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ROS/PI3K/Akt and Wnt/β-catenin signalings activate HIF-1α-induced metabolic reprogramming to impart 5-fluorouracil resistance in colorectal cancer
BackgroundAcquired resistance of 5-fluorouracil (5-FU) remains a clinical challenge in colorectal cancer (CRC), and efforts to develop targeted...
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Altered Behavioral Performance in the Neuron-Specific HIF-1- and HIF-2-Deficient Mice Following Chronic Hypoxic Exposure
Hypoxia-inducible factors (HIFs) are transcriptional regulators that mediate in mice for HIF-1 and HIF-2. The objective of this study was to...
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Drp1 activates ROS/HIF-1α/EZH2 and triggers mitochondrial fragmentation to deteriorate hypercalcemia-associated neuronal injury in mouse model of chronic kidney disease
BackgroundChronic kidney disease (CKD), characterized as renal dysfunction, is regarded as a major public health problem which carries a high risk of...
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The histone deacetylase SIRT6 promotes glycolysis through the HIF-1α/HK2 signaling axis and induces erlotinib resistance in non-small cell lung cancer
Erlotinib is a first-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI). Overcoming erlotinib resistance is crucial to...
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(H)IF applicable: promotion of neurogenesis by induced HIF-2 signalling after ischaemia
HIF-2 represents a tissue-specific isoform of the hypoxia-inducible factors (HIFs) which regulate oxygen homeostasis in the cell. In acute oxygen...
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Renal hypoxia–HIF–PHD–EPO signaling in transition metal nephrotoxicity: friend or foe?
The kidney is the main organ that senses changes in systemic oxygen tension, but it is also the key detoxification, transit and excretion site of...
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The HIF complex recruits the histone methyltransferase SET1B to activate specific hypoxia-inducible genes
Hypoxia-inducible transcription factors (HIFs) are fundamental to cellular adaptation to low oxygen levels, but it is unclear how they interact with...
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Melatonin, an endogenous hormone, modulates Th17 cells via the reactive-oxygen species/TXNIP/HIF-1α axis to alleviate autoimmune uveitis
BackgroundMelatonin, an indoleamine produced by the pineal gland, plays a pivotal role in maintaining circadian rhythm homeostasis. Recently, the...
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A Novel Mitochondria-Targeting Iron Chelator Neuroprotects Multimodally via HIF-1 Modulation Against a Mitochondrial Toxin in a Dopaminergic Cell Model of Parkinson’s Disease
Coumarins are plant-derived polyphenolic compounds belonging to the benzopyrones family, possessing wide-ranging pharmaceutical applications...
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MicroRNA-449a delays lung cancer development through inhibiting KDM3A/HIF-1α axis
BackgroundIt has been established that microRNA (miR)-449a is anti-tumorigenic in cancers, including lung cancer. Therefore, this study further...
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Lnc-RP11-536 K7.3/SOX2/HIF-1α signaling axis regulates oxaliplatin resistance in patient-derived colorectal cancer organoids
BackgroundResistance to oxaliplatin is a major obstacle for the management of locally advanced and metastatic colon cancer (CC). Although long...
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STAT3/HIF-1α signaling activation mediates peritoneal fibrosis induced by high glucose
BackgroundEpithelial-mesenchymal transition (EMT) of mesothelial cells is a key step in the peritoneal fibrosis (PF). Recent evidence indicates that...
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Claudin-1/4 as directly target gene of HIF-1α can feedback regulating HIF-1α by PI3K-AKT-mTOR and impact the proliferation of esophageal squamous cell though Rho GTPase and p-JNK pathway
Immunohistochemical microarray comprising 80 patients with esophageal squamous cell carcinoma (ESCC) and discovered that the expression of CLDN1 and CLDN4...
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HIF-1α as a Potential Therapeutic Target for Tuberculosis Treatment
Hypoxia-inducible factors (HIFs) represent a family of master regulators that respond to hypoxia in the cellular microenvironment. At the molecular...
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Glioma angiogenesis is boosted by ELK3 activating the HIF-1\(\alpha\)/VEGF-A signaling axis
BackgroundClinical studies have shown that first-line use of anti-angiogenetic therapy can prolong progression-free survival but little progress has...
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PHD2 attenuates high-glucose-induced blood retinal barrier breakdown in human retinal microvascular endothelial cells by regulating the Hif-1α/VEGF pathway
ObjectiveDiabetic macular edema (DME) is one of the most frequent causes of severe vision loss. The pathogenesis of DME is still not fully...
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Pseudoginsengenin DQ exerts antitumour activity against hypopharyngeal cancer cells by targeting the HIF-1α-GLUT1 pathway
BackgroundGinsenosides have been reported to possess a variety of biological activities. Synthesized from the ginsenoside protopanaxadiol (PPD), the...
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HIF-1α switches the functionality of TGF-β signaling via changing the partners of smads to drive glucose metabolic reprogramming in non-small cell lung cancer
BackgroundMost cancer cells have fundamentally different metabolic characteristics, particularly much higher glycolysis rates than normal tissues,...
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Hypoxia enhances ILC3 responses through HIF-1α-dependent mechanism
Group 3 innate lymphoid cells (ILC3) have a prominent role in the maintenance of intestine mucosa homeostasis. The hypoxia-inducible factor (HIF) is...
