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Proliferation and aneusomy predict survival of young patients with astrocytoma grade II
The clinical course of astrocytoma grade II (AII) is highly variable and not reflected by histological characteristics. As one of the best prognostic...
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Brain tumors and polyomaviruses
Polyomaviruses, including JC virus (JCV), BK virus (BKV), and simian virus 40 (SV40) have attracted much attention in the past decade due to their...
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Cerebral Hemispheres: Neuropathology and Clinical Correlation II. Non-Vascular Syndromes
In the era of the automobile, bicycle, and motorcycle, trauma to the head constitutes one of the most frequent neurologi-cal problems presented to...
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Clinicopathological features, MIB-1 labeling index and apoptotic index in recurrent astrocytic tumors
This is a study of 64 cases of recurrent astrocytic tumors of all four WHO grades wherein a comparative evaluation of initial vs. recurrent tumor was...
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Analysis of p53 mutation and expression in pleomorphic xanthoastrocytoma
Pleomorphic xanthoastrocytoma (PXA) is a rare, superficially situated tumor that most frequently occurs in the temporal lobe of young adults and is...
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Loss of chromosome 10 is an independent prognostic factor in high-grade gliomas
Loss of heterozygosity (LOH) for chromosome 10 is the most frequent genetic abnormality observed in high-grade gliomas. We have used fluorescent...
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A correlative study of gliomas usingIn vivo bromodeoxyuridine labeling index and computer-aided malignancy grading
An in vivo bromodeoxyuridine (BrdU) labeling index (LI) was estimated in 43 cases of astrocytic tumors and mixed gliomas by one hour intra-opera-tive...
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Simultaneous alterations of retinoblastoma and p53 protein expression in astrocytic tumors
The genetic alterations frequently involved in glial malignancies are in the tumor suppressor genes, Rb and p53. An altered Rb expression or p53...
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Mutation in the PTEN/MMAC1 gene in archival low grade and high grade gliomas
The PTEN gene, located on 10q23.3, has recently been described as a candidate tumour suppressor gene that may be important in the development of...
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Current Treatment Modalities for Brain Tumor
Because they are relatively refractory to current treatments, brain tumors are particularly promising candidates for genetic therapy. For many...
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The level of MnSOD is directly correlated with grade of brain tumours of neuroepithelial origin
The oxy-radical scavenger enzyme manganese superoxide dismutase (MnSOD) may act in the capacity of a tumour-suppressor gene. To address the issue of...
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Bone morphogenetic protein type IB receptor is progressively expressed in malignant glioma tumours
The distribution of bone morphogenetic protein (BMP) type I receptors and the activin type I receptor (ActR-I) was investigated in 16 cases of human...
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Synthesis and secretion of α2-macroglobulin by human glioma established cell lines
Human α 2 -macroglobulin (α 2 M) is a high molecular weight plasma proteinase inhibitor exhibiting a broad specificity; in fact it is capable of binding...
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Immunohistochemical localisation of tissue plasminogen activator in human brain tumours
The distribution of tissue plasminogen activator (t-PA) has been studied in a series of 38 human brain tumours and two specimens of cerebral cortex,...
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Glycolipids and gliomas
Several aspects of the relationships between glycolipids, gliomas, and problems involved in studying these are reviewed. Major problems that...
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Serum ceruloplasmin and copper levels in patients with primary brain tumors
Serum copper and ceruloplasmin levels are known to increase in several malignancies such as osteosarcomas, some gastrointestinal tumors, and lung...
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Gangliosides and Related Compounds as Biological Response Modifiers
In the previous chapter1 we already discussed the curious fact that a considerably large number of glycosphingolipids (GSL) occur sporadically in...