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Enlarged tumour-draining lymph node with immune-activated profile predict favourable survival in non-metastatic colorectal cancer
BackgroundThe tumour-draining lymph node (TDLN) plays a pivotal role in the suppression of malignant tumour, however, the immunological profile and...
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A prospective study on tumour response assessment methods after neoadjuvant endocrine therapy in early oestrogen receptor-positive breast cancer
BackgroundNeoadjuvant endocrine therapy (NET) in oestrogen receptor-positive (ER+) /HER2-negative (HER2-) breast cancer allows real-time evaluation...
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Circulating tumour cells in gastrointestinal cancers: food for thought?
Gastrointestinal (GI) cancers account for 35% of cancer-related deaths, predominantly due to their ability to spread and generate drug-tolerant...
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DNA damage response inhibitors enhance tumour treating fields (TTFields) potency in glioma stem-like cells
BackgroundHigh-grade gliomas are primary brain cancers with unacceptably low and persistent survival rates of 10–16 months for WHO grade 4 gliomas...
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Tumour-associated macrophages and Schwann cells promote perineural invasion via paracrine loop in pancreatic ductal adenocarcinoma
BackgroundPancreatic ductal adenocarcinoma (PDAC) is frequently accompanied by perineural invasion (PNI), which is associated with excruciating...
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Circulating tumour cell isolation, analysis and clinical application
BackgroundCirculating tumour cells (CTCs) are cancer cells that circulate in the bloodstream after being shed from solid tumours. They can lead to...
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EpiDiP/NanoDiP: a versatile unsupervised machine learning edge computing platform for epigenomic tumour diagnostics
DNA methylation analysis based on supervised machine learning algorithms with static reference data, allowing diagnostic tumour ty** with...
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Resistance to BRAF inhibition explored through single circulating tumour cell molecular profiling in BRAF-mutant non-small-cell lung cancer
BackgroundResistance mechanisms to combination therapy with dabrafenib plus trametinib remain poorly understood in patients with BRAF V600E -mutant...
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Evolving roles of CD38 metabolism in solid tumour microenvironment
Given that plenty of clinical findings and reviews have already explained in detail on the progression of CD38 in multiple myeloma and haematological...
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The heterogeneity of tumour immune microenvironment revealing the CRABP2/CD69 signature discriminates distinct clinical outcomes in breast cancer
BackgroundIt has been acknowledged that the tumour immune microenvironment (TIME) plays a critical role in determining therapeutic responses and...
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Improving head and neck cancer therapies by immunomodulation of the tumour microenvironment
Targeted immunotherapy has improved patient survival in head and neck squamous cell carcinoma (HNSCC), but less than 20% of patients produce a...
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Immune Cell Trafficking in the Lymphatics, Hyaluronan Biology and Tumour Metastasis
As an integral part of the immune system, the lymphatics enable immune surveillance by shepherding the migration of antigen-laden immune cells to...
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SETDB1 tumour suppressor roles in near-haploid mesothelioma involve TP53
BackgroundMutational inactivation of the SETDB1 histone methyltransferase is found in a subset of mesothelioma, particularly in cases with...
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Tumour cells can escape antiproliferative pressure by interferon-β through immunoediting of interferon receptor expression
Type I interferons (IFNs) play a central role not only in innate immunity against viral infection, but also in the antitumour response, e.g....
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AHRR and SFRP2 in primary versus recurrent high-grade serous ovarian carcinoma and their prognostic implication
BackgroundThe aim of this study was to analyse transcriptomic differences between primary and recurrent high-grade serous ovarian carcinoma (HGSOC)...
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Breast cancer patient-derived organoids for the investigation of patient-specific tumour evolution
BackgroundA reliable preclinical model of patient-derived organoids (PDOs) was developed in a case study of a 69-year-old woman diagnosed with breast...
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An intrinsic purine metabolite AICAR blocks lung tumour growth by targeting oncoprotein mucin 1
BackgroundLung cancer cells overexpress mucin 1 (MUC1) and active subunit MUC1-CT. Although a peptide blocks MUC1 signalling, metabolites targeting...
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Capivasertib combines with docetaxel to enhance anti-tumour activity through inhibition of AKT-mediated survival mechanisms in prostate cancer
Background/objectiveTo explore the anti-tumour activity of combining AKT inhibition and docetaxel in PTEN protein null and WT prostate tumours.
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Low blood level of tumour suppressor miR-5193 as a target of immunotherapy to PD-L1 in gastric cancer
BackgroundRecent studies have identified that low levels of some tumour suppressor microRNAs (miRNAs) in the blood contribute to tumour progression...
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Ultrasound-targeted microbubble destruction remodels tumour microenvironment to improve immunotherapeutic effect
Cancer immunotherapy (CIT) has gained increasing attention and made promising progress in recent years, especially immune checkpoint inhibitors such...
