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A novel colorectal cancer test combining microsatellite instability and BRAF/RAS analysis: Clinical validation and impact on Lynch syndrome screening
BackgroundLynch syndrome (LS) is under-diagnosed. UK National Institute for Health and Care Excellence guidelines recommend multistep molecular...
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Highly Sensitive Detection of PIK3CA Mutations by Loo**-Out Probes-Based Melting Curve Analysis
PIK3CA mutations have important therapeutic and prognostic implications in various cancer types. However, highly sensitive detection of PIK3CA ...
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Cost-effectiveness of latent tuberculosis infection testing and treatment with 6-week regimen among key population in rural communities in China: a decision analysis study
PurposeSeveral model studies suggested the implementation of latent tuberculosis infection (LTBI) testing and treatment could greatly reduce the...
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Clinical and financial impacts of abnormal liver biochemistry after liver transplantation
ObjectiveAfter liver transplant (LT) , many investigations are needed to evaluate abnormal liver function test (LFT), which has poor specificity for...
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Cluster analysis of cancer knowledge, attitudes and behaviors in the Moroccan population
BackgroundCancer has become a major health concern due to the increasing morbidity and mortality rates, and its negative social, economic...
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A Bibliometric Analysis of the Spatial Transcriptomics Literature from 2006 to 2023
In recent years, spatial transcriptomics (ST) research has become a popular field of study and has shown great potential in medicine. However, there...
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Impact of Introducing Infliximab Biosimilars on Total Infliximab Consumption and Originator Infliximab Prices in Eight Regions: An Interrupted Time-Series Analysis
ObjectiveWe aimed to assess whether the introduction of the first infliximab biosimilar was associated with changes in overall infliximab consumption...
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Rapid genomic sequencing for genetic disease diagnosis and therapy in intensive care units: a review
Single locus (Mendelian) diseases are a leading cause of childhood hospitalization, intensive care unit (ICU) admission, mortality, and healthcare...
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A Cost-Effectiveness Analysis of Biomarkers for Risk Prediction in Atrial Fibrillation
RationaleAtrial fibrillation (AF) is associated with an increased risk of thromboembolism. This risk is currently assessed with scoring systems based...
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Role of antiangiogenic agents in first-line treatment for advanced NSCLC in the era of immunotherapy
Background & objective“Anti-angiogenetic drugs plus chemotherapy” (anti-angio-chemo) and “immune checkpoint inhibitors plus chemotherapy” (ICI-chemo)...
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Proteomic analysis predicts anti-angiogenic resistance in recurred glioblastoma
BackgroundRecurrence is common in glioblastoma multiforme (GBM) because of the infiltrative, residual cells in the tumor margin. Standard therapy for...
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Factors Associated with Biosimilar Exclusions and Step Therapy Restrictions Among US Commercial Health Plans
BackgroundBiosimilars have been introduced with the goal of competing with high-priced biologic therapies, yet their adoption has been slower than...
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Consensus Head Acceleration Measurement Practices (CHAMP): Study Design and Statistical Analysis
Head impact measurement devices enable opportunities to collect impact data directly from humans to study topics like concussion biomechanics, head...
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Continuing the sequence? Towards an economic evaluation of whole genome sequencing for the diagnosis of rare diseases in Scotland
Novel developments in genomic medicine may reduce the length of the diagnostic odyssey for patients with rare diseases. Health providers must thus...
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The prognostic role of tumor mutation burden on survival of breast cancer: a systematic review and meta-analysis
BackgroundAs a potential genetic biomarker, tumor mutation burden (TMB) has made progress in numerous tumors. There are limited data regarding TMB...
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Isopropyl alcohol inhalation versus 5-HT3 antagonists for treatment of nausea: a meta-analysis of randomised controlled trials
PurposeNausea is a common and unpleasant sensation for which current therapies such as serotonin (5-HT 3 ) antagonists are often ineffective, while...
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Immunotherapy Guided by Immunohistochemistry PD-L1 Testing for Patients with NSCLC: A Microsimulation Model-Based Effectiveness and Cost-Effectiveness Analysis
BackgroundOn the basis of immunohistochemistry PD-L1 testing results, patients with advanced non-small cell lung cancer (NSCLC) are treated...
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C-reactive protein point of care testing in the management of acute respiratory infections in the Vietnamese primary healthcare setting – a cost benefit analysis
AimWe assess the cost-benefit implications of C-reactive protein (CRP) testing in reducing antibiotic prescription for acute respiratory infection in...
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Critical analysis of the prescription and evaluation of protein kinase inhibitors for oncology in Germany
The prices of oncology drugs have been rising progressively in recent years. Despite accounting for only a small share of prescriptions, oncology...
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Hit it hard: qualitative patient perspectives on the optimisation of immune checkpoint inhibition
BackgroundImmune checkpoint inhibitors have transformed the treatment landscape of many cancers, including melanoma and renal cell carcinoma (RCC)....
