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Association Between Diverse Cell Death Patterns Related Gene Signature and Prognosis, Drug Sensitivity, and Immune Microenvironment in Glioblastoma
Glioblastoma (GBM) is the most invasive type of glioma and is difficult to treat. Diverse programmed cell death (PCD) patterns have a significant...
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Honokiol induces apoptosis-like death in Cryptocaryon irritans Tomont
BackgroundCryptocaryon irritans , a common parasite in tropical and subtropical marine teleost fish, has caused serious harm to the marine...
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Stimulators of immunogenic cell death for cancer therapy: focusing on natural compounds
A growing body of evidence indicates that the anticancer effect of the immune system can be activated by the immunogenic modulation of dying cancer...
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Analysis of clinical characteristics and risk factors for death due to severe influenza in children
ObjectiveThe study analyzed the clinical features of children who had severe influenza and discussed on the risk factors associated with death in...
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Attenuated Dengue virus PV001-DV induces oncolytic tumor cell death and potent immune responses
BackgroundViral therapies developed for cancer treatment have classically prioritized direct oncolytic effects over their immune activating...
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Sympathetic-Mediated Intestinal Cell Death Contributes to Gut Barrier Impairment After Stroke
Tissue injury induced by stroke is traditionally thought to be localised to the brain. However, there is an accumulating body of evidence to...
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Molecular mechanisms of cell death in bronchopulmonary dysplasia
Bronchopulmonary dysplasia (BPD) in neonates is the most common pulmonary disease that causes neonatal mortality, has complex pathogenesis, and lacks...
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Inflammasome Activation Mediates Apoptotic and Pyroptotic Death in Astrocytes Under Ischemic Conditions
Inflammation is a hallmark mechanism of ischemic stroke-induced brain injury. Recent studies have shown that an intracellular multimeric protein...
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Targeting hyaluronan-mediated motility receptor (HMMR) enhances response to androgen receptor signalling inhibitors in prostate cancer
BackgroundResistance to androgen receptor signalling inhibitors (ARSIs) represents a major clinical challenge in prostate cancer. We previously...
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Ochratoxin A induces hepatic and renal toxicity in mice through increased oxidative stress, mitochondrial damage, and multiple cell death mechanisms
Ochratoxin A (OTA) is a widespread food toxin produced by Aspergillus ochraceus and other molds. In this study, we developed and established acute...
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Body mass index, triglyceride-glucose index, and prostate cancer death: a mediation analysis in eight European cohorts
BackgroundInsulin resistance is a hypothesised biological mechanism linking obesity with prostate cancer (PCa) death. Data in support of this...
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Expression and Purification of Mammalian NMDA Receptor Protein for Functional Characterization
N-methyl-D-aspartate (NMDA) receptors are critical for brain function and serve as drug targets for the treatment of neurological and psychiatric...
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Chondrocyte death involvement in osteoarthritis
Chondrocyte apoptosis is known to contribute to articular cartilage damage in osteoarthritis and is correlated to a number of cartilage disorders....
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The NMDA Receptor System and Developmental Neurotoxicity
The NMDA receptor system has been implicated in the etiology of ketamine-induced developmental neurotoxicity. Prolonged ketamine exposure resulting...
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Liver receptor homolog-1: structures, related diseases, and drug discovery
Liver receptor homolog-1 (LRH-1), a member of the nuclear receptor superfamily, is a ligand-regulated transcription factor that plays crucial roles...
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Capsaicin, The Vanilloid Receptor TRPV1 Agonist in Neuroprotection: Mechanisms Involved and Significance
Hot peppers, also called chilli, chilli pepper, or paprika of the plant genus Capsicum (family Solanaceae ), are one of the most used vegetables and...
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Toll-Like Receptor 4 Signaling in Neurons Mediates Cerebral Ischemia/Reperfusion Injury
In microglia, Toll-like receptor 4 (TLR4) is well known to contribute to neuroinflammatory responses following brain ischemia. TLR4 is also expressed...
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Death-associated protein kinase 1 as a therapeutic target for Alzheimer's disease
Alzheimer’s disease (AD) is the most prevalent form of dementia in the elderly and represents a major clinical challenge in the ageing society....
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Ferroptosis in tumors and its relationship to other programmed cell death: role of non-coding RNAs
Programmed cell death (PCD) plays an important role in many aspects of individual development, maintenance of body homeostasis and pathological...
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Chaperone- and PTM-mediated activation of IRF1 tames radiation-induced cell death and the inflammatory response
The key role of structural cells in immune modulation has been revealed with the advent of single-cell multiomics, but the underlying mechanism...
