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Targeting CRAF kinase in anti-cancer therapy: progress and opportunities
The RAS/mitogen-activated protein kinase (MAPK) signaling cascade is commonly dysregulated in human malignancies by processes driven by RAS or RAF ...
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Mitogen-activated protein kinase p38 modulates pacemaker ion channels differentiation in P19-derived pluripotent cells
Signal regulators during early cardiogenetic differentiation for the cellular automaticity are largely unknown. Our investigations were designed to...
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Cytokine regulation of apoptosis-induced apoptosis and apoptosis-induced cell proliferation in vascular smooth muscle cells
Vascular smooth muscle cells (VSMCs) are the main structural cell of blood vessels, and VSMC apoptosis occurs in vascular disease, after injury, and...
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The m6A RNA methylation regulates oncogenic signaling pathways driving cell malignant transformation and carcinogenesis
The m 6 A RNA methylation is the most prevalent internal modification in mammalian mRNAs which plays critical biological roles by regulating vital...
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MAP4K3/GLK in autoimmune disease, cancer and aging
MAP4K3 (also named GLK) is a serine/threonine kinase, which belongs to the mammalian Ste20-like kinase family. At 22 years of age, GLK was initially...
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Molecular pathways, resistance mechanisms and targeted interventions in non-small-cell lung cancer
Lung cancer is the leading cause of cancer-related mortality worldwide. The discovery of tyrosine kinase inhibitors effectively targeting EGFR...
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Transcriptional regulation of memory B cell differentiation
Memory B cells (MBCs) are critical for the rapid development of protective immunity following re-infection. MBCs capable of neutralizing distinct...
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Plant responses to geminivirus infection: guardians of the plant immunity
BackgroundGeminiviruses are circular, single-stranded viruses responsible for enormous crop loss worldwide. Rapid expansion of geminivirus diversity...
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Cellular and molecular mechanisms breaking immune tolerance in inborn errors of immunity
In addition to susceptibility to infections, conventional primary immunodeficiency disorders (PIDs) and inborn errors of immunity (IEI) can cause...
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Antiproliferative effect of bacterial cyclodipeptides in the HeLa line of human cervical cancer reveals multiple protein kinase targeting, including mTORC1/C2 complex inhibition in a TSC1/2-dependent manner
Cervix adenocarcinoma rendered by human papillomavirus (HPV) integration is an aggressive cancer that occurs by dysregulation of multiple pathways,...
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Uev1A promotes breast cancer cell survival and chemoresistance through the AKT-FOXO1-BIM pathway
BackgroundUbiquitin-conjugating enzyme variant UEV1A is required for Ubc13-catalyzed K63-linked poly-ubiquitination that regulates several signaling...
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Testicular Signaling: Team Work in Sperm Production
The male gonads, testis, have two main functions: testosterone production (steroidogenesis), a fundamental hormone for the development and...
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MiR-302a/b/c/d cooperatively sensitizes breast cancer cells to adriamycin via suppressing P-glycoprotein(P-gp) by targeting MAP/ERK kinase kinase 1 (MEKK1)
BackgroundThe importance of individual microRNAs (miRNAs) in tumor has been established in different cancers. However, their association with tumor...
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Sensing microbial infections in the Drosophila melanogaster genetic model organism
Insects occupy a central position in the biosphere. They are able to resist infections even though they lack an adaptive immune system. Drosophila...
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Integrated analysis of the aging brain transcriptome and proteome in tauopathy
BackgroundTau neurofibrillary tangle pathology characterizes Alzheimer’s disease and other neurodegenerative tauopathies. Brain gene expression...
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T-Cell Activation and Differentiation: Role of Signaling and Metabolic Cross-Talk
Different types of T effector cells function centrally in the immune-regulatory network, which acts as a line of defense for the body and elicits...
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Role of Phytochemicals in Modulating Signaling Cascades in Cancer Cells
Dietary and environmental factors have been known to affect human health, for good or for bad. Diet plays a crucial role in modulating the disease...
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Comparative virology of HTLV-1 and HTLV-2
Human T cell leukemia virus type 1 (HTLV-1) was the first discovered human retrovirus and the etiologic agent of adult T-cell leukemia and...
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Sanguinarine inhibits the proliferation of BGC-823 gastric cancer cells via regulating miR-96-5p/miR-29c-3p and the MAPK/JNK signaling pathway
Sanguinarine (SAN), a quaternary benzophenanthridine alkaloid extracted from the root of Papaveraceae plants, has shown antitumour effects in...
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M1 macrophage dependent-p53 regulates the intracellular survival of mycobacteria
Tumor suppressor p53 is not only affects immune responses but also contributes to antibacterial activity. However, its bactericidal function during...
