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Perspectives on Biomaterial-Associated Infection: Pathogenesis and Current Clinical Demands
In this chapter, an overview of current medical implant devices and infection problems associated with implantation is provided, bridging the gap...
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Advance Class of Antibiotics of the Twenty-First Century
Microbes are the dominating organism on earth; they have impacted the life of animals as well as on humans during the course of evolution. Humans...
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Factors associated with bacteraemia due to multidrug-resistant organisms among bacteraemic patients with multidrug-resistant organism carriage: a case control study
BackgroundInfections caused by multidrug-resistant organisms (MDRO) are emerging worldwide. Physicians are increasingly faced with the question of...
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Bacteremia in Neutropenic Patients
Neutropenic patients are predisposed to polymicrobial infections that may cause substantial morbidity and mortality. NeutropeniaNeutropeniadefinition...
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Monomicrobial bone and joint infection due to Corynebacterium striatum: literature review and amoxicillin-rifampin combination as treatment perspective
Corynebacterium striatum is a ubiquitous colonizer of human skin and mucous membranes. It is increasingly involved in infections, especially with...
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Synthesis, molecular docking and ADME prediction of some new benzimidazole carboxamidines derivatives as antimicrobial agents
In this study, 15 new 1 H -benzimidazole-5-carboxamidine derivative compounds that could be new antimicrobial agents were synthesized and their...
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Antimicrobial Materials in Arthroplasty
With an increase in the number of total joint arthroplasty procedures being performed, the number of surgical site infections (SSI) and...
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DALBACEN cohort: dalbavancin as consolidation therapy in patients with endocarditis and/or bloodstream infection produced by gram-positive cocci
ObjectivesTo analyse the effectiveness of dalbavancin (DBV) in clinical practice as consolidation therapy in patients with bloodstream infection...
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Phenotypic and genotypic characterization of antibiotic resistance of methicillin-resistant Staphylococcus aureus isolated from hospital food
BackgroundPathogenic biotypes of the Methicillin-resistant Staphylococcus aureus (MRSA) strains are considered to be one of the major cause of...
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A study on combination of daptomycin with selected antimicrobial agents: in vitro synergistic effect of MIC value of 1 mg/L against MRSA strains
BackgroundDaptomycin is an important drug used in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infection. A high dose of...
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Clinical Pharmacokinetics and Pharmacodynamics of Delafloxacin
Delafloxacin has recently received approval by the US Food and Drug Administration for the treatment of acute bacterial skin and skin structure...
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Emerging and Difficult to Treat Nontuberculous Mycobacteria Infections
Nontuberculous mycobacteria [NTM] are a large group of environmental organisms [>150 species] that are distributed worldwide, but only a few are...
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The Role of Pharmacometrics in the Development of Antimicrobial Agents
We live in a world teeming with antimicrobial-resistant pathogens. For a number of pan-resistant pathogens, our once plentiful antimicrobial...
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Antimicrobial Stewardship in Immunocompromised Hosts
Although an antimicrobial stewardship program (ASP) as a primary tool to combat global development of antimicrobial resistanceAntimicrobial...
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The expanding role of prodrugs in contemporary drug design and development
Prodrugs are molecules with little or no pharmacological activity that are converted to the active parent drug in vivo by enzymatic or chemical...
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Impediments to Discovery of New Antimicrobials with New Modes of Action
During the golden age of antibiotic discovery (1945–1970), little thought was given to the possibility that someday we would run out of them. It is...
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Heteroresistance: A Harbinger of Future Resistance
During infection, bacterial populations often contain subpopulations that exhibit reduced antimicrobial susceptibility. The resulting population...
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Antibiotic resistance genes in the Actinobacteria phylum
The Actinobacteria phylum is one of the oldest bacterial phyla that have a significant role in medicine and biotechnology. There are a lot of genera...
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Laboratory Investigations and Result Interpretation
Proper clinical diagnosis, knowledge of the animal/s history, clinical experience as well as results of laboratory tests, support evidence-based, and...
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Continued in vitro cefazolin susceptibility in methicillin-susceptible Staphylococcus aureus
ObjectivesIn vitro trends of cefazolin and ceftriaxone susceptibilities from pediatric clinical isolates of methicillin-susceptible Staphylococcus...
