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Physiological Functions of the Liver
The liver has a strategically important position in the circulation. It is the first organ that comes in contact with the blood after its exposure to... -
Subcellular Biochemical and Pathological Correlates in Experimental Models of Hepatotoxicity
Side effects of drugs often result from impairment of liver function or structural damage to hepatocytes. To evaluate toxic interactions, the... -
Hepatotoxicity of Cardiovascular Drugs
Society often pays a price for the progress achieved in the therapeutic benefits offered by new drugs, namely, an increased incidence of toxic side... -
Localization of Alagille syndrome to 20p11.2-p12 by linkage analysis of a three-generation family
Alagille syndrome (AGS) or arteriohepatic dysplasia is a rare but well-defined clinical entity that is usually inherited as an autosomal dominant...
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Stem Cell Activation in the Acetylaminofluorene-Treated Regenerating Rat Liver: A Bile Ductular Reaction?
The ability of the liver to regenerate in response to the loss of hepatocytes is widely recognised, and this is usually accomplished by the... -
The immunosuppressant FK506 inhibits the damage to mouse pancreatic islets induced by low dose streptozocin
Diabetes mellitus was induced in 40 male C57BL6 mice by injection of a low dose of streptozocin (45 mg/kg body weight) on 5 consecutive days. Twenty...
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The Uridine Diphosphate Glucuronosyltransferase Multigene Family: Function and Regulation
Glucuronidation is a major detoxication pathway in all vertebrates examined, from the most primitive (fish; Clarke et al. 1991) to the most evolved... -
Roles of Uridine Diphosphate Glucuronosyltransferases in Chemical Carcinogenesis
Roles of isozymes of the uridine diphosphate (UDP)-glueuronosyltransferase (UGT) family (EC 2.4.1.17) will be discussed in the light of recent... -
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Chromosomal localization of seven PAX genes and cloning of a novel family member, PAX-9
In the human paired box-containing ( PAX ) gene family, only two members, PAX-3 and PAX-6 , which are associated with Waardenburg's syndrome and...
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Significance of the peri-insular extracellular matrix for islet isolation from the pancreas of rat, dog, pig, and man
The presence and distribution in the peri-insular region of extracellular matrix, and in particular basement membrane, was investigated in a...
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Differential expression of translation-associated genes in benign and malignant human breast tumours
The human gene sequences encoding the translation-associated functions of alpha-subunit of elongation factor 1 (EF-1 alpha) and the ubiquitin...
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Natural Toxicants in Foods
The purpose of exploring the potential naturally occurring toxic hazards of food plants is not to suggest an irrational avoidance of these common... -
Synaptophysin immunoreactivity in the mammalian endocrine pancreas
Synaptophysin, a major membrane glycoprotein of small presynaptic vesicles in neurons, has also been found in microvesicles of endocrine cells, e.g.,...
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Cellular and Molecular Mechanisms of Hepatocarcinogenesis Associated with Hepadnavirus Infection
A large number of inorganic and organic chemicals act as carcinogens in the liver. Most of these are not active until they are metabolized into... -
The antigen of bile canaliculi of the mouse hepatocyte: identification and ultrastructural localization
The AgB10 antigen of bile canaliculi of the mouse hepatocyte was identified using monoclonal antibodies. The M r value of 116000 for AgB10 was...
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N-Nitroso Compounds
The N-nitroso compounds fall into the category of carcinogens discovered through proposed industrial use (Barnes 1974). In the early 1950s the then... -
Immunocytochemical evidence of phospholipase A2 in pancreatic tumors — Diagnostic values
Phospholipase A 2 is an enzyme which is produced in acinar cells, and persists even in regressive states of chronic pancreatitis, when the production...