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Role of adolescent-formed, context-drug-associations on reinstatement of drug-seeking behavior in rats
RationaleDrug use during adolescence results in a lifelong risk to develop substance-use disorders. Adolescent rats are less reactive to...
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Effects of Prenatal and Early Postnatal Administration of Valproate on Behavior and Cyhtological Characteristics in Wistar Rats
Prenatal administration of valproic acid (VA) and its salts is a common approach to modeling impairments to nervous system development; the sequelae...
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Mice learn multi-step routes by memorizing subgoal locations
The behavioral strategies that mammals use to learn multi-step routes are unknown. In this study, we investigated how mice navigate to shelter in...
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Opioid withdrawal: role in addiction and neural mechanisms
Withdrawal from opioids involves a negative affective state that promotes maintenance of drug-seeking behavior and relapse. As such, understanding...
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Alternative Approaches to Understanding Habit Learning in the Dorsolateral Striatum
Our daily lives are full of habits. Yet, even though we know them intimately, habits are surprisingly hard to pin down in laboratory settings in... -
Characterization of basal forebrain glutamate neurons suggests a role in control of arousal and avoidance behavior
The basal forebrain (BF) is involved in arousal, attention, and reward processing but the role of individual BF neuronal subtypes is still being...
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Outcome Devaluation as a Means of Distinguishing Habits from Goal-Directed Actions
The outcome devaluation task is a powerful method of distinguishing between goal-directed and habitual behavior by modifying the value of the... -
Sex differences in mouse infralimbic cortex projections to the nucleus accumbens shell
BackgroundThe nucleus accumbens (NAc) is an important region in motivation and reward. Glutamatergic inputs from the infralimbic cortex (ILC) to the...
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Impact of a History of Caloric Restriction and a Frustration Stress Manipulation on Binge-Like Eating Behavior in Female Rats: Preclinical Results
Medications, at present, play a limited role on eating disorders. Currently, only two drugs were approved by the Food and Drug Administration,... -
Role of Endogenous Opioids in the Pathophysiology of Obesity and Eating Disorders
This second chapter in our trilogy reviews and critically appraises the scientific evidence for the role of endogenous opioid system (EOS) activity... -
Neurocircuitry of Predatory Hunting
Predatory hunting is an important type of innate behavior evolutionarily conserved across the animal kingdom. It is typically composed of a set of...
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Characteristics of the Neuronal Support for Operative Behavior Formed by Mono- and Multistep Methods
We report here studies to determine whether, and if so, how, the neuronal support for behavior depends on the number of training steps presented in...
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Role of the GABAa and GABAb receptors of the central nucleus of the amygdala in compulsive cocaine-seeking behavior in male rats
RationaleCompulsive cocaine use, defined as the continued use despite the dire consequences, is a hallmark of cocaine addiction. Thus, understanding...
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Models of Autism and Methods for Assessing Autistic-Like Behavior in Animals
Autistic spectrum disorders (ASD), including autism, constitute a wide range of states and are associated with deficit to social communications,...
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Assessment of Binge-Like Eating Behavior in Mice Utilizing a Weekly Intermittent Access Paradigm
In humans, binge eating (BE) is central to the harmful effects of bulimia and binge eating disorder (BED). An estimated 30% of the obese population... -
The impact of three weeks of pre-quit varenicline on reinforcing value and craving for cigarettes in a laboratory choice procedure
RationaleVarenicline, a partial nicotinic agonist, is theorized to attenuate pre-quit smoking reinforcement and post-quit withdrawal and craving....
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The effects of virtual reality environmental enrichments on craving to food in healthy volunteers
RationaleEnvironmental enrichment (EE) is a non-pharmacological approach that has been shown to be effective in reducing food-taking in rats. Studies...
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Sex-dependent divergence in the effects of GLP-1 agonist exendin-4 on alcohol reinforcement and reinstatement in C57BL/6J mice
RationaleAlcohol use disorder remains a leading cause of preventable deaths, and current treatments have limited efficacy. Glucagon-like peptide 1...
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Effects of Single-Session Normobaric Hypoxia in Rats Aged 10 Days on Sensorimotor Development and Behavior
Fetal or neonatal hypoxia is one of the main causes of neonatal mortality and results in long-term impairments to motor and cognitive functions. The...
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Integrative Functions of the Cortico-Strio-Thalamo-Cortical System of the Brain
This article discusses the neurophysiological mechanisms underlying the spatiotemporal integration of different brain structures and the...