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Metabolic reprogramming by Syntenin-1 directs RA FLS and endothelial cell-mediated inflammation and angiogenesis
A novel rheumatoid arthritis (RA) synovial fluid protein, Syntenin-1, and its receptor, Syndecan-1 (SDC-1), are colocalized on RA synovial tissue...
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Metabolic reprogramming by driver mutation-tumor microenvironment interplay in pancreatic cancer: new therapeutic targets
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers globally with a mortality rate exceeding 95% and very limited therapeutic...
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Crosstalk of organelles in Parkinson’s disease – MiT family transcription factors as central players in signaling pathways connecting mitochondria and lysosomes
Living organisms constantly need to adapt to their surrounding environment and have evolved sophisticated mechanisms to deal with stress....
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Intricate crosstalk between MYB and noncoding RNAs in cancer
MYB is often overexpressed in malignant tumors and plays a carcinogenic role in the initiation and development of cancer. Deletion of the MYB...
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The potential role of omentin-1 in obesity-related metabolic dysfunction-associated steatotic liver disease: evidence from translational studies
BackgroundObesity, characterized by visceral adipose tissue (VAT) expansion, is closely associated with metabolic dysfunction-associated steatotic...
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Inter-Organ Crosstalk in the Development of Obesity-Associated Insulin Resistance
The epidemics of obesity and type 2 diabetes have led to intensive investigation of the underlying mechanisms of these diseases and their main...
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Metabolic Alterations of Hepatocellular Cancer Stem Cells
Hepatocellular carcinoma is the most common type of liver cancer and the third leading cause of cancer-related deaths. Tumour cells exhibit...
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Endurance-dependent urinary extracellular vesicle signature: shape, metabolic miRNAs, and purine content distinguish triathletes from inactive people
Extracellular vesicles (EVs) enriched with bioactive molecules have gained considerable attention in nanotechnology because they are critical to...
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Metabolic reprogramming and epigenetic modifications in cancer: from the impacts and mechanisms to the treatment potential
Metabolic reprogramming and epigenetic modifications are hallmarks of cancer cells. In cancer cells, metabolic pathway activity varies during...
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FASN multi-omic characterization reveals metabolic heterogeneity in pancreatic and prostate adenocarcinoma
BackgroundPancreatic ductal adenocarcinoma (PDAC) and prostate cancer (PCa) are among the most prevalent malignant tumors worldwide. There is now a...
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Exploring sulforaphane as neurotherapeutic: targeting Nrf2-Keap & Nf-Kb pathway crosstalk in ASD
Autism spectrum disorders (ASD) are a family of complex neurodevelopmental disorders, characterized mainly through deficits in social behavior and...
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The hypoxia-driven crosstalk between tumor and tumor-associated macrophages: mechanisms and clinical treatment strategies
Given that hypoxia is a persistent physiological feature of many different solid tumors and a key driver for cancer malignancy, it is thought to be a...
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Intercellular crosstalk between cancer cells and cancer-associated fibroblasts via extracellular vesicles
Intercellular communication plays an important role in cancer initiation and progression through direct contact and indirect interactions, such as...
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Crosstalk of Immuno-Oncology and Metabolism: Influence of Akkermansia muciniphila and Personalized Therapy Approach
A healthy cell can turn into a cancerous cell, which requires a complex mechanism, such as genetic and epigenetic modification. This leads to an...
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Crosstalk Between miRNA and Protein Expression Profiles in Nitrate-Exposed Brain Cells
Growing evidence reported a strong association between the nitrate ingestion and adverse health consequences in humans, including its detrimental...
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Human-derived air–liquid interface cultures decipher Alzheimer’s disease–SARS-CoV-2 crosstalk in the olfactory mucosa
BackgroundThe neurological effects of the coronavirus disease of 2019 (COVID-19) raise concerns about potential long-term consequences, such as an...
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Gut-Brain Axis Modulation of Metabolic Disorders: Exploring the Intertwined Neurohumoral Pathways and Therapeutic Prospects
A significant rise in metabolic disorders, frequently brought on by lifestyle choices, is alarming. A wide range of preliminary studies indicates the...
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Nutritional Modulation of Gut Microbiota Alleviates Metabolic and Neurological Disorders
The food we consume is a reservoir of nutrients and bioactive compounds. Adherence to a prudent diet confers nutrition and health. In the light of...
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The crosstalk between ubiquitination and endocrine therapy
AbstractEndocrine therapy (ET), also known as hormone therapy, refers to the treatment of tumors by regulating and changing the endocrine environment...
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Mechanistic and Therapeutic Crosstalk of Lipid Peroxidation in Oxidative Stress and Breast Cancer
Breast cancer is the most frequently diagnosed and leading cancer with the highest morbidity worldwide in women. In the past few decades, researchers...