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A 14-year review (2007–2020) of helminthiasis epidemiology in a hospital in Southern Madrid, Spain
PurposeVast majority of helminth diseases remain neglected tropical diseases (NTDs), causing significant morbidity. The widespread and periodic...
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Interleukin (IL)-33 is dispensable for Schistosoma mansoni worm maturation and the maintenance of egg-induced pathology in intestines of infected mice
BackgroundSchistosomes are trematode worms that dwell in their definitive host’s blood vessels, where females lay eggs that need to be discharged...
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Protocols for Preparation and Mass Spectrometry Analysis of Clinical Urine Samples to Identify Candidate Biomarkers of Schistosoma-Associated Bladder Cancer
Advances in mass spectrometry instrumentation have revolutionized analytical capability in clinical proteomics. In parallel, various sample...
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An inside out journey: biogenesis, ultrastructure and proteomic characterisation of the ectoparasitic flatworm Sparicotyle chrysophrii extracellular vesicles
BackgroundHelminth extracellular vesicles (EVs) are known to have a three-way communication function among parasitic helminths, their host and the...
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Human Chemotherapy by China-Made Praziquantel in Zanzibar: Efficacy and Safety
Schistosomiasis is a global neglected tropical parasitic disease of great medical and economic significance. Since praziquantel was developed in...
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Cell therapy as a new approach on hepatic fibrosis of murine model of Schistosoma mansoni-infection
BackgroundSchistosomiasis is an acute and chronic disease of the genus Schistosoma triggered by blood flukes. Schistosomiasis is a disease occurring...
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Testing of Schistosoma mansoni Vaccine Targets
Vaccination has greatly reduced the burden of human diseases caused by infectious pathogens. Systematic development of vaccine targets requires...
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Identification of Schistosoma japonicum GSK3β interacting partners by yeast two-hybrid screening and its role in parasite survival
Schistosoma is the causative agent of schistosomiasis, a common infectious disease distributed worldwide. Our previous phosphoproteomic analysis...
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Interactive online application for the prediction, ranking and prioritisation of drug targets in Schistosoma haematobium
BackgroundHuman schistosomiasis is a neglected tropical disease caused by parasitic worms of the genus Schistosoma that still affects some 200...
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Advances in the study of the interaction between schistosome infections and the host's intestinal microorganisms
Schistosomiasis, also called bilharziasis, is a neglected tropical disease induced by schistosomes that infects hundreds of millions of people...
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Pathogenic Interleukin-10 Receptor Alpha Variants in Humans — Balancing Natural Selection and Clinical Implications
Balancing natural selection is a process by which genetic variants arise in populations that are beneficial to heterozygous carriers, but pathogenic...
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Activation of transient receptor potential channel Sm.(Schistosoma mansoni)TRPMPZQ by PZQ, enhanced Ca++ influx, spastic paralysis, and tegumental disrupture—the deadly cascade in parasitic schistosomes, other trematodes, and cestodes
After almost 50 years of praziquantel (PZQ) research, Park and Marchant (Trends Parasitol 36:182–194,
2020 ) described the Ca ++ -permeable transient...
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Phylogenetic relationship of Prohemistomum vivax to other trematodes based on the internal transcribed spacer region and mitochondrial genes
Prohemistomum vivax is a zoonotic small cyathocotylid trematode that inhabits the intestines of fish-eating birds and mammals. Here, we amplified the...
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Effects of the probiotic Bacillus cereus GM on experimental schistosomiasis mansoni
Probiotics contribute to the integrity of the intestinal mucosa and preventing dysbiosis caused by opportunistic pathogens, such as intestinal...
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Progress in controlling the transmission of schistosome parasites in Southern Ethiopia: the Geshiyaro Project in the Wolaita Zone
BackgroundThis paper describes changes in the prevalence and intensity of schistosome parasite infections in a project integrating mass drug...
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Helminth-derived proteins as immune system regulators: a systematic review of their promise in alleviating colitis
Helminth-derived proteins have immunomodulatory properties, influencing the host’s immune response as an adaptive strategy for helminth survival....
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Prevalence of schistosomiasis and its association with anemia among pregnant women: a systematic review and meta-analysis
BackgroundSchistosomiasis is a highly prevalent parasitic disease that can lead to adverse maternal and perinatal outcomes. To our knowledge, there...
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Association of schistosomiasis and risk of prostate cancer development in residents of Murehwa rural community, Zimbabwe
BackgroundProstatic male genital schistosomiasis and prostate cancer co-existence cases are uncommon however, some studies have indicated that...
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Freshwater snails of biomedical importance in the Niger River Valley: evidence of temporal and spatial patterns in abundance, distribution and infection with Schistosoma spp.
BackgroundSound knowledge of the abundance and distribution of intermediate host snails is key to understanding schistosomiasis transmission and to...
