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Cost-effectiveness analysis of CYP3A5 genotype-guided tacrolimus dosing in solid organ transplantation using real-world data
The objective of this study was to estimate the cost-effectiveness of CYP3A5 genotype-guided tacrolimus dosing in kidney, liver, heart, and lung...
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Lung Transplantation under a Janus Kinase Inhibitor in Three Patients with SAVI Syndrome
Stimulator of interferon genes (STING)-associated vasculopathy with onset in infancy (SAVI) is a very rare autoinflammatory disease related to STING1 ...
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Humoral immunity to SARS-CoV-2 in kidney transplant recipients and dialysis patients: IgA and IgG patterns unraveled after SARS-CoV-2 infection and vaccination
BackgroundInfection with SARS-CoV-2 in high-risk groups such as kidney transplant and dialysis patients is shown to be associated with a more serious...
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AKI-Pro score for predicting progression to severe acute kidney injury or death in patients with early acute kidney injury after cardiac surgery
BackgroundNo reliable clinical tools exist to predict acute kidney injury (AKI) progression. We aim to explore a scoring system for predicting the...
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Prevotella copri transplantation promotes neurorehabilitation in a mouse model of traumatic brain injury
BackgroundThe gut microbiota plays a critical role in regulating brain function through the microbiome-gut-brain axis (MGBA). Dysbiosis of the gut...
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Diabetic Kidney Disease: From Pathogenesis to Novel Treatment Possibilities
One of the microvascular complications of diabetes is diabetic kidney disease (DKD), often leading to end stage renal disease (ESRD) in which...
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Evaluation of telomeric KIR genes and their association with CMV infection in kidney transplant recipients
Cytomegalovirus (CMV) infection is a common complication after organ transplantation. Despite the immunosuppressed state, natural killer (NK) cells...
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A Population Pharmacokinetic Model of Whole-Blood and Intracellular Tacrolimus in Kidney Transplant Recipients
Background and ObjectiveThe tacrolimus concentration within peripheral blood mononuclear cells may correlate better with clinical outcomes after...
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PIRCHE-II Risk and Acceptable Mismatch Profile Analysis in Solid Organ Transplantation
To optimize outcomes in solid organ transplantation, the HLA genes are regularly compared and matched between the donor and recipient. However, in...
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An Updated Review of Mitochondrial Transplantation as a Potential Therapeutic Strategy Against Cerebral Ischemia and Cerebral Ischemia/Reperfusion Injury
Regardless of the progress made in the pathogenesis of ischemic stroke, it remains a leading cause of adult disability and death. To date, the most...
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The gut microbiome tango in the progression of chronic kidney disease and potential therapeutic strategies
Chronic kidney disease (CKD) affects more than 10% population worldwide and becomes a huge burden to the world. Recent studies have revealed...
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Successful treatment of a kidney transplant patient with COVID-19 and late-onset Pneumocystis jirovecii pneumonia
BackgroundSolid transplant patients are susceptible to Pneumocystis jirovecii pneumonia (PJP). While the vast majority of PJP cases occur within the...
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A meta-analysis of GFR slope as a surrogate endpoint for kidney failure
Glomerular filtration rate (GFR) decline is causally associated with kidney failure and is a candidate surrogate endpoint for clinical trials of...
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Tolerance and Transplantation Immunology
In this chapter, we will first discuss about the impact and mechanisms of immunological tolerance, which is differentiated into central and...
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Th1-dominant cytokine responses in kidney patients after COVID-19 vaccination are associated with poor humoral responses
Cytokines are regulators of the immune response against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). However, the contribution of...
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In Vivo Imaging of Naked and Microencapsulated Islet Cell Transplantation
We describe step-by-step methods to label human pancreatic islet cells and murine insulinoma cells and their subsequent transplantation into type I...
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Anticoagulation with osocimab in patients with kidney failure undergoing hemodialysis: a randomized phase 2 trial
Individuals with kidney failure undergoing hemodialysis are at elevated risk for thromboembolic events. Factor (F) XI, which is in the intrinsic...
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Decreased frequency of Th22 cells and IL-22 cytokine in kidney transplant patients with active cytomegalovirus infection
BackgroundThe immunity of CD4 + T cell subsets against human cytomegalovirus (HCMV) is considerable due to their essential role in controlling the...
