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SABR-Dual: a phase II/III trial of two-fraction versus five-fraction stereotactic radiotherapy for localized low- and favorable intermediate-risk prostate cancer
BackgroundDose-escalated radiotherapy is known to improve progression free survival in patients with localized prostate cancer, and recent advances...
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Hippocampal subfield vulnerability to α-synuclein pathology precedes neurodegeneration and cognitive dysfunction
Cognitive dysfunction is a salient feature of Parkinson’s disease (PD) and Dementia with Lewy bodies (DLB). The onset of dementia reflects the spread...
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Genetic, maternal, and environmental influences on sociality in a pedigreed primate population
Various aspects of sociality in mammals (e.g., dyadic connectedness) are linked with measures of biological fitness (e.g., longevity). How within-...
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Redefining the Role of Medical Affairs Professionals as Innovators and Leaders in Industry-Led Medical Education
Medical affairs professionals are pivotal players at the intersection of medical innovation and practice in the pharmaceutical industry. They are...
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Acceptability of prehabilitation for cancer surgery: a multi-perspective qualitative investigation of patient and ‘clinician’ experiences
Background‘Prehabilitation’ interventions aim to enhance individuals’ physical fitness prior to cancer treatment, typically involve exercise training...
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History of Rabies in the United States
The history of rabies in the United States is intricately associated with the peoples who settled the land and their knowledge and beliefs about the...
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Welcome to the 2024 ACMT Annual Scientific Meeting
Two hundred sixteen abstracts were selected for presentation at the 2024 American College of Medical Toxicology (ACMT) Annual Scientific Meeting on...
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An alternative approach of TUNEL assay to specifically characterize DNA fragmentation in cell model systems
DNA damage is one of the most important effects induced by chemical agents. We report a comparative analysis of DNA fragmentation on three different...
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Impact of a prehabilitation and recovery programme on emotional well-being in individuals undergoing cancer surgery: a multi-perspective qualitative study
BackgroundPrehabilitation and recovery programmes aim to optimise patients’ physical fitness and mental well-being before, during and after cancer...
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Mistakes strengthen the temporal binding effect in the context of goal-directed actions
Temporal binding is an illusion in which the temporal interval between two events appears compressed. In the context of intentional actions, this...
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LED therapy plus idebenone treatment targeting calcium and mitochondrial signaling pathways in dystrophic muscle cells
Intracellular calcium dysregulation, oxidative stress, and mitochondrial dysfunction are some of the main pathway contributors towards disease...
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Inhibition of intentional binding by an additional sound presentation
When a voluntary action is followed by an effect after a short delay, the time distance between the action and its effect is perceived to be shorter...
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Pathological, morphological, and molecular characterization of the infection by Brachycladium goliath in humpback whale Megaptera novaeangliae
The humpback whale ( Megaptera novaeangliae ) is a cosmopolitan migratory, seasonal mysticete that frequents the Brazilian coast. Strands of specimens...
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Modeling Orthopedic Injury and Its Impact: Biological Measures of Hypercoagulability and their Applications
Post-injury hypercoagulability is commonly seen in injured patients and is associated with an elevated risk of thromboembolic complications,...
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Viscoelastic Hemostatic Assays in the Management of the Trauma Patient
Viscoelastic hemostatic assays (VHAs) have been proposed as an alternative strategy for coagulopathy monitoring, transfusion, and resuscitation...
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Viscoelastic Hemostatic Assays in the Management of the Trauma Patient
Viscoelastic hemostatic assays (VHAs) have been proposed as an alternative strategy for coagulopathy monitoring, transfusion, and resuscitation...
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Molecular Mechanisms of Epilepsy: The Role of the Chloride Transporter KCC2
Epilepsy is a neurological disease characterized by abnormal or synchronous brain activity causing seizures, which may produce convulsions, minor...
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The inflammatory pathology of dysferlinopathy is distinct from calpainopathy, Becker muscular dystrophy, and inflammatory myopathies
The descriptions of muscle pathology in dysferlinopathy patients have classically included an inflammatory infiltrate that can mimic inflammatory...
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