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A New Method to Analyze Nonvisual-Based Social-Like Interactions in Asocial Cave Fish
Collective behavior is a hallmark of complex animal systems and can be observed from simpler invertebrates to humans. In fish, shoaling or schooling... -
Homeobox genes and the specification of neuronal identity
The enormous diversity of cell types that characterizes any animal nervous system is defined by neuron-type-specific gene batteries that endow cells...
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Event-related potential evidence for tactile orientation processing in the human brain
It is well known that information on stimulus orientation plays an important role in sensory processing. However, the neural mechanisms underlying...
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Oxytocin and Social Isolation: Nonapeptide Regulation of Social Homeostasis
Social isolation imposes physiological and behavioural effects that can have a severe impact on health, but the underlying mechanisms remain poorly... -
Novel compound heterozygous MYO15A splicing variants in autosomal recessive non-syndromic hearing loss
BackgroundHereditary hearing loss is a highly heterogeneous disorder. This study aimed to identify the genetic cause of a Chinese family with...
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Biophysical Changes in Local Onco-Sphere
Although biophysical changes in sha** the cancer ecosystem is important, it is often overlooked. Biophysical changes in the local onco-sphere... -
Lymphovascular Genomics and Proteomics, Clinical Syndromes, and Cancer Metastasis
The number of genetic mutations that cause lymphedema and other diseases of the lymphatic system has significantly grown in recent years. This... -
Common principles for odour coding across vertebrates and invertebrates
The olfactory system is an ideal and tractable system for exploring how the brain transforms sensory inputs into behaviour. The basic tasks of any...
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Diversity and evolution of serotonergic cells in taste buds of elasmobranchs and ancestral actinopterygian fish
A subset of gustatory cells are serotonin immunoreactive (ir) in the mammalian taste bud. In the taste bud of lamprey, elongated gustatory-like cells...
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The Pulmonary Neuroepithelial Body Microenvironment: A Multifunctional Unit in the Airway Epithelium
Among the intrapulmonary myelinated vagal sensory airway receptors, pulmonary neuroepithelial bodies (NEBs) definitely reveal the most complex... -
A Comparative View of Cerebellar Morphology and Diversity in Fishes
Fish represent the most diverse vertebrate class. Through evolutionary time and habitat adaptations, bony and cartilaginous fishes have taken up... -
Primary cilia as dynamic and diverse signalling hubs in development and disease
Primary cilia, antenna-like sensory organelles protruding from the surface of most vertebrate cell types, are essential for regulating signalling...
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Hyper-physiologic mechanical cues, as an osteoarthritis disease-relevant environmental perturbation, cause a critical shift in set points of methylation at transcriptionally active CpG sites in neo-cartilage organoids
BackgroundOsteoarthritis (OA) is a complex, age-related multifactorial degenerative disease of diarthrodial joints marked by impaired mobility, joint...
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Neural Influence on Cancer Invasion and Metastasis
Nerves modulate the surrounding tissue to facilitate nerve repair and regeneration. This fascinating regenerative ability is demonstrated in case of... -
Novel autosomal dominant TMC1 variants linked to hearing loss: insight into protein-lipid interactions
BackgroundTMC1 , which encodes transmembrane channel-like protein 1, forms the mechanoelectrical transduction (MET) channel in auditory hair cells,...
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Tauopathy-associated tau modifications selectively impact neurodegeneration and mitophagy in a novel C. elegans single-copy transgenic model
BackgroundA defining pathological hallmark of the progressive neurodegenerative disorder Alzheimer’s disease (AD) is the accumulation of misfolded...
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COVID-19 and silent hypoxemia in a minimal closed-loop model of the respiratory rhythm generator
Silent hypoxemia, or “happy hypoxia,” is a puzzling phenomenon in which patients who have contracted COVID-19 exhibit very low oxygen saturation (
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Transcriptomic Analysis of the Rat Dorsal Root Ganglion After Fracture
In fractures, pain signals are transmitted from the dorsal root ganglion (DRG) to the brain, and the DRG generates efferent signals to the injured...
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In Vivo Analysis of Hair Cell Sensory Organs in Zebrafish: From Morphology to Function
Hair cells are the sensory receptors of the vertebrate auditory and vestibular systems. In aquatic vertebrates, hair cells are present in the inner...