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Electrical and Morphological Properties of Develo** Motoneurons in Postnatal Mice and Early Abnormalities in SOD1 Transgenic Mice
In this chapter, we review electrical and morphological properties of lumbar motoneurons during postnatal development in wild-type (WT) and...
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Timescales of learning in prefrontal cortex
The lateral prefrontal cortex (PFC) in humans and other primates is critical for immediate, goal-directed behaviour and working memory, which are...
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Why so slow? Models of parkinsonian bradykinesia
Bradykinesia, or slowness of movement, is a defining feature of Parkinson disease (PD) and a major contributor to the negative effects on quality of...
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Motor Neuron Disease: Amyotrophic Lateral Sclerosis
In this chapter, we will review the epidemiology, clinical phenotype, genetics, causes, and management of amyotrophic lateral sclerosis (ALS). ALS is...
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Differences in Neuromuscular Responses During Isometric Muscle Actions Before and After Pubescence
PurposeThe purpose of this study was to examine the responses of electromyographic (EMG) and mechanomyographic (MMG) amplitude across the torque...
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Quantitative electrodiagnostic patterns of damage and recovery after spinal cord injury: a pilot study
Study designProspective observational pilot study.
ObjectivesTo compare quantitative electromyographic (EMG), imaging and strength data at two time...
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Neural Sequences and the Encoding of Time
Converging experimental and computational evidence indicate that on the scale of seconds the brain encodes time through changing patterns of neural...
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Motor imagery while viewing self-finger movements facilitates the excitability of spinal motor neurons
Action observation (AO) and motor imagery (MI) are potential methods to improve various motor functions. AO and MI facilitate corticospinal...
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Altered parabrachial nucleus nociceptive processing may underlie central pain in Parkinson’s disease
The presence of central neuropathic pain in Parkinson’s disease suggests that the brain circuits that allow us to process pain could be dysfunctional...
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Bayesian prediction of psychophysical detection responses from spike activity in the rat sensorimotor cortex
Decoding of sensorimotor information is essential for brain-computer interfaces (BCIs) as well as in normal functioning organisms. In this study,...
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Single channel surface electromyogram deconvolution to explore motor unit discharges
Interference surface electromyogram (EMG) reflects many bioelectric properties of active motor units (MU), which are however difficult to estimate...
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Multimodal neural recordings with Neuro-FITM uncover diverse patterns of cortical–hippocampal interactions
Many cognitive processes require communication between the neocortex and the hippocampus. However, coordination between large-scale cortical dynamics...
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Reduction and recovery of self-sustained muscle activity after fatiguing plantar flexor contractions
PurposePersistent inward calcium and sodium currents (PICs) are crucial for initiation and maintenance of motoneuron firing, and thus muscular force....
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A computational neural model that incorporates both intrinsic dynamics and sensory feedback in the Aplysia feeding network
Studying the nervous system underlying animal motor control can shed light on how animals can adapt flexibly to a changing environment. We focus on...
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Characteristics of motor unit recruitment in boys and men at maximal and submaximal force levels
The aim of this study was to compare voluntary activation (VA) and motor units (MU) recruitment patterns between boys and men at different...
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Multistability in neural systems with random cross-connections
Neural circuits with multiple discrete attractor states could support a variety of cognitive tasks according to both empirical data and model...
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Abstract deliberation by visuomotor neurons in prefrontal cortex
During visually guided behavior, the prefrontal cortex plays a pivotal role in map** sensory inputs onto appropriate motor plans. When the sensory...
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Electrophysiological Studies Support Utility of Positive Modulators of SK Channels for the Treatment of Spinocerebellar Ataxia Type 2
Spinocerebellar ataxia type 2 (SCA2) is an incurable hereditary disorder accompanied by cerebellar degeneration following ataxic symptoms. The...
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A low-power stretchable neuromorphic nerve with proprioceptive feedback
By relaying neural signals from the motor cortex to muscles, devices for neurorehabilitation can enhance the movement of limbs in which nerves have...
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Recruitment of Motoneurons
Beginning about half a century ago, the rules that determine how motor units are recruited during movement have been deduced. These classical...