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Design and Synthesis of Polymer Prodrugs for Improving Water-Solubility, Pharmacokinetic Behavior and Antitumor Efficacy of TXA9
PurposeTXA9, a novel cardiac glycoside, has a potent anti-proliferative effect against A549 human lung cancer cells, however, possesses a poor...
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Pluronic F68-Linoleic Acid Nano-spheres Mediated Delivery of Gambogic Acid for Cancer Therapy
Gambogic acid (GA), a natural compound from gamboge resin, has been introduced as a promising antitumor drug contributing to its broad spectrum of...
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Neuroprotective Agents
A pharmacological classification of various neuroprotective agents is shown in Table 2.1. Approximately 80 categories are listed and include examples...
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Chitosan-Based Systems for Theranostic Applications
The ideal theranostic approach is capable of several functions ranging from diagnosis to treatment with accurate targeting of cancer-specific cells....
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Axonal and Myelin Neuroprotection by the Peptoid BN201 in Brain Inflammation
The development of neuroprotective therapies is a sought-after goal. By screening combinatorial chemical libraries using in vitro assays, we...
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Tellurium, the Forgotten Element: A Review of the Properties, Processes, and Biomedical Applications of the Bulk and Nanoscale Metalloid
Tellurium (Te) is a brittle, mildly toxic, and rare metalloid with an extremely low abundance in the planet. The element has been used in both its...
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TRAIL-based gene delivery and therapeutic strategies
TRAIL (tumor necrosis factor-related apoptosis-inducing ligand), also known as APO2L, belongs to the tumor necrosis factor family. By binding to the...
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(−)-Epigallocatechin-3-gallate derivatives combined with cisplatin exhibit synergistic inhibitory effects on non-small-cell lung cancer cells
BackgroundNon-small-cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide. The inhibition of epidermal growth factor...
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Quality Control in Huntington’s Disease: a Therapeutic Target
Huntington’s disease (HD) is a fatal autosomal dominantly inherited brain disease caused by excessively expanded CAG repeats in gene which encodes...
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Role of Non Receptor Tyrosine Kinases in Hematological Malignances and its Targeting by Natural Products
Tyrosine kinases belong to a family of enzymes that mediate the movement of the phosphate group to tyrosine residues of target protein, thus...
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Intracellular Delivery: An Overview
Targeted intracellular delivery is gaining importance, especially for improved therapy of cancer and intracellular infections. Endocytosis or...
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Morin protects glucocorticoid-induced osteoporosis through regulating the mitogen-activated protein kinase signaling pathway
Our aim is to investigate the potential therapeutic value of morin against osteoporosis and elucidate the mechanism of action. Osteoporosis was...
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Pro-survival autophagy and cancer cell resistance to therapy
Resistance to therapy is one of the prime causes for treatment failure in cancer and recurrent disease. In recent years, autophagy has emerged as an...
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Antiplasmodial natural products: an update
BackgroundMalaria remains a significant public health challenge in regions of the world where it is endemic. An unprecedented decline in malaria...
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Are peptides a solution for the treatment of hyperactivated JAK3 pathways?
While the inactivation mutations that eliminate JAK3 function lead to the immunological disorders such as severe combined immunodeficiency,...
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In vitro cytotoxic and antioxidant activities of Pikut Trichinthalamaga remedy
The Pikut Trichinthalamaga remedy appears in ancient Thai pharmacy scripture, as a purgative, and includes Rhubarb ( Rheum palmatum L.), Myrabulan...
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Gambogic acid enhances the radiosensitivity of human esophageal cancer cells by inducing reactive oxygen species via targeting Akt/mTOR pathway
Radiotherapy is a widespread treatment in human solid tumors. However, therapy resistance and poor prognosis are still problems. Gambogic acid (GA),...
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Suppression of Primary Splenocyte Proliferation by Artemisia capillaris and Its Components
The host immune system is the first line of host defense, consisting mainly of innate and adaptive immunity. Immunity must be maintained,...
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Protection of plasma transfusion against lipopolysaccharide/d-galactosamine-induced fulminant hepatic failure through inhibiting apoptosis of hepatic cells in mice
Fulminant hepatic failure is a severe clinical condition associated with extremely poor outcomes and high mortality. A number of studies have...