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1. Preclinical Development of a Novel Epitope-based DNA Vaccine Candidate against SARS-CoV-2 and Evaluation of Immunogenicity in BALB/c Mice

   The protective efficacies of current licensed vaccines against COVID-19 have significantly reduced as a result of SARS-CoV-2 variants of...

   Kanwal Khalid, Hui Xuan Lim, ... Chit Laa Poh in AAPS PharmSciTech

   Article 12 March 2024
   

2. Random-PE: an efficient integration of random sequences into mammalian genome by prime editing

   Prime editing (PE) enables efficiently targeted introduction of multiple types of small-sized genetic change without requiring double-strand breaks...

   Yaoge Jiao, Lifang Zhou, ... Shaohua Yao in Molecular Biomedicine

   Article Open access 18 November 2021
   

3. Methods and applications of genome-wide profiling of DNA damage and rare mutations

   DNA damage is a threat to genome integrity and can be a cause of many human diseases, owing to either changes in the chemical structure of DNA or...

   Gerd P. Pfeifer, Seung-Gi ** in Nature Reviews Genetics

   Article 25 June 2024
   

4. DNA: The Master Molecule

   All living creatures have DNA (deoxyribonucleic acid) as their blueprint for life. This DNA primarily exists in the famous double helix and is...

   Amit Kumar, Amita Kashyap, Edwin Huffine in Handbook of DNA Forensic Applications and Interpretation

   Chapter 2022
   

5. Enrichment, Sequencing, and Identification of DNA Bacteriophages from Fecal Samples

   Research on individual viruses and phages, as well as viral populations (viromes), is greatly expanding. Phages and viromes are increasingly...

   Quentin Lamy-Besnier, Julian R. Garneau in Viral Metagenomics

   Protocol 2024
   

6. Imaging extrachromosomal DNA (ecDNA) in cancer

   Extrachromosomal DNA (ecDNA) are circular regions of DNA that are found in many cancers. They are an important means of oncogene amplification, and...

   Karin Purshouse, Steven M. Pollard, Wendy A. Bickmore in Histochemistry and Cell Biology

   Article Open access 16 April 2024
   

7. Evaluation of human papillomavirus DNA in colorectal cancer and adjacent mucosal tissue samples

   Background

   Although the role of viral agents, such as human papillomavirus (e.g. HPV16, HPV18) in colorectal cancer (CRC) has been previously...

   Luisa Galati, Purnima Gupta, ... Tarik Gheit in Infectious Agents and Cancer

   Article Open access 08 November 2023

8. No detectable truncating mutations in large T antigen (LT-Ag) sequence of Merkel cell polyomavirus (MCPyV) DNA obtained from porocarcinomas

   Merkel cell polyomavirus (MCPyV) is associated with Merkel cell carcinoma (MCC). In tumor cells the MCPyV large T antigen (LT-Ag) is frequently found...

   Rosaria Arvia, Mauro Sollai, ... Krystyna Zakrzewska in Infectious Agents and Cancer

   Article Open access 21 March 2024
   

9. Crosstalk between RNA m⁶A and DNA methylation regulates transposable element chromatin activation and cell fate in human pluripotent stem cells

   Transposable elements (TEs) are parasitic DNA sequences accounting for over half of the human genome. Tight control of the repression and activation...

   Tongyu Sun, Yueyuan Xu, ... Yarui Diao in Nature Genetics

   Article 20 July 2023
   

10. H3K9me3 asymmetry: epigenetic choreography in DNA replication for genomic stability

    Parental histones, which are modified distinctively from their newly synthesized counterparts, are recycled during DNA replication for the...

    Wei-Guo Zhu in Genome Instability & Disease

    Article 28 November 2023
    

11. DNA Methylation and Epigenetic Aging Biomarkers in Huntington’s Disease

    DNA methylation is an epigenetic modification that plays critical roles in several important processes, including regulation of transcription,...

    Elizabeth A. Thomas in Biomarkers for Huntington's Disease

    Chapter 2023
    

12. Single-Molecule Imaging of Enzymatic Reactions on DNA Origami

    The interaction between enzymes is very important for understanding of enzyme functions and shed light on enzymatic reaction mechanisms. With the...

    An Yan, Lele Sun, Di Li in DNA and RNA Origami

    Protocol 2023
    

13. Rabbit targeted genomic sequences after heterologous hybridization using human exome

    Objective

    Causal mutations for major genes that underlie a broad range of morphological traits are often located within exons of genes that then...

    Nathalie Iannuccelli, Julien Sarry, ... Julie Demars in BMC Research Notes

    Article Open access 19 August 2022

14. Repetitive Sequences, Codon Usage Bias and Phylogenetic Analysis of the Plastome of Miliusa glochidioides

    Annonaceae is the largest family in Magnoliales, exhibiting the greatest diversity among and within genera. In this study, we conducted an analysis...

    Yangying Gan, **gyao **, ... Caixia Peng in Biochemical Genetics

    Article 02 July 2024
    

15. Variant calling and benchmarking in an era of complete human genome sequences

    Genetic variant calling from DNA sequencing has enabled understanding of germline variation in hundreds of thousands of humans. Sequencing...

    Nathan D. Olson, Justin Wagner, ... Justin M. Zook in Nature Reviews Genetics

    Article 14 April 2023
    

16. DNA Methylation is Involved in Sex Determination in Spinach

    DNA methylation plays a critical role in the modulation of gene expression. The role of DNA methylation in sex determination was investigated in...

    Keli Jia, Jiaming Duan, ... Miao Hu in Biochemical Genetics

    Article 11 November 2023
    

17. DNA origami: a tool to evaluate and harness transcription factors

    Alongside other players, such as CpG methylation and the “histone code,” transcription factors (TFs) represent a key feature of gene regulation. TFs...

    Alexios-Fotios A. Mentis, Kostas A. Papavassiliou, Athanasios G. Papavassiliou in Journal of Molecular Medicine

    Article 09 October 2023
    

18. Rapid profiling of Plasmodium parasites from genome sequences to assist malaria control

    Background

    Malaria continues to be a major threat to global public health. Whole genome sequencing (WGS) of the underlying Plasmodium parasites has...

    Jody E. Phelan, Anna Turkiewicz, ... Taane G. Clark in Genome Medicine

    Article Open access 10 November 2023
    

19. DNA Methylation in Experimental Ischemic Brain Injury

    The enrichment of angioneurology with fundamental achievements is leading to an understanding of new important aspects of the pathogenesis of...

    N. S. Shcherbak, I. O. Suchkova, ... I. A. Voznyuk in Neuroscience and Behavioral Physiology

    Article 01 May 2023

20. Prioritizing genomic variants pathogenicity via DNA, RNA, and protein-level features based on extreme gradient boosting

    Genetic diseases are mostly implicated with genetic variants, including missense, synonymous, non-sense, and copy number variants. These different...

    Maolin Ding, Ken Chen, ... Huiying Zhao in Human Genetics

    Article 04 April 2024