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MiRNA/mRNA network topology in hepatitis virus B-related liver cirrhosis reveals miR-20a-5p/340-5p as hubs initiating fibrosis
BackgroundThe pathophysiology of hepatitis B-related liver cirrhosis (HBV-LC) remains unclear. This study aimed to explore the disease mechanisms...
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A Panel of miRNA Biomarkers Common to Serum and Brain-Derived Extracellular Vesicles Identified in Mouse Model of Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron disease characterised by the deposition of aggregated proteins including TAR...
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Fatiguing freestyle swimming modifies miRNA profiles of circulating extracellular vesicles in athletes
Extracellular vesicles (EVs) are secreted by various tissues and cells under normal physiological or pathological conditions. Exercise-induced EVs...
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miRNA dysregulation in traumatic brain injury and epilepsy: a systematic review to identify putative biomarkers for post-traumatic epilepsy
Traumatic brain injury (TBI) leads to post-traumatic epilepsy (PTE); hence, both TBI and PTE share various similar molecular mechanisms. MicroRNA...
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miRNA Therapy in Laboratory Models of Acute Spinal Cord Injury in Rodents: A Meta-analysis
miRNA therapy is popularly investigated in treating acute spinal cord injury (SCI) and offers a significant prospect for the treatment of acute SCI....
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Preliminary study using a small plasma extracellular vesicle miRNA panel as a potential biomarker for early diagnosis and prognosis in laryngeal cancer
PurposePlasma extracellular vesicle (EV) miRNAs are important biomarkers for body fluid biopsy. The purpose of this study was to screen and construct...
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Identification of Metabolic Syndrome-Related miRNA–mRNA Regulatory Networks and Key Genes Based on Bioinformatics Analysis
Metabolic syndrome, which affects approximately one-quarter of the world’s population, is a combination of multiple traits and is associated with...
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The various role of microRNAs in breast cancer angiogenesis, with a special focus on novel miRNA-based delivery strategies
After skin malignancy, breast cancer is the most widely recognized cancer detected in women in the United States. Breast cancer (BCa) can happen in...
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Thyroid Cancer: Quantum MicroRNA Language/Artificial Intelligence (MIRAI)-Based Etiologic Analysis of Thyroid Cancer by Serum/Plasma miRNA Panel Data
We have previously demonstrated that cancer pathogenesis can be simulated in silico by using a panel of circulating microRNAs (miRNAs) as biomarkers....
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L-Carnitine augments probenecid anti-inflammatory effect in monoiodoacetate-induced knee osteoarthritis in rats: involvement of miRNA-373/P2X7/NLRP3/NF-κB milieu
Osteoarthritis (OA) is a degenerative joint disease, whereas the underlying molecular trails involved in its pathogenesis are not fully elucidated....
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Exploratory integrated analysis of circulating exosomal miRNA and tissue mRNA related to long-term physical activity for more than 25 years: a bioinformatics study
Physical activity exerts various positive effects on both physical and mental health. Although the comprehensive expression profiles of each microRNA...
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Identification of the miRNA-mRNA regulatory network associated with radiosensitivity in esophageal cancer based on integrative analysis of the TCGA and GEO data
BackgroundThe current study set out to identify the miRNA-mRNA regulatory networks that influence the radiosensitivity in esophageal cancer based on...
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Dysregulation of miRNA-30e-3p targeting IL-1β in an international cohort of systemic autoinflammatory disease patients
AbstractAutoinflammation is the standard mechanism seen in systemic autoinflammatory disease (SAID) patients. This study aimed to investigate the...
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Secretion of miRNA-326-3p by senescent adipose exacerbates myocardial metabolism in diabetic mice
BackgroundAdipose tissue homeostasis is at the heart of many metabolic syndromes such as diabetes. Previously it has been demonstrated that adipose...
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Identification of lncRNA-miRNA-mRNA Networks in the Lenticular Nucleus Region of the Brain Contributes to Hepatolenticular Degeneration Pathogenesis and Therapy
Long non-coding RNAs (lncRNAs) are a recently discovered group of non-coding RNAs that play a crucial role in the regulation of various human...
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Changes in the Expression of miRNA Isoforms and Their Targets in HT-29 Cells after Hypoxic Exposure
Tumor hypoxia is one of the main causes of progression and metastasis of colorectal cancer. Changes in the expression of miRNA responsible for...
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The effect of ellagic acid on sex hormones and miRNA-21 expression in rats with polycystic ovary syndrome
PurposePolycystic ovary syndrome (PCOS) is a common endocrine disorder that affects women of reproductive age. It is characterized by irregular...
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The Role of Cystathionine-β-Synthase, H2S, and miRNA-377 in Hypoxic-Ischemic Encephalopathy: Insights from Human and Animal Studies
We aimed to investigate the mechanism underlying the roles of miRNA-377, Cystathionine-β-synthase (CBS), and hydrogen sulfide (H 2 S) in the...
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Predicting lymph node metastasis and prognosis of individual cancer patients based on miRNA-mediated RNA interactions
BackgroundLymph node metastasis is usually detected based on the images obtained from clinical examinations. Detecting lymph node metastasis from...
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Diagnostic potential of a circulating miRNA model associated with therapeutic effect in heart failure
Heart failure (HF), as the leading cause of death, is continuing to increase along with the aging of the general population all over the world....
