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Regulation of metastatic potential by drug repurposing and mitochondrial targeting in colorectal cancer cells
BackgroundIncreased mitochondrial activities contributing to cancer cell proliferation, invasion, and metastasis have been reported in different...
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PGC-1α Inhibits Schwann Cell Dedifferentiation and Delays Peripheral Nerve Degeneration by Targeting PON1
PPARγ coactivator-1 alpha (PGC-1α) is an essential transcription factor co-activator that regulates gene transcription and neural regeneration....
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High-resolution analyses of human sperm dynamic methylome reveal thousands of novel age-related epigenetic alterations
BackgroundChildren of aged fathers are at a higher risk of develo** mental disorders. Alterations in sperm DNA methylation have been implicated as...
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Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1Alpha (PGC-1α): A Transcriptional Regulator at the Interface of Aging and Age-Related Macular Degeneration?
Human age-related macular degeneration (AMD) is a prevalent age-related disease which causes retinal dysfunction and disability. Genetic and cell...
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Targeting CAR T Cells’ Metabolic Pathways to Boost Their Effectiveness Against Tumors
Chimeric antigen receptor (CAR) T cells have shown decent therapeutic efficacy in treating hematologic cancers; however, their effectiveness has been...
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Differential Expression of PGC1α in Intratumor Redox Subpopulations of Breast Cancer
Our previous studies indicate that the mitochondrial redox state and its intratumor heterogeneity are associated with invasiveness and metastatic...
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Altered H3K4me3 profile at the TFAM promoter causes mitochondrial alterations in preadipocytes from first-degree relatives of type 2 diabetics
BackgroundFirst-degree relatives of type 2 diabetics (FDR) exhibit a high risk of develo** type 2 diabetes (T2D) and feature subcutaneous adipocyte...
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Investigating the Potential Therapeutic Mechanisms of Puerarin in Neurological Diseases
Plants and their derived phytochemicals have a long history of treating a wide range of illnesses for several decades. They are believed to be the...
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Metabolism of Vascular Smooth Muscle
Metabolism refers to chemical reactions that take place in an organism to maintain its structure and activities, to respond to environment changes,...
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( −)-Epicatechin and cardiometabolic risk factors: a focus on potential mechanisms of action
This review summarizes experimental evidence on the beneficial effects of ( −)-epicatechin (EC) attenuating major cardiometabolic risk factors, i.e.,...
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mTOR Signaling: The Interface Linking Cellular Metabolism and Hepatitis B Virus Replication
Mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that includes mTOR complex (mTORC) 1 and mTORC2. The mTOR pathway is activated in...
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Recent Advances in Molecular Pathways and Therapeutic Implications Targeting Mitochondrial Dysfunction for Alzheimer’s Disease
Alzheimer’s disease (AD) is a neurodegenerative disorder which leads to mental deterioration due to aberrant accretion of misfolded proteins in the...
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Dihydromyricetin ameliorates hepatic steatosis and insulin resistance via AMPK/PGC-1α and PPARα-mediated autophagy pathway
BackgroundDihydromyricetin (DHM), a flavonoid compound of natural origin, has been identified in high concentrations in ampelopsis grossedentata and...
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Bisphenol-A Mediated Impaired DRP1-GFER Axis and Cognition Restored by PGC-1α Upregulation Through Nicotinamide in the Rat Brain Hippocampus
The regulatory network of mitochondrial biogenesis and dynamics is vital for mitochondrial functions and cellular homeostasis. Any impairment in the...
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Silencing of hypothalamic FGF11 prevents diet-induced obesity
Fibroblast growth factor 11 (FGF11) is a member of the intracellular fibroblast growth factor family. Here, we report the central role of FGF11 in...
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PTEN-induced kinase 1 deficiency alters albumin permeability and insulin signaling in podocytes
Alterations of insulin signaling in diabetes are associated with podocyte injury, proteinuria, and renal failure. Insulin stimulates glucose...
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Emerin deficiency does not exacerbate cardiomyopathy in a murine model of Emery–Dreifuss muscular dystrophy caused by an LMNA gene mutation
Emery–Dreifuss muscular dystrophy (EDMD), caused by mutations in genes encoding nuclear envelope proteins, is clinically characterized by muscular...
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Upregulation of HMGB1 in tumor-associated macrophages induced by tumor cell-derived lactate further promotes colorectal cancer progression
BackgroundLactate accumulation leads to an acidic tumor microenvironment (TME), in turn promoting colorectal cancer (CRC) progression....
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The genetics of human performance
Human physiology is likely to have been selected for endurance physical activity. However, modern humans have become largely sedentary, with physical...
