predicts poor outcome in patients with cancer cachexia
BackgroundThe C-reactive protein (CRP)-triglyceride-glucose (TyG) index (CTI), which is a measure representing the level of inflammation and insulin...
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Current Advances and Future Avenues in Endocrinology
Endocrinology is a dynamic science with numerous advances in the field of diagnosis, prognosis and management. Newer diagnostic modalities in the...