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Predictive factors for sepsis by carbapenem resistant Gram-negative bacilli in adult critical patients in Rio de Janeiro: a case-case-control design in a prospective cohort study
BackgroundStudies have investigated risk factors for infections by specific species of carbapenem-resistant Gram-negative bacilli (CR-GNB), but few...
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The plasma proteome differentiates the multisystem inflammatory syndrome in children (MIS-C) from children with SARS-CoV-2 negative sepsis
BackgroundThe Multi-System Inflammatory Syndrome in Children (MIS-C) can develop several weeks after SARS-CoV-2 infection and requires a distinct...
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Interaction with the host: the role of fibronectin and extracellular matrix proteins in the adhesion of Gram-negative bacteria
The capacity of pathogenic microorganisms to adhere to host cells and avoid clearance by the host immune system is the initial and most decisive step...
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The effect of varying multidrug-resistence (MDR) definitions on rates of MDR gram-negative rods
BackgroundA multitude of definitions determining multidrug resistance (MDR) of Gram-negative organisms exist worldwide. The definitions differ...
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In vitro activity of ceftazidime–avibactam and comparators against Gram-negative bacterial isolates collected in the Asia–Pacific region as part of the INFORM program (2015–2017)
BackgroundAntimicrobial resistance among nosocomial Gram-negative pathogens is a cause for concern in the Asia–Pacific region. The aims of this study...
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Incidence and risk factors for mortality in patients treated with combined ceftaroline for Gram-positive infective endocarditis
BackgroundCeftaroline is a fifth-generation cephalosporin and represents an alternative in the treatment of infective endocarditis (IE). The main...
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Successful use of dalbavancin in the treatment of gram positive blood stream infections: a case series
BackgroundDalbavancin is a semisynthetic antibiotic used as an alternative to vancomycin for skin infections and osteomyelitis. Its long half-life...
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Fibulin2: a negative regulator of BMSC osteogenic differentiation in infected bone fracture healing
Bone fracture remains a common occurrence, with a population-weighted incidence of approximately 3.21 per 1000. In addition, approximately 2% to 50%...
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Triple negative breast cancer metastasis is hindered by a peptide antagonist of F11R/JAM‑A protein
BackgroundThe F11R/JAM-A cell adhesion protein was examined as the therapeutic target in triple negative breast cancer (TNBC) with the use of the...
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Treatment pattern, prognostic factors, and outcome in patients with infection due to pan-drug-resistant gram-negative bacteria
The present study investigated the clinical course, treatment pattern, prognostic factors, and outcome of patients with pun-drug resistant (PDR)...
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Rickettsia, Orientia, Ehrlichia and Coxiella
Rickettsiae are obligate, intracellular, very small (0.3 × 1–2 μm), Gram-negative bacilli that multiply within the cytoplasm of eukaryotic cells....
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Antiseptics and mupirocin resistance in clinical, environmental, and colonizing coagulase negative Staphylococcus isolates
BackgroundCoagulase-Negative Staphylococci (CoNS) are opportunistic and nosocomial pathogens. The excessive use of antimicrobial agents, including...
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Comparing ethanol lock therapy versus vancomycin lock in a salvation strategy for totally implantable vascular access device infections due to coagulase-negative staphylococci (the ETHALOCK study): a prospective double-blind randomized clinical trial
ObjectivesLittle is known about efficacy and safety of ethanol lock therapy (ELT) to treat totally implantable venous access device (TIVAD)...
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New Cephalosporins: Fifth and Sixth Generations
New generation (5th) of cephalosporins have been introduced on the market over the last decade to combat methicillin-resistant Staphylococcus aureus...
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Increased Serum Immunoglobulin Responses to Gut Commensal Gram-Negative Bacteria in Unipolar Major Depression and Bipolar Disorder Type 1, Especially When Melancholia Is Present
Major depressive disorder (MDD) is accompanied by higher serum IgM/IgA responses to LPS of Gram-negative bacteria, suggesting increased bacterial...
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Exosomal PPARγ derived from macrophages suppresses LPS-induced peritonitis by negative regulation of CD14/TLR4 axis
BackgroundIntercellular communication between macrophages and peritoneal mesothelial cells (PMCs) has been suggested as a key factor regulating...
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Multidrug-resistant gram-negative organisms and association with 1-year mortality, readmission, and length of stay in Veterans with spinal cord injuries and disorders
Study designRetrospective cohort study.
ObjectivesThe goal of this study was to assess the impact of multidrug resistant gram-negative organisms...
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Standard Microbiological Techniques (Staining, Morphological and Cultural Characteristics, Biochemical Properties, and Seroty**) in the Detection of ESKAPE Pathogens
ESKAPE pathogens are multidrug-resistant bacteria that pose a significant threat to public health. The early and accurate detection of these...
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Oritavancin for the treatment of complicated gram-positive infection in persons who inject drugs
BackgroundTreatment of complicated infections in persons who inject drugs (PWID) and patients experiencing homelessness poses a unique challenge to...
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Flies from a tertiary hospital in Rwanda carry multidrug-resistant Gram-negative pathogens including extended-spectrum beta-lactamase-producing E. coli sequence type 131
Multidrug-resistant gram-negative (MRGN) bacteria are a serious threat to global health. We used genomics to study MRGN obtained from houseflies in a...
