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Assembly of platforms for signal transduction in the new era: dimerization, helical filament assembly, and beyond
Supramolecular organizing center (SMOC)-mediated signal transduction is an emerging concept in the field of signal transduction that is ushering in a...
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Anti-apoptosis effect of traditional Chinese medicine in the treatment of cerebral ischemia–reperfusion injury
Cerebral ischemia, one of the leading causes of neurological dysfunction of brain cells, muscle dysfunction, and death, brings great harm and...
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Reactive gliosis in Alzheimer’s disease: a crucial role for cognitive impairment and memory loss
Alzheimer’s disease (AD) is a neurodegenerative disorder that leads to cognitive decline and memory loss. Insulin resistance in central nervous...
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TLR7 Agonists Modulate the Activation of Human Conjunctival Epithelial Cells Induced by IL-1β via the ERK1/2 Signaling Pathway
Conjunctival epithelia cells play an important role in the development of allergic reactions. TLR7 agonists have been shown in studies to increase...
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E. coli LPS/TLR4/NF-κB Signaling Pathway Regulates Th17/Treg Balance Mediating Inflammatory Responses in Oral Lichen Planus
Oral lichen planus (OLP) is a chronic inflammatory autoimmune disease mediated by T cells. The imbalance of microflora has potential impacts on the...
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The Protective Effects of VVN001 on LPS-Induced Inflammatory Responses in Human RPE Cells and in a Mouse Model of EIU
To investigate protective effects of VVN001 on lipopolysaccharide (LPS)-induced inflammatory response in human retinal pigment epithelial (RPE) cells...
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Comparison of the Adaptive Capacity in Old and Young Wistar Rats to Stress Exposure and Acute Hypoxic Hypoxia
We compared behavioral and psychoemotional manifestations of young and old male Wistar rats in elevated plus-maze, the levels of corticosterone and...
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N6-Methyladenosine Methylation of mRNA in Cell Apoptosis
Apoptosis, a highly controlled homeostatic mechanism that eliminates single cells without destroying tissue function, occurs during growing...
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Regulatory T Cells in SLE
Autoimmune diseases such as type 1 diabetes and systemic lupus erythematosus are chronic inflammatory diseases caused by immune system dysfunction....
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3D and 4D Printing in Digital Healthcare
Three-dimensional (3D) printing is a digital manufacturing system that is transforming pharmaceutical production by empowering patients to play an...
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Fabrication of Carboxymethylcellulose-Gelatin Dissolving Microneedle Patch for Pain-Free, Efficient, and Controlled Transdermal Delivery of Insulin
PurposeDissolving microneedle patches are attracting attention as they are associated with improved patient compliance and safety.
Methods ...
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Personalized Tuberculosis Care for Drug-Resistant Tuberculosis
Drug-resistant tuberculosisTuberculosisdrug-resistant (DR-TB) includes mono-resistant forms of TB and multidrug-resistant tuberculosis (MDR-TB),...
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Elucidating the Role of miRNA in Inflammasome-Mediated Immune Response in Leishmaniasis
The inflammasome is a cell cytoplasm-localized multimeric protein complex of host defense mechanism which gets activated due to infection in the...
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Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes
Neuroinflammation is associated with neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis....
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Multiscale reverse engineering of the human ocular surface
Here we present a miniaturized analog of a blinking human eye to reverse engineer the complexity of the interface between the ocular system and the...
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3D Printing of Microbial Polysaccharides
From the last three decades, innovative 3D printing processes have been progressively more investigated for food and regenerative medicine topics due...
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Role of Reactive Astrocytes in Alzheimer’s Disease
Astrocytes respond to any pathological stimulus to the central nervous system including in Alzheimer’s disease (AD). They undergo dramatic remodeling...
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Pharmacokinetics of a New Analgesic on the Basis of Hexaazaisowurtzitane Derivative
We studied pharmacokinetics of a new analgesic based on a hexaazaisowurtzitane derivative (thiowurtzine, TWZ). A method for measuring TWZ in organs...