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Methylation-mediated silencing of protein kinase C zeta induces apoptosis avoidance through ATM/CHK2 inactivation in dedifferentiated chondrosarcoma
BackgroundDedifferentiated chondrosarcoma (DDCS) is an aggressive bone tumour with a poor prognosis and no effective treatment. Because changes in...
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MYC protein interactors in gene transcription and cancer
The transcription factor and oncoprotein MYC is a potent driver of many human cancers and can regulate numerous biological activities that contribute...
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Transcriptomic landscape based on annotated clinical features reveals PLPP2 involvement in lipid raft-mediated proliferation signature of early-stage lung adenocarcinoma
BackgroundImage-based screening improves the detection of early-stage lung adenocarcinoma (LUAD)but also highlights the issue of high false-positive...
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The intratumour microbiota and neutrophilic inflammation in squamous cell vulvar carcinoma microenvironment
BackgroundA causal link between microbiota composition (dysbiosis) and oncogenesis has been demonstrated for several types of cancer. Neutrophils...
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Telocytes in the Tumor Microenvironment
There are several theories explaining the communication between cells in the context of tumor development. Over the years, interactions between...
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Plant-derived exosome-like nanoparticles for microRNA delivery in cancer treatment
Plant-derived exosome-like nanoparticles (PELNs) are natural nanocarriers and effective delivery systems for plant microRNAs (miRNAs). These...
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Evidence for a causal role by human papillomaviruses in prostate cancer – a systematic review
It is hypothesised that high risk for cancer human papillomaviruses (HPVs) have a causal role in prostate cancer.
In 26 case control studies, high...
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Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries
Colorectal cancer (CRC) is a leading cause of mortality worldwide. We conducted a genome-wide association study meta-analysis of 100,204 CRC cases...
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Extrachromosomal DNA amplifications in cancer
Extrachromosomal DNA (ecDNA) amplification is an important driver alteration in cancer. It has been observed in most cancer types and is associated...
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Translational Reprogramming of mRNA in Oxidative Stress and Cancer
Oxidative distress is a hallmark of cancer. Neoplastic cells produce elevated levels of reactive oxygen species that trigger signaling pathways and...
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Analysis of the Frequency of 10 Polymorphic Markers of CDKN2A and RB1 Genes in Russian Populations
The study of population frequencies of rare clinically significant alleles is a prerequisite of the development of personalized medicine. We...
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A truncated and catalytically inactive isoform of KDM5B histone demethylase accumulates in breast cancer cells and regulates H3K4 tri-methylation and gene expression
KDM5B histone demethylase is overexpressed in many cancers and plays an ambivalent role in oncogenesis, depending on the specific context. This...
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Pemigatinib in previously treated solid tumors with activating FGFR1–FGFR3 alterations: phase 2 FIGHT-207 basket trial
Fibroblast growth factor receptor ( FGFR ) alterations drive oncogenesis in multiple tumor types. Here we studied pemigatinib, a selective, potent,...
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Translational Reprogramming of mRNA in Oxidative Stress and Cancer
Oxidative distress is a hallmark of cancer. Neoplastic cells produce elevated levels of reactive oxygen species that trigger signaling...
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Clinical and Immunological Significance of ANKRD52 in Pan-Cancer
Ankyrin repeat domain 52 (ANKRD52) is a regulatory component of the protein phosphatase 6 (PP6) holoenzyme. Evidence has emerged to suggest...
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Co-occurrence of thyroid and breast cancer is associated with an increased oncogenic SNP burden
BackgroundEpidemiological evidence suggests that synchronous or metachronous presentation of breast and thyroid cancers exceeds that predicted by...
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circCYP24A1 promotes Docetaxel resistance in prostate Cancer by Upregulating ALDH1A3
BackgroundDocetaxel (DTX) is the most widely prescribed first-line chemotherapy for advanced prostate cancer (PCa). Unfortunately, DTX resistance...
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Epi-Drugs Targeting RNA Dynamics in Cancer
From the early discovery of ribonucleic acid in 1868, the RNA world has seen constant evolution. To date, more than ten types of RNA species are...
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Recent advances in the developmental origin of neuroblastoma: an overview
Neuroblastoma (NB) is a pediatric tumor that originates from neural crest-derived cells undergoing a defective differentiation due to genomic and...
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Aging and cancer
Aging and cancer exhibit apparent links that we will examine in this review. The null hypothesis that aging and cancer coincide because both are...
