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DAMP sensing and sterile inflammation: intracellular, intercellular and inter-organ pathways
Damage-associated molecular patterns (DAMPs) are endogenous molecules that are released from host cells as a result of cell death or damage. The...
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Eccentric exercise 24 h prior to hypobaric decompression increases decompression strain
PurposeAnimal studies have shown that recent musculoskeletal injuries increase the risk of decompression sickness (DCS). However, to date no similar...
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The New Era of Cancer Cytogenetics and Cytogenomics
The promises of the cancer genome sequencing project, combined with various -omics technologies, have raised questions about the importance of cancer...
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Lack of in vivo mutagenicity of carbendazim in the liver and glandular stomach of MutaMice
BackgroundCarbendazim (methyl 2-benzimidazolecarbamate, CASRN: 10605-21-7) exhibits spindle poisoning effects and is widely used as a fungicide. With...
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Second messenger 2'3'-cyclic GMP-AMP (2'3'-cGAMP): the cell autonomous and non-autonomous roles in cancer progression
Cytosolic double-stranded DNA (dsDNA) is frequently accumulated in cancer cells due to chromosomal instability or exogenous stimulation. Cyclic...
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Identification of disease-related aberrantly spliced transcripts in myeloma and strategies to target these alterations by RNA-based therapeutics
Novel drug discoveries have shifted the treatment paradigms of most hematological malignancies, including multiple myeloma (MM). However, this plasma...
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Mechanism and therapeutic potential of targeting cGAS-STING signaling in neurological disorders
DNA sensing is a pivotal component of the innate immune system that is responsible for detecting mislocalized DNA and triggering downstream...
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Role of the cGAS-STING pathway in radiotherapy for non-small cell lung cancer
One of the most important therapeutic interventions for non-small cell lung cancer is radiotherapy. Ionizing radiation (IR) is classified by...
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Buccal Micronucleus Cytome Assay for the Evaluation of Cytogenetic Status of Healthcare Professionals Contacting with Anti-Cancer Drugs
AbstractHealthcare professionals of chemotherapy departments are in a regular contact with anticancer drugs that have genotoxic properties. The...
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Testing of Medical Devices
Medical device testing plays a vital role in ensuring the safety, efficacy, and quality of medical devices before they are introduced to the market....
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Genotoxicity of Psychotropic Drugs in Experimental and Clinical Studies
Data from studies of the genotoxic activity of psychotropic drugs published over the past 25 years were analyzed. Information describing the...
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High-content imaging analyses of γH2AX-foci and micronuclei in TK6 cells elucidated genotoxicity of chemicals and their clastogenic/aneugenic mode of action
BackgroundThe in vitro micronucleus (MN) test is an important component of a genotoxicity test battery that evaluates chemicals. Although the...
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The regulation of cGAS-STING signaling by RNA virus-derived components
The Cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) serves as a key innate immune signaling axis involved in the regulation of...
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Impact of Nuclear Envelope Stress on Physiological and Pathological Processes in Central Nervous System
The nuclear envelope (NE) separates genomic DNA from the cytoplasm and provides the molecular platforms for nucleocytoplasmic transport, higher-order...
