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Is radical radiotherapy with/without surgery an effective treatment in the lymphoepithelial carcinoma of the salivary gland？
BackgroundThere is limited information of radical radiotherapy (RT) on lymphoepithelial carcinoma of salivary gland (LECSG) regarding to the rarity...
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Dosimetric quality of HyperArc in boost radiotherapy for single glioblastoma: comparison with CyberKnife and manual VMAT
BackgroundStereotactic radiotherapy (SRT) and hypo-fractionated radiotherapy are feasible treatment options for single glioblastoma multiforme when...
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Role of postoperative radiotherapy in resected adenoid cystic carcinoma of the head and neck
PurposeAlthough postoperative radiotherapy (PORT) is demonstrably effective in local control of head and neck adenoid cystic carcinoma (HNACC), its...
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High-dose stereotactic radiotherapy boost in the treatment of squamous cell carcinoma of the head and neck region
BackgroundSurgical resection with adjuvant concurrent radiochemotherapy is the standard of care for stage III–IV oral cavity cancer. In some cases,...
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Development of a risk prediction model for radiation dermatitis following proton radiotherapy in head and neck cancer using ensemble machine learning
PurposeThis study aims to develop an ensemble machine learning-based (EML-based) risk prediction model for radiation dermatitis (RD) in patients with...
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Impact of a mobile application (reminder app) on acute toxicity during radiotherapy of head-and-neck cancer – results of a randomized phase III trial (RAREST-02)
BackgroundRadiotherapy of head-and-neck cancer (SCCHN) is often associated with acute toxicity. In a previous trial, daily reminders by staff members...
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Cetuximab and anemia prevention in head and neck cancer patients undergoing radiotherapy
BackgroundEpidermal growth factor receptor (EGFR) activation is associated with increased production of interleukin 6 (IL6), which is intensified by...
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Patient-related risk factors for late rectal bleeding after hypofractionated radiotherapy for localized prostate cancer: a single-center retrospective study
BackgroundSeveral studies have reported patient-related risk factors for late rectal bleeding following conventionally fractionated radiotherapy for...
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Postoperative radiotherapy for supraglottic cancer on real-world data: can we reduce dose to lymph node levels?
PurposeTo evaluate prognosis for reducing postoperative radiotherapy (PORT) dose to lymph node levels of supraglottic cancer (SC) on real-world data.
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THeragnostic utilities for neoplastic DisEases of the rectum by MRI guided radiotherapy (THUNDER 2) phase II trial: interim safety analysis
BackgroundThe THUNDER-2 phase II single institutional trial investigates the benefits of MRI-guided radiotherapy (MRIgRT) in treating locally...
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Comparison of outcomes between early-stage cervical cancer patients without high-risk factors undergoing adjuvant concurrent chemoradiotherapy and radiotherapy alone after radical surgery
PurposeFor patients with early-stage cervical cancer without high-risk factors, there is no consensus regarding the optimal postoperative treatment...
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Hospitalization and definitive radiotherapy in lung cancer: incidence, risk factors and survival impact
BackgroundUnplanned hospitalization during cancer treatment is costly, can disrupt treatment, and affect patient quality of life. However, incidence...
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Outcomes of surgical resection and intraoperative electron radiotherapy for patients with para-aortic recurrences of gastrointestinal and gynecologic malignancies
BackgroundPara-aortic lymph node (PALN) metastases from primary pelvic malignancies are often treated with resection, but recurrence is common. We...
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Preoperative hypofractionated radiotherapy for soft tissue sarcomas: a systematic review
BackgroundSoft tissue sarcomas (STS) represent a diverse group of rare malignant tumors. Currently, five to six weeks of preoperative radiotherapy...
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Radical prostatectomy versus external beam radiotherapy with androgen deprivation therapy for high-risk prostate cancer: a systematic review
BackgroundTo summarize recent evidence in terms of health-related quality of life (HRQoL), functional and oncological outcomes following radical...
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Health-related quality of life and patient-reported symptoms after postoperative proton beam radiotherapy of cervical and endometrial cancer: 2-year results of the prospective phase II APROVE-trial
IntroductionThe APROVE-trial investigated the tolerability of postoperative proton beam therapy in women with cervical or endometrial cancer. The...
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Real-world outcomes of PD-L1 inhibitors combined with thoracic radiotherapy in the first-line treatment of extensive stage small cell lung cancer
BackgroundThe CREST study showed that the addition of thoracic radiotherapy (TRT) could improve the survival rate in patients with extensive stage...
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CT radiomics features of meso-esophageal fat in predicting overall survival of patients with locally advanced esophageal squamous cell carcinoma treated by definitive chemoradiotherapy
ObjectiveTo investigate the value of CT radiomics features of meso-esophageal fat in the overall survival (OS) prediction of patients with locally...
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Variability of α/β ratios for prostate cancer with the fractionation schedule: caution against using the linear-quadratic model for hypofractionated radiotherapy
BackgroundProstate cancer (PCa) is known to be suitable for hypofractionated radiotherapy due to the very low α/β ratio (about 1.5–3 Gy). However,...