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Noninvasive ultrasound stimulation to treat myocarditis through splenic neuro-immune regulation
BackgroundThe cholinergic anti-inflammatory pathway (CAP) has been widely studied to modulate the immune response. Current stimulating strategies are...
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First Transcriptome Analysis of Hepatoblastoma in Brazil: Unraveling the Pivotal Role of Noncoding RNAs and Metabolic Pathways
Hepatoblastoma stands as the most prevalent liver cancer in the pediatric population. Characterized by a low mutational burden, chromosomal and...
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Epithelial Nlrp10 inflammasome mediates protection against intestinal autoinflammation
Unlike other nucleotide oligomerization domain-like receptors, Nlrp10 lacks a canonical leucine-rich repeat domain, suggesting that it is incapable...
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Molecular Mechanisms of the Sense of Touch: An Overview of Mechanical Transduction and Transmission in Merkel Discs of Whisker Hair Follicles and Some Clinical Perspectives
The Merkel disc is a main type of tactile end organs for sensing gentle touch and is essential for sophisticated sensory tasks including social...
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Ion Channel Pharmacology for Pain Modulation
A large series of different ion channels have been identified and investigated as potential targets for new medicines for the treatment of a variety...
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Modelling skeletal pain harnessing tissue engineering
Bone pain typically occurs immediately following skeletal damage with mechanical distortion or rupture of nociceptive fibres. The pain mechanism is...
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Revelation of Pivotal Genes Pertinent to Alzheimer’s Pathogenesis: A Methodical Evaluation of 32 GEO Datasets
Alzheimer’s disease (AD), a dreadful neurodegenerative disorder that affects cognitive and behavioral function in geriatric populations, is...
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USH2A is a Meissner’s corpuscle protein necessary for normal vibration sensing in mice and humans
Fingertip mechanoreceptors comprise sensory neuron endings together with specialized skin cells that form the end-organ. Exquisitely sensitive,...
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Three-dimensional microenvironment regulates gene expression, function, and tight junction dynamics of iPSC-derived blood–brain barrier microvessels
The blood–brain barrier (BBB) plays a pivotal role in brain health and disease. In the BBB, brain microvascular endothelial cells (BMECs) are...
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Membrane Transporters and Channels in Melanoma
Recent research has revealed that ion channels and transporters can be important players in tumor development, progression, and therapy resistance in...
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When left does not seem right: epigenetic and bioelectric differences between left- and right-sided breast cancer
BackgroundDuring embryogenesis lateral symmetry is broken, giving rise to Left/Right (L/R) breast tissues with distinct identity. L/R-sided breast...
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Molecular Components of Mechanotransduction Machinery
After decades of intense investigation, the molecular components of mammalian hair-cell mechanotransduction (MET) machinery have started to emerge....
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The contemporary model of vertebral column joint dysfunction and impact of high-velocity, low-amplitude controlled vertebral thrusts on neuromuscular function
PurposeThere is growing evidence that vertebral column function and dysfunction play a vital role in neuromuscular control. This invited review...
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It takes more than two to tango: mechanosignaling of the endothelial surface
The endothelial surface is a highly flexible signaling hub which is able to sense the hemodynamic forces of the streaming blood. The subsequent...
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Linkage analysis revealed risk loci on 6p21 and 18p11.2-q11.2 in familial colon and rectal cancer, respectively
Colorectal cancer (CRC) is one of the major cancer types in the western world including Sweden. However, known genetic risk factors could only...
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The Emerging Pro-Algesic Profile of Transient Receptor Potential Vanilloid Type 4
Transient receptor potential vanilloid type 4 (TRPV4) channels are Ca2+-permeable non-selective cation channels which mediate a wide range of...
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Functional subgroups of rat and human sensory neurons: a systematic review of electrophysiological properties
Sensory neurons are responsible for the generation and transmission of nociceptive signals from the periphery to the central nervous system. They...
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Mechanical regulation of chromatin and transcription
Cells and tissues generate and are exposed to various mechanical forces that act across a range of scales, from tissues to cells to organelles....
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A genetic-phenotypic classification for syndromic micrognathia
Micrognathia is a common craniofacial deformity which represents hypoplastic development of the mandible, accompanied by retrognathia and consequent...
