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Genome editing approaches with CRISPR/Cas9: the association of NOX4 expression in breast cancer patients and effectiveness evaluation of different strategies of CRISPR/Cas9 to knockout Nox4 in cancer cells
BackgroundThe increasing prevalence of cancer detection necessitated practical strategies to deliver highly accurate, beneficial, and dependable...
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[18F]FDG-PET/CT-based risk stratification in women with locally advanced uterine cervical cancer
Background[ 18 F]FDG-PET/CT is used for staging and treatment planning in patients with locally advanced cervical cancer (LACC). We studied if a...
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Mean platelet volume/platelet count ratio in combination with tumor markers in colorectal cancer: a retrospective clinical study
BackgroundMean platelet volume (MPV) is a marker of platelet activation, which is usually negatively correlated with platelet count (PC). The ratio...
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Low-dose interleukin-2 can improve salivary secretion but not lymphocyte infiltration of salivary glands in a murine model of Sjögren’s syndrome
Introduction/aimEffects of low-dose interleukin-2 (IL-2) on the exocrine glandular glands of Sjögren’s syndrome are unknown. The aim of this study...
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Clinical impact of creatine phosphokinase and c-reactive protein as predictors of postgastrectomy complications in patients with gastric cancer
BackgroundPostoperative complications have been linked to the morbidity and mortality of several cancers. However, predicting whether complications...
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CD4+ effector T cells accelerate Alzheimer’s disease in mice
BackgroundAlzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by pathological deposition of misfolded self-protein...
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Interplay of MicroRNAs and Reactive Oxygen Species in Cancer Stem Cells: New Perspective in Cancer Metastasis
Cancer is one disease that has an enormous social and economic impact on a family and individual. Therapeutic regimens haven’t been able to deal with...
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Next-generation sequencing-assisted diagnosis of a case of leprosy misdiagnosed as erythema multiforme
BackgroundLeprosy is a chronic infectious disease caused by Mycobacterium leprae or Mycobacterium lepromatosis that is mainly transmitted through...
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Epstein-Barr virus infection-associated cholangiocarcinoma: a report of one case and the review of literature
The clinical data of a patient with Epstein-barr virus (EBV) associated with cholangiocarcinoma was reported in this paper: a case of a 36-year-old...
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Pathological response and tumor stroma immunogenic features predict long-term survival in non-small cell lung cancer after neoadjuvant chemotherapy
PurposeMajor pathological response (MPR) has become a surrogate endpoint for overall survival (OS) in non-small cell lung cancer (NSCLC) after...
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Extrathymic AIRE-Expressing Cells: A Historical Perspective
Since its discovery, Aire has been the topic of numerous studies in its role as a transcriptional regulator in the thymus where it promotes the...
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Glutamine deficiency promotes recurrence and metastasis in colorectal cancer through enhancing epithelial–mesenchymal transition
BackgroundGlutamine is the most abundant amino acid in the body and plays a vital role in colorectal cancer (CRC) cell metabolism. However, limited...
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Role of ROS-Mediated Epigenetic Alterations in the Development of Solid Tumor
Tumorigenesis is one of the world’s major causes of death. Endogenous and exogenous factors are involved in the production of reactive oxygen species...
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Breast cancer metastasis to brain results in recruitment and activation of microglia through annexin-A1/formyl peptide receptor signaling
BackgroundDespite advancements in therapies, brain metastasis in patients with triple negative subtype of breast cancer remains a therapeutic...
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Canine leishmaniasis in an endemic region, Northeastern Brazil: a comparative study with four groups of animals
Canine leishmaniasis (CanL) is a zoonosis caused by protozoa of the genus Leishmania and remains an important public health concern in tropical...
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Role of ROS-Mediated Epigenetic Alterations in the Development of Solid Tumor
Tumorigenesis is one of the world’s major causes of death. Endogenous and exogenous factors are involved in the production of reactive oxygen species...
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TPN10475 Constrains Effector T Lymphocytes Activation and Attenuates Experimental Autoimmune Encephalomyelitis Pathogenesis by Facilitating TGF-β Signal Transduction
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) mediated by immune cells, in which auto-reactive...
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Age-Related Changes in Primary and Secondary Lymphoid Organs
Bone marrow is a primary lymphoid organ which gives rise to leukocytes and provides maturation of B cells whereas thymus is also a primary lymphoid...
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Tolerogenic Functions of Plasmacytoid Dendritic Cells
Dendritic cells in the steady state circulate throughout the body, home to tissues, sample antigens, migrate to draining lymph nodes through high...
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The relationship between pepsinogen C and gastric carcinogenesis: a transgene and population study
BackgroundPepsinogen C (PGC) is expressed in chief cells, fundic mucous neck cells, and pyloric gland cells of gastric epithelium and also in breast,...
