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WSB1, as an E3 ligase, restrains myocardial ischemia–reperfusion injury by activating β-catenin signaling via promoting GSK3β ubiquitination
BackgroundReperfusion is the most effective strategy for myocardial infarct, but induces additional injury. WD repeat and SOCS box containing protein...
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Prognostic value and biological function of LRRN4 in colorectal cancer
BackgroundSeveral nervous and nerve-related biomarkers have been detected in colorectal cancer (CRC) and can contribute to the progression of CRC....
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Proteomic Profiling Reveals Specific Molecular Hallmarks of the Pig Claustrum
The present study, employing a comparative proteomic approach, analyzes the protein profile of pig claustrum (CLA), putamen (PU), and insula (IN)....
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Leptin Attenuates Fear Memory by Inhibiting Astrocytic NLRP3 Inflammasome in Post-traumatic Stress Disorder Model
Accumulating evidence suggests that the activation of nucleotide-binding domain and leucine-rich repeat protein-3 (NLRP3) inflammasome contributes to...
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Dementia with Lewy bodies in first-generation immigrants in a European memory clinic
We wanted to explore possible differences in disease presentation, frequency, and age of onset of dementia with Lewy bodies (DLB) between...
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The Human LRRK2 Modulates the Age-Dependent Effects of Developmental Methylmercury Exposure in Caenorhabditis elegans
Methylmercury (MeHg) neurotoxicity exhibits age-dependent effects with a latent and/or persistent neurotoxic effect on aged animals. Individual...
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Regulators of proteostasis are translationally repressed in fibroblasts from patients with sporadic and LRRK2-G2019S Parkinson’s disease
Deficits in protein synthesis are associated with Parkinson’s disease (PD). However, it is not known which proteins are affected or if there are...
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The Roles of Cullin-2 E3 Ubiquitin Ligase Complex in Cancer
Posttranslational protein modifications play an important role in regulating protein stability and cellular function. There are at least eight Cullin...
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The SARS-CoV-2 nucleocapsid protein: its role in the viral life cycle, structure and functions, and use as a potential target in the development of vaccines and diagnostics
Coronavirus disease 2019 (COVID-19) continues to take a heavy toll on personal health, healthcare systems, and economies around the globe. Scientists...
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CaMKII: a central molecular organizer of synaptic plasticity, learning and memory
Calcium–calmodulin (CaM)-dependent protein kinase II (CaMKII) is the most abundant protein in excitatory synapses and is central to synaptic...
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ERBB Signaling Pathway in Cancer Stem Cells
The epidermal growth factor receptor (EGFR) was first tyrosine kinase receptor linked to human cancers. EGFR or ERBB1 is a member of ERBB subfamily,...
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Impact of intracellular innate immune receptors on immunometabolism
Immunometabolism, which is the metabolic reprogramming of anaerobic glycolysis, oxidative phosphorylation, and metabolite synthesis upon immune cell...
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Pathophysiology and Management Approaches for Huntington’s Disease, Multiple Sclerosis, and Other Neurological Disorder
Huntington’s disease (HD), multiple sclerosis (MS), and amyotrophic lateral sclerosis (ALS) are neurological disorders. HD is a hereditary...
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LRRK2 is a candidate prognostic biomarker for clear cell renal cell carcinoma
BackgroundClear cell renal cell carcinoma (ccRCC), derived from renal tubular epithelial cells, is the most common malignant tumor of the kidney. The...
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LRRK2 Ablation Attenuates Αlpha-Synuclein–Induced Neuroinflammation Without Affecting Neurodegeneration or Neuropathology In Vivo
The development of disease-modifying therapies for Parkinson’s disease is a major challenge which would be facilitated by a better understanding of...
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Rheumatoid Arthritis Treatment Options and Type 2 Diabetes: Unravelling the Association
Multiple lines of evidence have increasingly suggested a pathogenic connection between rheumatoid arthritis (RA) and the mechanisms of type 2...
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Structural basis of NLR activation and innate immune signalling in plants
Animals and plants have NLRs (nucleotide-binding leucine-rich repeat receptors) that recognize the presence of pathogens and initiate innate immune...
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Emerging targets signaling for inflammation in Parkinson’s disease drug discovery
Parkinson’s disease (PD) patients not only show motor features such as bradykinesia, tremor, and rigidity but also non-motor features such as...
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Origin and evolution of the triploid cultivated banana genome
Most fresh bananas belong to the Cavendish and Gros Michel subgroups. Here, we report chromosome-scale genome assemblies of Cavendish (1.48 Gb) and...
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Is LRRK2 the missing link between inflammatory bowel disease and Parkinson’s disease?
Links that implicate the gastrointestinal system in Parkinson’s disease (PD) pathogenesis and progression have become increasingly common. PD shares...
