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Clinical pilot study for EPID-based in vivo dosimetry using EPIgray™ for head and neck VMAT
This work details the clinical pilot study methodology used at Wellington Blood and Cancer Centre (WBCC) before the clinical release of in vivo...
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Tau and neuroinflammation in Alzheimer’s disease: interplay mechanisms and clinical translation
Alzheimer’s Disease (AD) contributes to most cases of dementia. Its prominent neuropathological features are the extracellular neuritic plaques and...
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Tolerance of clinical vancomycin-resistant Enterococcus faecium isolates against UV-C light from a mobile source
BackgroundAdmission to a room previously occupied by patients carrying environmentally robust pathogens implies an increased risk of acquiring those...
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LRRC superfamily expression in stromal cells predicts the clinical prognosis and platinum resistance of ovarian cancer
BackgroundLeucine-rich repeat sequence domains are known to mediate protein‒protein interactions. Recently, some studies showed that members of the...
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Micro-inflammation related gene signatures are associated with clinical features and immune status of fibromyalgia
BackgroundFibromyalgia (FM) is a multifaceted disease. Along with the genetic, environmental and neuro-hormonal factors, inflammation has been...
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Construction and verification of a novel circadian clock related long non-coding RNA model and prediction of treatment for survival prognosis in patients with hepatocellular carcinoma
Circadian clock genes are significant in the occurrence and development of HCC and long-non coding RNAs (lncRNAs) are closely related to HCC...
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Clinical Proteomics: Diagnostics and Prognostic Markers of Cancer
In the recent years, through the introduction of high-throughput technologies to innumerable fields of medicine, investigation of big cohorts of data...
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Anti-Amyloid Immunotherapies for Alzheimer’s Disease: A 2023 Clinical Update
The amyloid cascade hypothesis is a useful framework for therapeutic development in Alzheimer’s disease (AD). Amyloid b 1-42 (Aβ) has been the main...
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tRNA-derived fragments: mechanism of gene regulation and clinical application in lung cancer
Lung cancer, being the most widespread and lethal form of cancer globally, has a high incidence and mortality rate primarily attributed to challenges...
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Advancing Subcutaneous Dosing Regimens for Biotherapeutics: Clinical Strategies for Expedited Market Access
In recent years, subcutaneous administration of biotherapeutics has made significant progress. The self-administration market for rheumatoid...
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Analyzing molecular ty** and clinical application of immunogenic cell death-related genes in hepatocellular carcinoma
BackgroundHepatocellular carcinoma (HCC) is considered one of the most common cancers, characterized by low early detection and high mortality rates,...
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Lung cancer multi-omics digital human avatars for integrating precision medicine into clinical practice: the LANTERN study
BackgroundThe current management of lung cancer patients has reached a high level of complexity. Indeed, besides the traditional clinical variables...
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An analysis of clinical characteristics and prognosis of endometrioid ovarian cancer based on the SEER database and two centers in China
PurposeTo assess the clinical characteristics and the risk factors related to the unfavorable prognosis of endometrioid ovarian carcinoma (EOVC)...
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The potential mechanism of Bletilla striata in the treatment of ulcerative colitis determined through network pharmacology, molecular docking, and in vivo experimental verification
Ulcerative colitis (UC) is a chronic nonspecific intestinal inflammatory disease, which belongs to a subtype of inflammatory bowel disease, but still...
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Clinical significance of low expression of CADM3 in breast cancer and preliminary exploration of related mechanisms
BackgroundCell adhesion molecule 3 (CADM3), a transmembrane glycoprotein on cell membranes, plays a role in the way of ligand and receptor...
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Exploring the mechanism by which aqueous Gynura divaricata inhibits diabetic foot based on network pharmacology, molecular docking and experimental verification
BackgroundTo predict and validate the potential mechanism by which Gynura divaricata (GD) functions in the treatment of diabetic foot (DF).
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Assessment of the clinical and analytical performance of the Aptima SARS-CoV-2 assay using the VALCOR protocol
BackgroundThe COVID-19 pandemic highlighted the importance of diagnostic testing against curbing the spread of SARS-CoV-2. The urgent need and scale...
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Artificial intelligence: opportunities and challenges in the clinical applications of triple-negative breast cancer
Triple-negative breast cancer (TNBC) accounts for 15–20% of all invasive breast cancer subtypes. Owing to its clinical characteristics, such as the...
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Genetic spectrums and clinical profiles of critically ill neonates with congenital auricular deformity in the China Neonatal Genomes Project
Congenital auricular deformity (CAD) is a complex phenotype that may occur as a single malformation or part of a congenital syndrome. The genetic...
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Analysis of clinical characteristics and automatic monitoring of drug-induced arrhythmias in 167,546 inpatients
ObjectiveThe purpose of this study was to analyze the occurrence characteristics, clinical manifestations, medication distribution, and incidence of...
