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Phase 1 study of MRX34, a liposomal miR-34a mimic, in patients with advanced solid tumours
BackgroundIn this first-in-human, Phase 1 study of a microRNA-based cancer therapy, the recommended Phase 2 dose (RP2D) of MRX34, a liposomal mimic...
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The epigenomics of sarcoma
Epigenetic regulation is critical to physiological control of development, cell fate, cell proliferation, genomic integrity and, fundamentally,...
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Soft Tissue Sarcomas
Soft tissue sarcomas (STS) are a heterogeneous group of malignant tumors of mesenchymal origin, accounting for less than 1% of all adult malignancies...
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NTRK-Targeted Therapy in Lung Cancer
Gene rearrangements or fusions as a tumorigenic genomic driver event have been identified as a common recurrent occurrence in a variety of human...
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Receptors for Targeting Gastrointestinal Tract Cancer
Cancers of the gastrointestinal tract (GIT)Gastrointestinal tract (GIT) GIT Gastrointestinal tract (GIT) are among the most prevalent and fatal...
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Computational analysis of receptor tyrosine kinase inhibitors and cancer metabolism: implications for treatment and discovery of potential therapeutic signatures
BackgroundReceptor tyrosine kinase (RTK) inhibitors are frequently used to treat cancers and the results have been mixed, some of these small...
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Resistance to Inhibitors of Angiogenesis
Angiogenesis, a process that is predominantly driven by the vascular endothelial growth factor (VEGF) signaling pathway, plays an essential role in...
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Dovitinib in patients with gastrointestinal stromal tumour refractory and/or intolerant to imatinib
Background:This multicentre phase II trial (DOVIGIST) evaluated the antitumour activity of dovitinib as second-line treatment of patients with...
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Types of Cancer
Cancer is an extremely fatal disease, not only in developed but also in develo** countries as it affects six million lives each year worldwide....
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Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond
l -Tryptophan (Trp) metabolism through the kynurenine pathway (KP) is involved in the regulation of immunity, neuronal function and intestinal...
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Advances in studies of tyrosine kinase inhibitors and their acquired resistance
Protein tyrosine kinase (PTK) is one of the major signaling enzymes in the process of cell signal transduction, which catalyzes the transfer of...
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Mechanisms of Anti-angiogenic Therapy
Angiogenesis inhibition is a promising approach to fight cancer. This strategy offers some advantages in comparison with conventional drugs, such as...
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Cancer Therapy
This chapter comprehensively and systematically reviews the different modalities of anti-cancer therapies. Therapeutic options are classified into...
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A selective c-Met and Trks inhibitor Indo5 suppresses hepatocellular carcinoma growth
BackgroundHuman hepatocellular carcinoma (HCC) lacks effective curative therapy and there is an urgent need to develop a novel molecular-targeted...
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Ilixadencel – an Allogeneic Cell-Based Anticancer Immune Primer for Intratumoral Administration
Intratumoral administration of an immune primer is a therapeutic vaccine strategy aimed to trigger dendritic cell (DC)-mediated cross-presentation of...
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A history of exploring cancer in context
The concept that progression of cancer is regulated by interactions of cancer cells with their microenvironment was postulated by Stephen Paget over...
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Care of adults with neurofibromatosis type 1: a clinical practice resource of the American College of Medical Genetics and Genomics (ACMG)
DisclaimerThis practice resource is designed primarily as an educational resource for medical geneticists and other clinicians to help them provide...