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Genetically Engineered Large Animals in Biomedicine
Major progress in genetic engineering and genome editing of livestock species has extended their use to biomedical applications, the most notable... -
Pig BVDV-2 non-structural protein (Npro) links to cellular antiviral response in vitro
In this study, we constructed for the first time a full-length cDNA clone of pig-original bovine viral diarrhea virus 2 (BVDV-2) strain SH-28,...
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Complete nucleotide sequence of a subviral DNA molecule of porcine circovirus type 2
Porcine circovirus type 2 (PCV2) is a member of the genus Circovirus in the family Circoviridae . Most subgenomic molecules of PCV2 have been mapped....
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Differential gene expression in porcine SK6 cells infected with wild-type and SAP domain-mutant foot-and-mouth disease virus
Foot-and-mouth disease virus (FMDV) is the causative agent of a highly contagious disease in livestock. The viral proteinase L pro of FMDV is involved...
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Dynein light chain DYNLL1 subunit facilitates porcine circovirus type 2 intracellular transports along microtubules
Microtubule (MT) and dynein motor proteins facilitate intracytoplasmic transport of cellular proteins. Various viruses utilize microtubules and...
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Bio-distribution and Toxicity of Noble Metal Nanoparticles in Humans
Nanotechnology is attracting the interest of scientists since the last few decades and is the technology of twenty-first century. It deals with the... -
MicroRNA-30a-5p promotes replication of porcine circovirus type 2 through enhancing autophagy by targeting 14-3-3
Accumulating evidence demonstrates that autophagy and microRNAs (miRNAs) play key roles in regulating virus-host interactions and can restrict or...
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Porcine circovirus type 2 capsid protein induces unfolded protein response with subsequent activation of apoptosis
Porcine circovirus type 2 (PCV2) has recently been reported to elicit the unfolded protein response (UPR) via activation of the PERK/eIF2α...
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Interactions of porcine circovirus 2 with its hosts
Porcine circovirus 2 (PCV2) can cause porcine circovirus diseases and porcine circovirus-associated diseases (PCVD/PCVAD), which are widely presented...
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Chimeric Pestivirus Experimental Vaccines
Chimeric pestiviruses have shown great potential as marker vaccine candidates against pestiviral infections. Exemplarily, we describe here the... -
Identification and genetic characterization of classical swine fever virus isolates in Brazil: a new subgenotype
The classical swine fever (CSF) is a highly contagious viral disease of pigs and wild boar. The CSF causes great economic losses for pork production...
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Generation of E. coli-derived virus-like particles of porcine circovirus type 2 and their use in an indirect IgG enzyme-linked immunosorbent assay
Porcine circovirus type 2 (PCV2) causes increased mortality and poor growth or weight loss in apparently healthy swine. Therefore, methods to detect...
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Differential sensitivity of porcine endogenous retrovirus to APOBEC3-mediated inhibition
Pigs are considered to be suitable xenotransplantation organ donors. However, the risk of pathogen transmission from pigs to humans is a major...
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Transplant genetics and genomics
Ever since the discovery of the major histocompatibility complex, scientific and clinical understanding in the field of transplantation has been...
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Genome editing revolutionize the creation of genetically modified pigs for modeling human diseases
Pigs have anatomical, physiological and genomic characteristics that make them highly suitable for modeling human diseases. Genetically modified (GM)...
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A glance at subgenomic flavivirus RNAs and microRNAs in flavivirus infections
The family Flaviviridae comprises a wide variety of viruses that are distributed worldwide, some of which are associated with high rates of morbidity...
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Functional characterization of a new promoter isolated from torque teno sus virus 1
Torque teno sus virus 1 (TTSuV1) has a non-enveloped, single-stranded, negative-sense circular DNA genome, and it is widely distributed in pigs. Open...
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Japanese encephalitis virus infects porcine kidney epithelial PK15 cells via clathrin- and cholesterol-dependent endocytosis
BackgroundJapanese encephalitis virus (JEV) is a mosquito-borne flavivirus that causes acute viral encephalitis in humans. Pigs are important...
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Porcine complement regulatory protein CD46 and heparan sulfates are the major factors for classical swine fever virus attachment in vitro
Classical swine fever virus (CSFV) is the causative agent of a severe multi-systemic disease of pigs. While several aspects of virus-host-interaction...
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Classical swine fever virus marker vaccine strain CP7_E2alf: genetic stability in vitro and in vivo
Recently, CP7_E2alf (Suvaxyn ® CSF Marker), a live marker vaccine against classical swine fever virus, was licensed through the European Medicines...