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MicroRNAs in Neurodegenerative Diseases
MicroRNAs (miRNAs) represent the first and most prominent group of abundant small non-coding RNA molecules discovered to interfere with gene...
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Exosomes: A Cellular Communication Medium That Has Multiple Effects On Brain Diseases
Exosomes, as membranous vesicles generated by multiple cell types and secreted to extracellular space, play a crucial role in a range of brain...
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Investigation of Relationship Between Small Noncoding RNA (sncRNA) Expression Levels and Serum Iron, Copper, and Zinc Levels in Clinical Diagnosed Multiple Sclerosis Patients
In our study, we aimed to investigate the relationship between microRNA (miRNA) expression levels and serum iron (Fe), copper (Cu), and zinc (Zn)...
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Identification of Potential Biomarkers in the Peripheral Blood Mononuclear Cells of Relapsing–Remitting Multiple Sclerosis Patients
Multiple sclerosis (MS) is described as an immune disorder with inflammation and neurodegeneration. Relapsing–remitting MS (RRMS) is one of the most...
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Phenome-wide association study on miRNA-related sequence variants: the UK Biobank
BackgroundGenetic variants in the coding region could directly affect the structure and expression levels of genes and proteins. However, the...
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MicroRNAs in atrial fibrillation target genes in structural remodelling
We aim to elucidate how miRNAs regulate the mRNA signature of atrial fibrillation (AF), to gain mechanistic insight and identify candidate targets...
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“MIRAI” Healthcare: “Future” in Japanese
Combining artificial intelligence (AI) and microRNA (miRNA) can provide precious medical devices. The Human Genome Project determined the complete...
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MicroRNAs as Tools for Early Diagnosis and Predicting Responses to Therapy in Oesophageal Cancer
Oesophageal cancer (EC) is an aggressive and invasive cancer with limited diagnosis and survival. EC usually occurs as either oesophageal...
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MicroRNAs in Cancer: Diagnostics and Therapeutics
Tumor initiation, recurrence, progression, and spread of cancer are multistep processes which involve numerous molecular and cellular mechanisms. One...
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Dysregulation of MicroRNAs Derived from Plasma Extracellular Vesicles in Schizoaffective Disorder
The association between peripheral blood extracellular vesicles (EVs)–derived miRNAs (EVs-miRNAs) and neuropsychiatric diseases has been extensively...
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Resveratrol, curcumin, paclitaxel and miRNAs mediated regulation of PI3K/Akt/mTOR pathway: go four better to treat bladder cancer
Bladder cancer (BC) is a leading cause of death among urothelial malignancies that more commonly affect male population. Poor prognosis and...
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Nanocarrier-Mediated Delivery of MicroRNAs for Fibrotic Diseases
MicroRNAs (miRNAs) are endogenous noncoding RNAs that mediate the fibrotic process by regulating multiple targets. MicroRNA-based therapy can restore...
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Small RNA sequencing of extracellular vesicles identifies circulating miRNAs related to inflammation and oxidative stress in HIV patients
BackgroundExtracellular vesicles (EVs) are nano-sized particles secreted by most cells. EVs carry nucleic acids that hold promise as potential...
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Global survey of miRNAs and tRNA-derived small RNAs from the human parasitic protist Trichomonas vaginalis
BackgroundSmall non-coding RNAs play critical regulatory roles in post-transcription. However, their characteristics in Trichomonas vaginalis , the...
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Establishment of the Diagnostic Signature of Ferroptosis Genes in Multiple Sclerosis
Ferroptosis is a novel form of membrane-dependent cell death that differs from other cell death modalities such as necrosis, apoptosis, and...
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RNA Controls RNA
We know that microRNAs (miRNAs) are ubiquitous in all organisms. On the contrary, proteins are encoded in DNA on the genome and transcribed into...
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Transcriptome analysis reveals lung-specific miRNAs associated with impaired mucociliary clearance induced by cigarette smoke in an in vitro human airway tissue model
Exposure to cigarette smoke (CS) is strongly associated with impaired mucociliary clearance (MCC), which has been implicated in the pathogenesis of...
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Targets identified from exercised heart: killing multiple birds with one stone
Cardiovascular diseases (CVDs) are a major cause of mortality worldwide, which are mainly driven by factors such as aging, sedentary lifestyle, and...
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Identification and validation of methylated differentially expressed miRNAs and immune infiltrate profile in EBV-associated gastric cancer
BackgroundThe recent discovery of cancer/tissue specificity of miRNA has indicated its great potential as a therapeutic target. In Epstein–Barr...
